RESUMO
Immunoglobulin deposition in alcoholic and non-alcoholic liver disease was studied using an indirect immunoperoxidase technique. A continuous pattern of IgA deposition, with IgA outlining the sinusoids, was shown to be a specific and sensitive marker for liver disease caused by alcohol in both cirrhotic and non-cirrhotic livers. The sensitivity was lowest in cases of alcoholic disease showing fatty change alone. In one case it was possible to show the absence of IgA in liver disease caused by a drug, which was histologically indistinguishable from alcoholic hepatitis.
Assuntos
Imunoglobulina A/análise , Hepatopatias Alcoólicas/imunologia , Fígado/imunologia , Fígado Gorduroso Alcoólico/imunologia , Fígado Gorduroso Alcoólico/patologia , Hepatite Alcoólica/imunologia , Hepatite Alcoólica/patologia , Humanos , Técnicas Imunoenzimáticas , Cirrose Hepática Alcoólica/imunologia , Cirrose Hepática Alcoólica/patologia , Estudos RetrospectivosRESUMO
Recorded in several species including humans, geophagia or soil eating has been observed in both wild and domesticated horses and has generally been regarded as an indication of nutritional deficiency or "boredom". Studies of soils consumed by different species have led to several theories as to the identity of soil constituents that stimulate geophagia. In this study, geochemical analysis of 13 equine geophagic sites from different parts of Australia was undertaken. Significantly larger concentrations of iron and copper were found in soil samples from geophagic sites when compared to paired control samples, suggesting that these elements provide the stimulus for geophagia.