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Construction of heterojunctions is an effective strategy to enhanced electrocatalytic oxygen evolution reaction (OER), but the structural evolution of the active phases and synergistic mechanism still lack in-depth understanding. Here, an FeOOH/Ni3S2 heterostructure supported on nickel foam (NF) through a two-step hydrothermal-chemical etching method is reported. In situ Raman spectroscopy study of the surface reconstruction behaviors of FeOOH/Ni3S2/NF indicates that Ni3S2 can be rapidly converted to NiOOH, accompanied by the phase transition from α-FeOOH to ß-FeOOH during the OER process. Importantly, a deep analysis of NiâO bond reveals that the phase transition of FeOOH can regulate the lattice disorder of NiOOH for improved catalytic activity. Density functional theory (DFT) calculations further confirm that NiOOH/FeOOH heterostructure possess strengthened adsorption for O-containing intermediates, as well as lower energy barrier toward the OER. As a result, FeOOH/Ni3S2/NF exhibits promising OER activity and stability in alkaline conditions, requiring an overpotential of 268 mV @ 100 mA cm-2 and long-term stability over 200 h at a current density of 200 mA cm-2. This work provides a new perspective for understanding the synergistic mechanism of heterogeneous electrocatalysts during the OER process.
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Main group element-based materials are emerging catalysts for ammonia (NH3 ) production via a sustainable electrochemical nitrogen reduction reaction (N2 RR) pathway under ambient conditions. However, their N2 RR performances are less explored due to the limited active behavior and unclear mechanism. Here, an aluminum-based defective metal-organic framework (MOF), aluminum-fumarate (Al-Fum), is investigated. As a proof of concept, the pristine Al-Fum MOF is synthesized by the solvothermal reaction process, and the defect engineering method namely solvent-assisted linker exchange, is applied to create the defective Al sites. The defective Al sites play an important role in ensuring the N2 RR activity for defective Al-Fum. It is found that only the defective Al-Fum enables stable and effective electrochemical N2 RR, in terms of the highest production rate of 53.9 µg(NH3 ) h-1 mgcat -1 (in 0.4 m K2 SO4 ) and the Faradaic efficiency of 73.8% (in 0.1 m K2 SO4 ) at -0.15 V vs reversible hydrogen electrode) under ambient conditions. Density functional theory calculations confirm that the N2 activation can be achieved on the defective Al sites. Such sites also allow the subsequent protonation process via the alternating associative mechanism. This defect characteristic gives the main group Al-based MOFs the ability to serve as promising electrocatalysts for N2 RR and other attractive applications.
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This paper reports an important conclusion that self-diffusion is not a necessary condition for inducing Turing patterns, while taxis could establish complex pattern phenomena. We investigate pattern formation in a zooplankton-phytoplankton model incorporating phytoplankton-taxis, where phytoplankton-taxis describes the zooplankton that tends to move toward the high-densities region of the phytoplankton population. By using the phytoplankton-taxis sensitivity coefficient as the Turing instability threshold, one shows that the model exhibits Turing instability only when repulsive phytoplankton-taxis is added into the system, while the attractive-type phytoplankton-taxis cannot induce Turing instability of the system. In addition, the system does not exhibit Turing instability when the phytoplankton-taxis disappears. Numerically, we display the complex patterns in 1D, 2D domains and on spherical and zebra surfaces, respectively. In summary, our results indicate that the phytoplankton-taxis plays a pivotal role in giving rise to the Turing pattern formation of the model. Additionally, these theoretical and numerical results contribute to our understanding of the complex interaction dynamics between zooplankton and phytoplankton populations.
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Modelos Biológicos , Fitoplâncton , Zooplâncton , Animais , Zooplâncton/fisiologia , Fitoplâncton/fisiologia , Simulação por Computador , Dinâmica não Linear , Ecossistema , Plâncton/fisiologia , Dinâmica PopulacionalRESUMO
Based on the growth-promoting effect of plant growth promoting bacteria on plants and the mobilization of Cd by citric acid, an experiment was designed in which the combined treatment of Bacillus megaterium and citric acid promoted ryegrass to repair Cd-contaminated soil. This study aimed to evaluate the effects of different treatments on the antioxidant enzyme activity, photosynthesis intensity, Cd accumulation, and rhizosphere cadmium migration under cadmium contamination conditions. And the soil morphology and structure changes were studied by infrared spectroscopy FourierTransformInfrared(FT-IR) and scanning electron microscope Energy Dispersive Spectrometer(SEM-EDS) before and after different treatments. The results show that the combined treatment of Bacillus megaterium and citric acid significantly improved the oxidative stress defense and plant photosynthesis and increased of rye biomass. rye biomass 1.28 times higher than CK treatment. Joint treatment significantly increased the amount of shoot accumulation of Cd, 2.31 times higher than CK treatment, increased the migration and accumulation of cadmium. FTIR and SEM-EDS also showed that the organic constituents such as O-H, C-O and C-N in soils as a major mechanism for mobilization of the heavy metal Cd. Thus, the combined treatment of Bacillus megaterium and citric acid can promote plant growth, improve the damage to ryegrass caused by single organic acid addition, and improve the plant extraction efficiency, which is a feasible way to repair Cd-contaminated soil through activated extraction system.
The novelty of this study is the combined application of bacteria and chelating agents to ryegrass to improve phytoremediation efficiency. Bacillus giganosus has a good role in promoting the growth of ryegrass. As citrate, a small molecule chelate, can activate heavy metal cadmium and detoxify heavy metals, so it was selected. This study revealed in detail the response of ryegrass to the heavy metal Cd after exogenous addition of Bacillus gigansus and citrate, which is important for the application of cadmium removal by phytoremediation.
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Lolium , Metais Pesados , Poluentes do Solo , Cádmio/metabolismo , Biodegradação Ambiental , Lolium/metabolismo , Ácido Cítrico/farmacologia , Espectroscopia de Infravermelho com Transformada de Fourier , Poluentes do Solo/metabolismo , Metais Pesados/análise , Solo/química , Bactérias/metabolismoRESUMO
Glycerol is a byproduct of biodiesel production. Selective photoelectrochemical oxidation of glycerol to high value-added chemicals offers an economical and sustainable approach to transform renewable feedstock as well as store green energy at the same time. In this work, we synthesized monoclinic WO3 nanosheets with exposed (002) facets, which could selectively oxidize glycerol to glyceric acid (GLYA) with a photocurrent density of 1.7â mA cm-2 , a 73 % GLYA selectivity and a 39 % GLYA Faradaic efficiency at 0.9â V vs. reversible hydrogen electrode (RHE) under AM 1.5G illumination (100â mW cm-2 ). Compared to (200) facets exposed WO3 , a combination of experiments and theoretical calculations indicates that the superior performance of selective glycerol oxidation mainly originates from the better charge separation and prolonged carrier lifetime resulted from the plenty of surface trapping states, lower energy barrier of the glycerol-to-GLYA reaction pathway, more abundant active sites and stronger oxidative ability of photogenerated holes on the (002) facets exposed WO3 . Our findings show great potential to significantly contribute to the sustainable and environmentally friendly chemical processes via designing high performance photoelectrochemical cell via facet engineering for renewable feedstock transformation.
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Laser-driven phase transition of 2D transition metal dichalcogenides has attracted much attention due to its high flexibility and rapidity. However, there are some limitations during the laser irradiation process, especially the unsatisfied surface ablation, the inability of nanoscale phase patterning, and the unexploited physical properties of new phase. In this work, the well-controlled femtosecond (fs) laser-driven transformation from the metallic 2M-WS2 to the semiconducting 2H-WS2 is reported, which is confirmed to be a single-crystal to single-crystal transition without layer thinning or obvious ablation. Moreover, a highly ordered 2H/2M nano-periodic phase transition with a resolution of ≈435 nm is achieved, breaking through the existing size bottleneck of laser-driven phase transition, which is attributed to the selective deposition of plasmon energy induced by fs laser. It is also demonstrated that the achieved 2H-WS2 after laser irradiation contains rich sulfur vacancies, which exhibits highly competitive ammonia gas sensing performance, with a detection limit below 0.1 ppm and a fast response/recovery time of 43/67 s at room temperature. This study provides a new strategy for the preparation of the phase-selective transition homojunction and high-performance applications in electronics.
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Two-dimensional (2D) transition-metal dichalcogenides (TMDs) have emerged as promising materials for surface-enhanced Raman scattering (SERS) due to their unique electronic, optical, and mechanical properties. In this Perspective, we briefly introduce the fundamental properties, crystal-phase configurations, and phase transition strategies of TMDs materials. We then discuss the importance of the crystal phase in determining the SERS effect of TMDs, highlighting recent advances in phase-engineering approaches to affording remarkable SERS performance. By considering the current challenges and future directions for improving the crystal-phase engineering of TMDs in SERS, we also offer new insights into the design and synthesis of more promising TMD-based SERS substrates.
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BACKGROUND: Studies on aspirin's effects on metabolic-associated fatty liver disease (MAFLD) are limited. The aim of this study was to assess the association between aspirin and all-cause and cardiovascular disease (CVD) mortality in individuals with MAFLD. METHODS: Data were acquired from the National Health And Nutrition Examination Survey (NHANES) III. MAFLD diagnosis was consistent with that of international expert consensus. The independent association between aspirin and all-cause and CVD mortality in participants with MAFLD was evaluated by multiple Cox regression. Stratified analyses and interaction tests were performed to investigate whether covariates modified the association between aspirin and MAFLD mortality. RESULTS: Of 4594 eligible participants, 3,162 (68.83%) never took aspirin (0 times/month), 962 (20.94%) took it occasionally (1-14 times/month) and 470 (10.23%) took it regularly (≥15 times/month). Multiple cox regression showed that aspirin was not associated with overall mortality for MAFLD individuals. Stratified analysis revealed that in middle-aged (45-59 years) participants with MAFLD, occasional aspirin use was associated with low all-cause mortality risk (HR = 0.61, 95% CI = 0.43-0.86), while there was no significant association between aspirin and all-cause mortality among the young or the elderly. CONCLUSIONS: We found that the association between aspirin and all-cause MAFLD mortality varies by both age and frequency of administration. More prospective studies are needed to explore aspirin's influence on MALFD mortality.
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Doenças Cardiovasculares , Hepatopatia Gordurosa não Alcoólica , Idoso , Pessoa de Meia-Idade , Humanos , Inquéritos Nutricionais , Aspirina/efeitos adversos , Hepatopatia Gordurosa não Alcoólica/complicaçõesRESUMO
With the increase in cadmium (Cd) release into the environment, it is necessary to find appropriate solutions to reduce soil Cd pollution. Microorganisms are a green and effective means for the remediation of Cd-contaminated soil. In this study, in a Cd-contaminated farmland, we screened and identified novel Cd-resistant strains, Paenarthrobactor nitroguajacolicus, Lysinibacillus fusiformis, Bacillus licheniformis, and Methyllobacium brachiatum, with minimum inhibitory concentrations of 100, 100, 50, and 50 mg/L, respectively, and added them each to pots containing Cd-contaminated rape plants to explore their remediation ability. The results showed that treatment with each of the four strains significantly increased the abundance of Nitrospirae, Firmicutes, Verrucomicrobia, and Patescibacterium in the rhizosphere soil of the plants. This led to changes in soil physical and chemical indices; pH; and available phosphorus, urease, and catalase activities, which were significantly negatively correlated with bioavailable Cd, reducing 28.74-58.82 % Cd enrichment to plants and 23.72-43.79 % Cd transport within plants, and reducing 5.52-10.68 % available cadmium in soil, effectively reducing the biotoxicity of Cd. Thus, this study suggests microbial remediation as a reliable option, forming a basis for the remediation of Cd-contaminated soil.
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Cádmio , Poluentes do Solo , Cádmio/análise , Biodegradação Ambiental , Poluentes do Solo/análise , Bactérias , Solo/químicaRESUMO
This study tracked the longstanding effect of childhood adversities on health status over the course of a life. This study used the data from China Health and Retirement Longitudinal Study which was a nationally representative survey and documented the generation who had arrived in the middle- and old-age phase and experienced the difficult time in the early founding of PR China in their childhood. Results shown the significant associations between multiple forms of children adversities (economic distress, child neglect, child abuse, lack of friends, parental mental health problems) and health status in adolescence (from 0.068 to 0.102, p<0.01), and health status in mid and late adulthood, including self-rated general health problems (from 0.039 to 0.061, p<0.01), chronic conditions (from 0.014 to 0.120, p<0.01 except for lack of friends), body aches (from 0.016 to 0.062, p<0.01 except for child neglect), and depression (from 0.047 to 0.112, p<0.01). Meanwhile, results also shown an underlying pathway (i.e., health status in adolescence) linking childhood adversities and health status in mid and late adulthood. Results suggested that the experience of multiple forms of adversities in childhood represented a substantial source of health risk throughout life.
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Nível de Saúde , Longevidade , Adolescente , Humanos , Criança , Adulto , Estudos Longitudinais , Inquéritos e Questionários , China , Fatores de RiscoRESUMO
Herein, with two-dimensional (2D) borocarbonitride (BCN) as a metal- and plasmon-free surface-enhanced Raman scattering (SERS) platform, we demonstrate a band structure engineering strategy to facilitate the charge transfer process for an enhanced SERS response. Especially, when the conduction band of the BCN substrate is tuned to align with the LUMO of the target molecule, remarkable SERS performance is achieved, ascribed to the borrowing effect from the vibronic coupling of resonances through the Herzberg-Teller coupling term. Meanwhile, fluorescence quenching is achieved due to the efficient charge transfer between the BCN substrate and target molecule. Consequently, BCN can accurately detect 20 kinds of trace chemical and bioactive analytes. Moreover, BCN exhibits excellent thermal and chemical stability, which can not only withstand high-temperature (300 °C) heating in the air but also resist long-term corrosion in harsh acid (pH = 0, HCl) and base (pH = 14, NaOH). This work provides new insight into band structure engineering in promoting the SERS performance of plasmon- and metal-free semiconductor substrates.
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Metais , Análise Espectral Raman , Metais/química , Semicondutores , Análise Espectral Raman/métodos , VibraçãoRESUMO
First discovered in Wuhan, China, SARS-CoV-2 is a highly pathogenic novel coronavirus, which rapidly spread globally and became a pandemic with no vaccine and limited distinctive clinical drugs available till March 13th, 2020. Ribonucleic Acid interference (RNAi) technology, a gene-silencing technology that targets mRNA, can cause damage to RNA viruses effectively. Here, we report a new efficient small interfering RNA (siRNA) design method named Simple Multiple Rules Intelligent Method (SMRI) to propose a new solution of the treatment of COVID-19. To be specific, this study proposes a new model named Base Preference and Thermodynamic Characteristic model (BPTC model) indicating the siRNA silencing efficiency and a new index named siRNA Extended Rules index (SER index) based on the BPTC model to screen high-efficiency siRNAs and filter out the siRNAs that are difficult to take effect or synthesize as a part of the SMRI method, which is more robust and efficient than the traditional statistical indicators under the same circumstances. Besides, to silence the spike protein of SARS-CoV-2 to invade cells, this study further puts forward the SMRI method to search candidate high-efficiency siRNAs on SARS-CoV-2's S gene. This study is one of the early studies applying RNAi therapy to the COVID-19 treatment. According to the analysis, the average value of predicted interference efficiency of the candidate siRNAs designed by the SMRI method is comparable to that of the mainstream siRNA design algorithms. Moreover, the SMRI method ensures that the designed siRNAs have more than three base mismatches with human genes, thus avoiding silencing normal human genes. This is not considered by other mainstream methods, thereby the five candidate high-efficiency siRNAs which are easy to take effect or synthesize and much safer for human body are obtained by our SMRI method, which provide a new safer, small dosage and long efficacy solution for the treatment of COVID-19. Supplementary Information: The online version contains supplementary material available at 10.1007/s11390-021-0826-x.
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With ever-increasing energy consumption and continuous rise in atmospheric CO2 concentration, electrochemical reduction of CO2 into chemicals/fuels is becoming a promising yet challenging solution. Sn-based materials are identified as attractive electrocatalysts for the CO2 reduction reaction (CO2 RR) to formate but suffer from insufficient selectivity and activity, especially at large cathodic current densities. Herein, we demonstrate that Cu-doped SnS2 nanoflowers can undergo in situ dynamic restructuring to generate catalytically active S-doped Cu/Sn alloy for highly selective electrochemical CO2 RR to formate over a wide potential window. Theoretical thermodynamic analysis of reaction energetics indicates that the optimal electronic structure of the Sn active site can be regulated by both S-doping and Cu-alloying to favor formate formation, while the CO and H2 pathways will be suppressed. Our findings provide a rational strategy for electronic modulation of metal active site(s) for the design of active and selective electrocatalysts towards CO2 RR.
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In this paper, sufficient conditions of Turing instability are established for general delayed reaction-diffusion-chemotaxis models with no-flux boundary conditions. In particular, we address the difficulty brought about by the time delay in investigating the Turing instability. These models involve the time delay parameter τ and the general density (concentration) function in chemotaxis terms with the chemotaxis parameter χ. Theoretical results reveal that the time delay parameter τ could determine the stability of positive equilibrium for ordinary differential equations, while the chemotaxis parameter χ could describe the stability of positive equilibrium for partial differential equations. In this fashion, the general conditions of Turing instability are presented. To confirm their validity, the delayed chemotaxis-type predator-prey model and the phytoplankton-zooplankton model are considered. It is found that these two models admit Turing instability, and the numerical results are in good agreement with the theoretical analysis. The obtained results are helpful in the application of the Turing pattern in models with time delay and chemotaxis.
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Although the issue of embodied pollutants in China's supply chains has garnered increasing attention, the dynamic changes occurring within them are unclear. Several existing studies analyze one-year or short-term data in supply chain. China's overall CH4 emissions have risen from 41.1 Tg in 2000 to 60 Tg in 2020, so conducting long-term analyses can yield a deeper understanding of the dynamic changes across the entire supply chain from production to consumption. This study uses the environmentally extended input-output analysis (EEIOA) and structural path analysis (SPA) methods to investigate the dynamic variation of China's embodied CH4 emissions in 20 industry sectors from 2000 to 2020, aiming to determine the key supply chain and key sectors. The results reveal that from the final demand perspective, consumption, investment and export drove 52.1%, 32%, and 15.9% of embodied CH4 emissions in 2020. The sector with the highest embodied CH4 emissions has changed from "Agriculture" in 2000 to "Construction" in 2010 to "Other service and activities" in 2020. The top listed supply chain path of embodied CH4 emissions has also evolved (starting from production to consumption) from "Agriculture â Rural consumption" in 2000 to "Agriculture â Food and tobacco â Urban consumption" in 2010 to "Agriculture â Urban consumption" in 2020. Notably, the high-ranked path, "Agriculture â Food and tobacco â Rural consumption", shows that the embodied CH4 emission flowing between agriculture and the food industry cannot be ignored. The supply chain path "Coal Mining â Nonmetal Mineral Products â Construction â Capital Formation" has risen from 17th in 2000 to 3rd in 2020. Thus, it is necessary to control CH4 emissions from sectors upstream, which are predominantly influenced by the construction industry, and a coordinated effort between sectors is also required to effectively reduce emissions. By 2020, the CH4 emissions driven by urban consumption were 3.1 times that of rural consumption. This study provides a comprehensive analysis of China's supply chain over the past two decades. In particular, it suggests policy interventions by controlling critical supply chain paths and key sectors associated with embodied CH4 emission, thereby facilitating the coordinated reduction of anthropogenic CH4 emissions.
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BACKGROUND: Preserved ratio impaired spirometry (PRISm) is a type of abnormal lung function. PRISm and mortality have been explored in several studies, but a comprehensive evaluation of the associations is limited. The current study aims to conduct a systematic review and meta-analysis in order to investigate the mortality and cardiovascular diseases in patients with PRISm. METHODS: PubMed, Embase, and Web of Science databases, as well as gray literature sources, were searched for relevant studies published up to 7 September 2023 without language restrictions. This review included all published observational cohort studies that investigated the association of PRISm with mortality in the general population, as well as subgroup analyses in smokers and pre-bronchodilation spirometry studies. The outcomes of interest were all-cause mortality, cardiovascular mortality, and respiratory-related mortality. The Newcastle-Ottawa scale assessed study quality. Sensitivity and subgroup analyses explored heterogeneity and robustness. Publication bias was assessed with Egger's and Begg's tests. RESULTS: Overall, eight studies were included in this meta-analysis. The pooled HR was 1.60 (95% CI, 1.48-1.74) for all-cause mortality, 1.68 (95% CI, 1.46-1.94) for CVD mortality, and 3.09 (95% CI, 1.42-6.71) for respiratory-related mortality in PRISm group compared to normal group. In the subgroup analysis, participants with PRISm had a higher effect (HR, 2.11; 95% CI, 1.74-2.54) on all-cause mortality among smokers relative to participants with normal spirometry. Furthermore, the association between PRISm and mortality risk was consistent across several sensitivity analyses. CONCLUSIONS: People with PRISm were associated with an increased risk of all-cause mortality, CVD mortality, and respiratory-related mortality as compared to those with normal lung function in the general population. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42023426872.
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Doenças Cardiovasculares , Espirometria , Humanos , Doenças Cardiovasculares/mortalidade , Causas de MorteRESUMO
In recent years, two-dimensional (2D) transition metal dichalcogenides (TMDCs) have been widely recognized as an ideal platform for surface-enhanced Raman scattering (SERS). Given their rich structural phases, phase transformation in 2D TMDCs is an efficient strategy to tailor their SERS performance. In this paper, we present the great SERS performance of multilayer 2M-WS2 and then investigate the effect of its phase transformation on SERS performance. It is observed that multilayer 2M-WS2 nanosheets undergo a thermally induced single-crystal phase transition from 2M-WS2 to 2H-WS2 upon thermal annealing or laser treatment. Distinguishing from the commercially available pure 2H-WS2 (P-2H-WS2), 2H-WS2 obtained by annealing and laser treatment still retain SERS properties comparable to those of 2M-WS2, among which the detection limits for CV molecules (10-8 M) are 3 orders of magnitude lower than that of P-2H-WS2 and the Raman intensity enhancements are â¼10-37 times higher. In contrast to the charge transfer (CT) mechanism governed by the Fermi level in metallic-phase 2M-WS2, 2H-WS2 obtained by phase transition exhibits accelerated CT facilitated by the bandgap reduction and reorganization resulting from the abundance of vacancies. This study introduces an interesting perspective and potential avenue for enhancing SERS through metal-to-semiconductor phase transitions in 2D TMDCs materials.
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Global climate change has significantly impacted the production of various crops, particularly long-term fruit-bearing plants such as citrus. This study analyzed the fruit quality of 12 citrus orchards (Citrus Sinensis L.Osbeck cv. Bingtang) in a subtropical region in Yunnan, China from 2014 to 2022. The results indicated that high rainfall (>220 mm) and low cumulative temperature (<3150 °C) promoted increases in titratable acidity (>1.8 %) in young fruits. As the fruits further expanded (with a horizontal diameter increasing from 50 to 65 mm), excessive rainfall (300-400 mm), lower cumulative temperature (<2400 °C), and a reduced diurnal temperature range (<10 °C) hindered decreases in titratable acidity. Conversely, low rainfall (<220 mm), high cumulative temperature (>3150 °C), and a high diurnal temperature range (>14 °C) promoted the accumulation of soluble solids in young fruits (9 %) at 120 days after flowering (DAF). Furthermore, low rainfall (<100 mm) favored the accumulation of soluble solids (1.5 %) during fruit expansion (195-225DAF). To quantify the relationship between fruit acidity and climate variables at 120 DAF, we developed a regression model, which was further validated by actual measurements and accurately predicted fruit acidity in 2023. Our findings have the potential to assist citrus growers in optimizing cultivation techniques for the production of high-quality citrus under increasingly variable climatic conditions.
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Citrus sinensis , Citrus , Mudança Climática , China , Temperatura Baixa , FrutasRESUMO
Sarcopenia, a leading cause for global disability and mortality, is an age-related muscular disorder, characterized by accelerated muscle mass loss and functional decline. It is known that caloric restriction (CR), ketogenic diet or endurance exercise lessen sarcopenia and elevate circulating ß-hydroxybutyrate (ß-HB) levels. Whether the elevated ß-HB is essential to the reversal of sarcopenia, however, remains unclear. Here we show in both Caenorhabditis elegans and mouse models that an increase of ß-HB reverse myofiber atrophy and improves motor functions at advanced ages. ß-HB-induced histone lysine ß-hydroxybutyrylation (Kbhb) is indispensable for the reversal of sarcopenia. Histone Kbhb enhances transcription of genes associated with mitochondrial pathways, including oxidative phosphorylation, ATP metabolic process and aerobic respiration. This ultimately leads to improve mitochondrial integrity and enhance mitochondrial respiration. The histone Kbhb are validated in mouse model with CR. Thus, we demonstrate that ß-HB induces histone Kbhb, increases mitochondrial function, and reverses sarcopenia.
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Electrocatalytic nitrate (NO3-) reduction reaction (eNO3-RR) to ammonia under ambient conditions is deemed a sustainable route for wastewater treatment and a promising alternative to the Haber-Bosch process. However, there is still a lack of efficient electrocatalysts to achieve high NH3 production performance at wastewater-relevant low NO3- concentrations. Herein, we report a Pd74Ru26 bimetallic nanocrystal (NC) electrocatalyst capable of exhibiting an average NH3 FE of â¼100% over a wide potential window from 0.1 to -0.3 V (vs. reversible hydrogen electrode, RHE) at a low NO3- concentration of 32.3 mM. The average NH3 yield rate at -0.3 V can reach 16.20 mg h-1 cm-2. Meanwhile, Pd74Ru26 also demonstrates excellent electrocatalytic stability for over 110 h. Experimental investigations and density functional theory (DFT) calculations suggest that the electronic structure modulation between Pd and Ru favors the optimization of NO3- transport with respect to single components. Along the *NO3 reduction pathway, the synergy between Pd and Ru can also lower the energy barrier of the rate-determining steps (RDSs) on Ru and Pd, which are the protonation of *NO2 and *NO, respectively. Finally, this unique alloying design achieves a high-level dynamic equilibrium of adsorption and coupling between *H and various nitrogen intermediates during eNO3-RR.