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1.

A variant in MCF2L is associated with osteoarthritis.

Day-Williams, Aaron G; Southam, Lorraine; Panoutsopoulou, Kalliope; Rayner, Nigel W; Esko, Tonu; Estrada, Karol; Helgadottir, Hafdis T; Hofman, Albert; Ingvarsson, Throvaldur; Jonsson, Helgi; Keis, Aime; Kerkhof, Hanneke J M; Thorleifsson, Gudmar; Arden, Nigel K; Carr, Andrew; Chapman, Kay; Deloukas, Panos; Loughlin, John; McCaskie, Andrew; Ollier, William E R; Ralston, Stuart H; Spector, Timothy D; Wallis, Gillian A; Wilkinson, J Mark; Aslam, Nadim; Birell, Fraser; Carluke, Ian; Joseph, John; Rai, Ashok; Reed, Mike; Walker, Kirsten; Doherty, Sally A; Jonsdottir, Ingileif; Maciewicz, Rose A; Muir, Kenneth R; Metspalu, Andres; Rivadeneira, Fernando; Stefansson, Kari; Styrkarsdottir, Unnur; Uitterlinden, Andre G; van Meurs, Joyce B J; Zhang, Weiya; Valdes, Ana M; Doherty, Michael; Zeggini, Eleftheria.

Am J Hum Genet ; 89(3): 446-50, 2011 Sep 09.

Artigo em Inglês | MEDLINE | ID: mdl-21871595

2.

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

Evangelou, Evangelos; Kerkhof, Hanneke J; Styrkarsdottir, Unnur; Ntzani, Evangelia E; Bos, Steffan D; Esko, Tonu; Evans, Daniel S; Metrustry, Sarah; Panoutsopoulou, Kalliope; Ramos, Yolande F M; Thorleifsson, Gudmar; Tsilidis, Konstantinos K; Arden, Nigel; Aslam, Nadim; Bellamy, Nicholas; Birrell, Fraser; Blanco, Francisco J; Carr, Andrew; Chapman, Kay; Day-Williams, Aaron G; Deloukas, Panos; Doherty, Michael; Engström, Gunnar; Helgadottir, Hafdis T; Hofman, Albert; Ingvarsson, Thorvaldur; Jonsson, Helgi; Keis, Aime; Keurentjes, J Christiaan; Kloppenburg, Margreet; Lind, Penelope A; McCaskie, Andrew; Martin, Nicholas G; Milani, Lili; Montgomery, Grant W; Nelissen, Rob G H H; Nevitt, Michael C; Nilsson, Peter M; Ollier, William Er; Parimi, Neeta; Rai, Ashok; Ralston, Stuart H; Reed, Mike R; Riancho, Jose A; Rivadeneira, Fernando; Rodriguez-Fontenla, Cristina; Southam, Lorraine; Thorsteinsdottir, Unnur; Tsezou, Aspasia; Wallis, Gillian A.

Ann Rheum Dis ; 73(12): 2130-6, 2014 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23989986

3.

No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls.

Hudson, Gavin; Panoutsopoulou, Kalliope; Wilson, Ian; Southam, Lorraine; Rayner, Nigel W; Arden, Nigel; Birrell, Fraser; Carluke, Ian; Carr, Andrew; Chapman, Kay; Deloukas, Panos; Doherty, Michael; McCaskie, Andrew; Ollier, William E R; Ralston, Stuart H; Reed, Mike R; Spector, Tim D; Valdes, Ana M; Wallis, Gillian A; Wilkinson, J Mark; Zeggini, Eleftheria; Samuels, David C; Loughlin, John; Chinnery, Patrick F.

Ann Rheum Dis ; 72(1): 136-9, 2013 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22984172

4.

Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data.

Elliott, Katherine S; Chapman, Kay; Day-Williams, Aaron; Panoutsopoulou, Kalliope; Southam, Lorraine; Lindgren, Cecilia M; Arden, Nigel; Aslam, Nadim; Birrell, Fraser; Carluke, Ian; Carr, Andrew; Deloukas, Panos; Doherty, Michael; Loughlin, John; McCaskie, Andrew; Ollier, William E R; Rai, Ashok; Ralston, Stuart; Reed, Mike R; Spector, Timothy D; Valdes, Ana M; Wallis, Gillian A; Wilkinson, Mark; Zeggini, Eleftheria.

Ann Rheum Dis ; 72(6): 935-41, 2013 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-22956599

5.

Defining the power limits of genome-wide association scan meta-analyses.

Chapman, Kay; Ferreira, Teresa; Morris, Andrew; Asimit, Jennifer; Zeggini, Eleftheria.

Genet Epidemiol ; 35(8): 781-9, 2011 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-21922540

6.

Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations.

Meulenbelt, Ingrid; Chapman, Kay; Dieguez-Gonzalez, Rebeca; Shi, Dongquan; Tsezou, Aspasia; Dai, Jin; Malizos, Konstantinos N; Kloppenburg, Margreet; Carr, Andrew; Nakajima, Masahiro; van der Breggen, Ruud; Lakenberg, Nico; Gomez-Reino, Juan J; Jiang, Qing; Ikegawa, Shiro; Gonzalez, Antonio; Loughlin, John; Slagboom, Eline P.

Hum Mol Genet ; 18(8): 1518-23, 2009 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-19181678

7.

Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility.

Meulenbelt, Ingrid; Bos, Steffan D; Chapman, Kay; van der Breggen, Ruud; Houwing-Duistermaat, Jeanine J; Kremer, Dennis; Kloppenburg, Margreet; Carr, Andrew; Tsezou, Aspasia; González, Antonio; Loughlin, John; Slagboom, P Eline.

Ann Rheum Dis ; 70(1): 164-7, 2011 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-20724312

8.

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.

Evangelou, Evangelos; Valdes, Ana M; Kerkhof, Hanneke J M; Styrkarsdottir, Unnur; Zhu, Yanyan; Meulenbelt, Ingrid; Lories, Rik J; Karassa, Fotini B; Tylzanowski, Przemko; Bos, Steffan D; Akune, Toru; Arden, Nigel K; Carr, Andrew; Chapman, Kay; Cupples, L Adrienne; Dai, Jin; Deloukas, Panos; Doherty, Michael; Doherty, Sally; Engstrom, Gunnar; Gonzalez, Antonio; Halldorsson, Bjarni V; Hammond, Christina L; Hart, Deborah J; Helgadottir, Hafdis; Hofman, Albert; Ikegawa, Shiro; Ingvarsson, Thorvaldur; Jiang, Qing; Jonsson, Helgi; Kaprio, Jaakko; Kawaguchi, Hiroshi; Kisand, Kalle; Kloppenburg, Margreet; Kujala, Urho M; Lohmander, L Stefan; Loughlin, John; Luyten, Frank P; Mabuchi, Akihiko; McCaskie, Andrew; Nakajima, Masahiro; Nilsson, Peter M; Nishida, Nao; Ollier, William E R; Panoutsopoulou, Kalliope; van de Putte, Tom; Ralston, Stuart H; Rivadeneira, Fernado; Saarela, Janna; Schulte-Merker, Stefan.

Ann Rheum Dis ; 70(2): 349-55, 2011 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-21068099

9.

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility.

Chapman, Kay; Takahashi, Atsushi; Meulenbelt, Ingrid; Watson, Chris; Rodriguez-Lopez, Julio; Egli, Rainer; Tsezou, Aspasia; Malizos, Konstantinos N; Kloppenburg, Margreet; Shi, Dongquan; Southam, Lorraine; van der Breggen, Ruud; Donn, Rachelle; Qin, Jianghui; Doherty, Michael; Slagboom, P Eline; Wallis, Gillian; Kamatani, Naoyuki; Jiang, Qing; Gonzalez, Antonio; Loughlin, John; Ikegawa, Shiro.

Hum Mol Genet ; 17(10): 1497-504, 2008 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-18299287

10.

Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis.

Wilkins, James M; Southam, Lorraine; Mustafa, Zehra; Chapman, Kay; Loughlin, John.

BMC Med Genet ; 10: 141, 2009 Dec 19.

Artigo em Inglês | MEDLINE | ID: mdl-20021689

11.

Finer linkage mapping of a primary hip osteoarthritis susceptibility locus on chromosome 6.

Loughlin, John; Mustafa, Zehra; Dowling, Barbara; Southam, Lorraine; Marcelline, Lucy; Räinä, S Susanna; Ala-Kokko, Leena; Chapman, Kay.

Eur J Hum Genet ; 10(9): 562-8, 2002 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-12173034

12.

Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies.

Rodriguez-Fontenla, Cristina; Calaza, Manuel; Evangelou, Evangelos; Valdes, Ana M; Arden, Nigel; Blanco, Francisco J; Carr, Andrew; Chapman, Kay; Deloukas, Panos; Doherty, Michael; Esko, Tõnu; Garcés Aletá, Carlos M; Gomez-Reino Carnota, Juan J; Helgadottir, Hafdis; Hofman, Albert; Jonsdottir, Ingileif; Kerkhof, Hanneke J M; Kloppenburg, Margreet; McCaskie, Andrew; Ntzani, Evangelia E; Ollier, William E R; Oreiro, Natividad; Panoutsopoulou, Kalliope; Ralston, Stuart H; Ramos, Yolande F; Riancho, Jose A; Rivadeneira, Fernando; Slagboom, P Eline; Styrkarsdottir, Unnur; Thorsteinsdottir, Unnur; Thorleifsson, Gudmar; Tsezou, Aspasia; Uitterlinden, André G; Wallis, Gillian A; Wilkinson, J Mark; Zhai, Guangju; Zhu, Yanyan; Felson, David T; Ioannidis, John P A; Loughlin, John; Metspalu, Andres; Meulenbelt, Ingrid; Stefansson, Kari; van Meurs, Joyce B; Zeggini, Eleftheria; Spector, Timothy D; Gonzalez, Antonio.

Arthritis Rheumatol ; 66(4): 940-9, 2014 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-24757145

13.

Genetic factors in OA pathogenesis.

Chapman, Kay; Valdes, Ana M.

Bone ; 51(2): 258-64, 2012 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-22178404

14.

The effect of genome-wide association scan quality control on imputation outcome for common variants.

Southam, Lorraine; Panoutsopoulou, Kalliope; Rayner, N William; Chapman, Kay; Durrant, Caroline; Ferreira, Teresa; Arden, Nigel; Carr, Andrew; Deloukas, Panos; Doherty, Michael; Loughlin, John; McCaskie, Andrew; Ollier, William E R; Ralston, Stuart; Spector, Timothy D; Valdes, Ana M; Wallis, Gillian A; Wilkinson, J Mark; Marchini, Jonathan; Zeggini, Eleftheria.

Eur J Hum Genet ; 19(5): 610-4, 2011 May.

Artigo em Inglês | MEDLINE | ID: mdl-21267008

15.

Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism.

Egli, Rainer J; Southam, Lorraine; Wilkins, James M; Lorenzen, Inken; Pombo-Suarez, Manuel; Gonzalez, Antonio; Carr, Andrew; Chapman, Kay; Loughlin, John.

Arthritis Rheum ; 60(7): 2055-64, 2009 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-19565498

16.

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand.

Evangelou, Evangelos; Chapman, Kay; Meulenbelt, Ingrid; Karassa, Fotini B; Loughlin, John; Carr, Andrew; Doherty, Michael; Doherty, Sally; Gómez-Reino, Juan J; Gonzalez, Antonio; Halldorsson, Bjarni V; Hauksson, Valdimar B; Hofman, Albert; Hart, Deborah J; Ikegawa, Shiro; Ingvarsson, Thorvaldur; Jiang, Qing; Jonsdottir, Ingileif; Jonsson, Helgi; Kerkhof, Hanneke J M; Kloppenburg, Margreet; Lane, Nancy E; Li, Jia; Lories, Rik J; van Meurs, Joyce B J; Näkki, Annu; Nevitt, Michael C; Rodriguez-Lopez, Julio; Shi, Dongquan; Slagboom, P Eline; Stefansson, Kari; Tsezou, Aspasia; Wallis, Gillian A; Watson, Christopher M; Spector, Tim D; Uitterlinden, Andre G; Valdes, Ana M; Ioannidis, John P A.

Arthritis Rheum ; 60(6): 1710-21, 2009 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-19479880

17.

Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.

Pointon, Jennifer J; Chapman, Kay; Harvey, David; Sims, Anne-Marie; Bradbury, Linda; Laiho, Kari; Kauppi, Markku; Kaarela, Kalevi; Tuomilehto, Jaakko; Brown, Matthew A; Wordsworth, B Paul.

J Rheumatol ; 35(8): 1609-12, 2008 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-18634146

18.

Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee.

Valdes, Ana M; Loughlin, John; Oene, Mark Van; Chapman, Kay; Surdulescu, Gabriela L; Doherty, Michael; Spector, Tim D.

Arthritis Rheum ; 56(1): 137-46, 2007 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-17195216

19.

A novel LEMD3 mutation common to patients with osteopoikilosis with and without melorheostosis.

Couto, Ana R; Bruges-Armas, Jacome; Peach, Chris A; Chapman, Kay; Brown, Matthew A; Wordsworth, B Paul; Zhang, Yun.

Calcif Tissue Int ; 81(2): 81-4, 2007 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-17622481

20.

An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage.

Southam, Lorraine; Rodriguez-Lopez, Julio; Wilkins, James M; Pombo-Suarez, Manuel; Snelling, Sarah; Gomez-Reino, Juan J; Chapman, Kay; Gonzalez, Antonio; Loughlin, John.

Hum Mol Genet ; 16(18): 2226-32, 2007 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-17616513

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