Detalhe da pesquisa
1.
An asymmetric sp3-sp3 cross-electrophile coupling using 'ene'-reductases.
Nature
; 610(7931): 302-307, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35952713
2.
Multifunctional biocatalyst for conjugate reduction and reductive amination.
Nature
; 604(7904): 86-91, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35388195
3.
Thermostable in vitro transcription-translation compatible with microfluidic droplets.
Microb Cell Fact
; 23(1): 169, 2024 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38858677
4.
The Impact of Metagenomics on Biocatalysis.
Angew Chem Int Ed Engl
; 63(21): e202402316, 2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38494442
5.
Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes.
J Am Chem Soc
; 145(21): 11866-11874, 2023 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37199445
6.
An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir.
J Am Chem Soc
; 144(9): 3761-3765, 2022 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35224970
7.
Synthesis of Stereoenriched Piperidines via Chemo-Enzymatic Dearomatization of Activated Pyridines.
J Am Chem Soc
; 144(46): 21088-21095, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36350999
8.
Chemoenzymatic Cascades for the Enantioselective Synthesis of ß-Hydroxysulfides Bearing a Stereocentre at the C-O or C-S Bond by Ketoreductases.
Angew Chem Int Ed Engl
; 61(31): e202202363, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35576553
9.
Synthesis of Pharmaceutically Relevant 2-Aminotetralin and 3-Aminochroman Derivatives via Enzymatic Reductive Amination.
Angew Chem Int Ed Engl
; 60(46): 24456-24460, 2021 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34478225
10.
Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination.
Angew Chem Int Ed Engl
; 60(16): 8717-8721, 2021 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33555620
11.
Enantioselective Synthesis of α-Thiocarboxylic Acids by Nitrilase Biocatalysed Dynamic Kinetic Resolution of α-Thionitriles.
Chemistry
; 26(46): 10422-10426, 2020 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32239730
12.
Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides.
Org Biomol Chem
; 18(16): 3142-3148, 2020 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32255449
13.
Fluorogenic kinetic assay for high-throughput discovery of stereoselective ketoreductases relevant to pharmaceutical synthesis.
Bioorg Med Chem
; 26(7): 1320-1326, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28551096
14.
Photo-biocatalytic One-Pot Cascades for the Enantioselective Synthesis of 1,3-Mercaptoalkanol Volatile Sulfur Compounds.
Angew Chem Int Ed Engl
; 57(20): 5803-5807, 2018 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29533509
15.
A method for the systematic selection of enzyme panel candidates by solving the maximum diversity problem.
Biosystems
; 236: 105105, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38160995
16.
In Search of Complementary Extraction Methods for Comprehensive Coverage of the Escherichia coli Metabolome.
Metabolites
; 13(9)2023 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37755290
17.
Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes.
Res Sq
; 2023 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36865242
18.
A Coupled Ketoreductase-Diaphorase Assay for the Detection of Polyethylene Terephthalate-Hydrolyzing Activity.
ChemSusChem
; 15(9): e202102750, 2022 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35315974
19.
Crystal structures of a family 8 polysaccharide lyase reveal open and highly occluded substrate-binding cleft conformations.
Proteins
; 79(3): 965-74, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21287626
20.
Rapid Screening of Diverse Biotransformations for Enzyme Evolution.
JACS Au
; 1(4): 508-516, 2021 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34056634