Detalhe da pesquisa
1.
Vaccine Efficacy in Adults in a Respiratory Syncytial Virus Challenge Study.
N Engl J Med
; 386(25): 2377-2386, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35731653
2.
SARS-CoV-2 Human Challenge Studies - Establishing the Model during an Evolving Pandemic.
N Engl J Med
; 385(11): 961-964, 2021 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34289273
3.
The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics.
Respir Res
; 19(1): 123, 2018 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29929556
4.
Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults.
Sci Immunol
; 9(92): eadj9285, 2024 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38335268
5.
Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 controlled human infection study.
Lancet Microbe
; 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38703782
6.
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.
HGG Adv
; 5(3): 100300, 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38678364
7.
Quantification of clesrovimab, an investigational, half-life extended, anti-respiratory syncytial virus protein F human monoclonal antibody in the nasal epithelial lining fluid of healthy adults.
Biomed Pharmacother
; 169: 115851, 2023 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37976891
8.
Viral emissions into the air and environment after SARS-CoV-2 human challenge: a phase 1, open label, first-in-human study.
Lancet Microbe
; 4(8): e579-e590, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37307844
9.
Lack of association between HLA and asymptomatic SARS-CoV-2 infection.
medRxiv
; 2023 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38168184
10.
The role of public involvement in the design of the first SARS-CoV-2 human challenge study during an evolving pandemic.
Epidemics
; 41: 100626, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36088739
11.
Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults.
Nat Med
; 28(5): 1031-1041, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35361992
12.
Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis.
EBioMedicine
; 73: 103651, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34775220
13.
The manufacturing of human viral challenge agents for use in clinical studies to accelerate the drug development process.
BMC Res Notes
; 11(1): 620, 2018 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30157933
14.
Correction: Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model.
PLoS One
; 11(6): e0157211, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27280602
15.
Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model.
PLoS One
; 11(1): e0145902, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26761707
16.
A Tool for Investigating Asthma and COPD Exacerbations: A Newly Manufactured and Well Characterised GMP Wild-Type Human Rhinovirus for Use in the Human Viral Challenge Model.
PLoS One
; 11(12): e0166113, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27936016
17.
New antiviral drugs, vaccines and classic public health interventions against SARS coronavirus.
Antivir Chem Chemother
; 16(1): 13-21, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15739618
18.
A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV.
Antivir Chem Chemother
; 16(2): 129-34, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15889535
19.
Use of qualitative integrative cycler PCR (qicPCR) to identify optimal therapeutic dosing time-points in a Respiratory Syncytial Virus Human Viral Challenge Model (hVCM).
J Virol Methods
; 224: 83-90, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26335961
20.
Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge.
PLoS One
; 9(5): e93761, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24850536