Detalhe da pesquisa
1.
Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity.
Bioorg Med Chem Lett
; 95: 129487, 2023 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37734423
2.
Differential Inhibition of LRRK2 in Parkinson's Disease Patient Blood by a G2019S Selective LRRK2 Inhibitor.
Mov Disord
; 36(6): 1362-1371, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33836114
3.
Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.
J Biol Chem
; 290(8): 4908-4927, 2015 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25533468
4.
G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage.
NPJ Parkinsons Dis
; 10(1): 49, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38429321
5.
Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.
J Neurosci
; 31(45): 16194-207, 2011 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22072671
6.
The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment.
EMBO Rep
; 11(6): 473-8, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20467438
7.
Selective Inhibitors of G2019S-LRRK2 Kinase Activity.
J Med Chem
; 63(23): 14821-14839, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33197196
8.
SynGAP regulates steady-state and activity-dependent phosphorylation of cofilin.
J Neurosci
; 28(50): 13673-83, 2008 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19074040
9.
Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.
J Physiol
; 586(24): 5885-900, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18936077
10.
Spine architecture and synaptic plasticity.
Trends Neurosci
; 28(4): 182-7, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15808352
11.
Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases?
F1000Res
; 5: 137, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26998235
12.
Identification of modulators of autophagic flux in an image-based high content siRNA screen.
Autophagy
; 12(4): 713-26, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27050463
13.
SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor.
J Neurosci
; 22(22): 9721-32, 2002 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12427827
14.
Assessment of motor balance and coordination in mice using the balance beam.
J Vis Exp
; (49)2011 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21445033
15.
Integration of biochemical signalling in spines.
Nat Rev Neurosci
; 6(6): 423-34, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15928715
16.
Postsynaptic induction and presynaptic expression of group 1 mGluR-dependent LTD in the hippocampal CA1 region.
J Neurophysiol
; 87(3): 1395-403, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11877514