Detalhe da pesquisa
1.
Shift of the insoluble content of the proteome in the aging mouse brain.
Proc Natl Acad Sci U S A
; 120(45): e2310057120, 2023 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37906643
2.
Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1.
J Biol Chem
; 300(5): 107207, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38522514
3.
Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model.
J Neuroinflammation
; 19(1): 16, 2022 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35022041
4.
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons.
Purinergic Signal
; 18(4): 451-467, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35478453
5.
TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation.
J Biol Chem
; 295(12): 3808-3825, 2020 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32029478
6.
CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1.
J Biol Chem
; 294(10): 3744-3759, 2019 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30635404
7.
Passive immunotherapies targeting Aß and tau in Alzheimer's disease.
Neurobiol Dis
; 144: 105010, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32682954
8.
A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.
PLoS Pathog
; 14(1): e1006826, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29338055
9.
Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics.
Neurobiol Dis
; 124: 297-310, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30528257
10.
Regulation of Amyloid ß Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex.
J Biol Chem
; 291(42): 21945-21955, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27563063
11.
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.
Proc Natl Acad Sci U S A
; 111(9): 3620-5, 2014 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24550511
12.
Walking the tightrope: proteostasis and neurodegenerative disease.
J Neurochem
; 137(4): 489-505, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26872075
13.
Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.
Cell Mol Neurobiol
; 36(3): 377-81, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26908139
14.
From molecule to molecule and cell to cell: prion-like mechanisms in amyotrophic lateral sclerosis.
Neurobiol Dis
; 77: 257-65, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25701498
15.
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.
Acta Neuropathol
; 130(6): 845-61, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26374446
16.
The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-ß oligomer toxicity.
J Neurosci
; 33(42): 16552-64, 2013 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24133259
17.
The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.
J Biol Chem
; 288(52): 37241-55, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24225951
18.
An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS.
Nat Med
; 13(6): 754-9, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17486090
19.
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells.
Proc Natl Acad Sci U S A
; 108(39): 16398-403, 2011 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21930926
20.
Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells.
Open Biol
; 14(6): 230418, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38835240