Detalhe da pesquisa
1.
Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes.
J Neurosci
; 43(26): 4755-4774, 2023 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37286354
2.
Design, synthesis and evaluation of novel thieno[2,3d]pyrimidine derivatives as potent and specific RIPK2 inhibitors.
Bioorg Med Chem Lett
; 97: 129567, 2024 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38008339
3.
Structural Analysis of the OC43 Coronavirus 2'-O-RNA Methyltransferase.
J Virol
; 95(15): e0046321, 2021 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34011548
4.
Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein.
PLoS Pathog
; 16(12): e1009100, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33264373
5.
Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold.
Bioorg Med Chem Lett
; 76: 129010, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36184029
6.
Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites.
PLoS Pathog
; 15(8): e1007962, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31381608
7.
Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 Coronavirus.
Molecules
; 26(9)2021 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33946802
8.
A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha.
J Lipid Res
; 60(3): 683-693, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30626625
9.
Structural analysis of phosphatidylinositol 4-kinase IIIß (PI4KB) - 14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro.
J Struct Biol
; 200(1): 36-44, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28864297
10.
The crystal structure of the phosphatidylinositol 4-kinase IIα.
EMBO Rep
; 15(10): 1085-92, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25168678
11.
Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis.
Biochemistry
; 54(20): 3197-206, 2015 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25928210
12.
The high-resolution crystal structure of phosphatidylinositol 4-kinase IIß and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 7): 1555-63, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26143926
13.
Norbornane-based nucleoside and nucleotide analogues locked in North conformation.
Bioorg Med Chem
; 23(1): 184-91, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25435471
14.
Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase.
Structure
; 2024 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38781970
15.
Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.
Structure
; 32(4): 433-439.e4, 2024 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38325369
16.
Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity.
Proc Natl Acad Sci U S A
; 107(20): 9093-8, 2010 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20439761
17.
Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39.
Antiviral Res
; 216: 105663, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37421984
18.
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun
; 14(1): 2259, 2023 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37080993
19.
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.
Eur J Med Chem
; 260: 115717, 2023 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37598483
20.
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.
Neuropharmacology
; 222: 109297, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36341805