Detalhe da pesquisa
1.
Identification of potent and selective MTH1 inhibitors.
Bioorg Med Chem Lett
; 26(6): 1503-1507, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26898335
2.
Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem J
; 466(2): 337-46, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25486442
3.
Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 25(5): 1104-9, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25666823
4.
Structure guided design of a series of sphingosine kinase (SphK) inhibitors.
Bioorg Med Chem Lett
; 23(16): 4608-16, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23845219
5.
Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.
Bioorg Med Chem Lett
; 22(19): 6212-7, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22929232
6.
Mutational analysis of G-protein coupled receptor--FFA2.
Biochem Biophys Res Commun
; 405(1): 122-7, 2011 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21216233
7.
A novel series of IKKß inhibitors part II: description of a potent and pharmacologically active series of analogs.
Bioorg Med Chem Lett
; 21(1): 423-6, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21074992
8.
A novel series of IKKß inhibitors part I: Initial SAR studies of a HTS hit.
Bioorg Med Chem Lett
; 21(1): 417-22, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21074993
9.
The synthesis and SAR of novel diarylsulfone 11ß-HSD1 inhibitors.
Bioorg Med Chem Lett
; 20(23): 7071-5, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20971000
10.
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.
J Med Chem
; 63(21): 12957-12977, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33118821
11.
Thermodynamic analysis of mRNA cap binding by the human initiation factor eIF4E via free energy perturbations.
J Am Chem Soc
; 131(50): 18139-46, 2009 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19924990
12.
Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).
Bioorg Med Chem Lett
; 19(5): 1522-7, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19181519
13.
Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.
Nat Commun
; 10(1): 1402, 2019 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926793
14.
Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.
J Med Chem
; 62(22): 10258-10271, 2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31736296
15.
Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2.
Mol Pharmacol
; 74(6): 1599-609, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18818303
16.
Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.
Bioorg Med Chem Lett
; 18(24): 6352-6, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18993068
17.
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov
; 8(12): 1582-1597, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30254093
18.
Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
J Med Chem
; 49(10): 2898-908, 2006 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-16686533
19.
5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties.
ACS Med Chem Lett
; 7(7): 666-70, 2016 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437074
20.
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.
J Med Chem
; 59(1): 431-47, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26652588