Dual-Ligand Red Perovskite Ink for Electrohydrodynamic Printing Color Conversion Arrays over 2540 dpi in Near-Eye Micro-LED Display.

The lack of stability of red perovskite nanocrystals (PeNCs) remains the main problem that restricts their patterning application. In this work, the dual-ligand passivation strategy was introduced to stabilize PeNCs and inhibit their halogen ion migration during high-voltage electrohydrodynamic (EHD) inkjet printing. The as-printed red arrays exhibit the highest emisson intensity and least blue shift compared with samples with other passivation strategies under a high electric field during EHD inkjet printing. Combining with blue and green PeNC inks, single-color and tricolor color conversion layer arrays were successfully printed, with minimum pixel size of 5 µm and the highest spatial resolution of 2540 dpi. The color coordinate of CsPbBrI2 NCs arrays are located close to the red point, with a color gumat of 97.28% of Rec. 2020 standard. All of these show great potential in the application of color conversion layers in a near-eye micro-LED display.

Nonlinear metasurface engineering with disordered gold nanorods on ITO: a cost-effective approach to broadband response, polarization-independence, and weak nonlinear index dispersion.

The strong coupling of epsilon-near-zero materials with nanoantennas has demonstrated enhanced nonlinear optical responses, yet practical challenges persist. Here, we propose an alternative: an ultrathin metasurface featuring broadband response with a weakly dispersive nonlinear index, achieved through a simple implementation. Our metasurface, comprising a disordered gold nanorod array on indium tin oxide, exhibits polarization-independent behavior and a large average nonlinear refractive index of 5 cm2/GW across a broad wavelength range (1000-1300 nm). Enhanced performance is attributed to the weak coupling between gold nanorods and indium tin oxide, offering a cost-effective method for nonlinear optical metasurfaces and a flexible design in nanophotonic applications.

Active control of an electromagnetically induced transparency analogue in a coupled dual bound states in the continuum system integrated with graphene.

Electronically induced transparency (EIT) is a coherent optical phenomenon that induces interference within atoms, allowing certain specific frequencies of light to pass through atomic media without being absorbed. However, EIT systems face challenges related to narrow transparency windows and precise control of slow light. We propose an interference structure based on a coupled dual bound states in the continuum (BIC) system to emulate the EIT-like effect. By integrating quasi-BIC (bright mode) with BIC (dark mode), our design successfully achieves an EIT-like effect in a narrow bright mode with a full width at half maximum (FWHM) of less than 1 nm. Its notable features are the bright mode's wide tunability achieved through structural parameter adjustment and a significant group delay of up to 14.43 ps. Additionally, integrating graphene into the BIC structure introduced a form of active tunability akin to the EIT-like effect. We numerically calculate the coupling structure, and its intrinsic mechanism is analyzed. Analysis based on coupled-mode theory confirms that this active modulation primarily stems from changes in the BIC structure's loss. Due to its special frequency selectivity and insensitivity to the polarization of the light source, this narrow-band EIT-like structure is particularly suitable for high-precision optical sensing and spectroscopy. The significant group delay of this structure enhances the interaction between light and matter, improving the accuracy and efficiency of optical signal control and data transmission, opening up new avenues for slow light applications and making significant progress in the development of active tunable optical switches and modulators.

Tailoring electrode surface charge to achieve discrimination and quantification of chemically similar small molecules with electrochemical aptamers.

Electrochemical biosensors based on structure-switching aptamers offer many advantages because they can operate directly in complex samples and offer the potential to integrate with miniaturized electronics. Unfortunately, these biosensors often suffer from cross-reactivity problems when measuring a target in samples containing other chemically similar molecules, such as precursors or metabolites. While some progress has been made in selecting highly specific aptamers, the discovery of these reagents remains slow and costly. In this work, we demonstrate a novel strategy to distinguish molecules with miniscule difference in chemical composition (such as a single hydroxyl group) - with cross reactive aptamer probes - by tuning the charge state of the surface on which the aptamer probes are immobilized. As an exemplar, we show that our strategy can distinguish between DOX and many structurally similar analytes, including its primary metabolite doxorubicinol (DOXol). We then demonstrate the ability to accurately quantify mixtures of these two molecules based on their differential response to sensors with different surface-charge properties. We believe this methodology is general and can be extended to a broad range of applications.

The Hinge Region of the Israeli Acute Paralysis Virus Internal Ribosome Entry Site Directs Ribosomal Positioning, Translational Activity, and Virus Infection.

All viruses must usurp host ribosomes for viral protein synthesis. Dicistroviruses utilize an intergenic region internal ribosome entry site (IGR IRES) to directly recruit ribosomes and mediate translation initiation from a non-AUG start codon. The IGR IRES adopts a three-pseudoknot structure that comprises a ribosome binding domain of pseudoknot II and III (PKII and PKIII), and a tRNA-like anticodon domain (PKI) connected via a short, one to three nucleotide hinge region. Recent cryo-EM structural analysis of the dicistrovirus Taura syndrome virus (TSV) IGR IRES bound to the ribosome suggests that the hinge region may facilitate translocation of the IRES from the ribosomal A to P site. In this study, we provide mechanistic and functional insights into the role of the hinge region in IGR IRES translation. Using the honeybee dicistrovirus, Israeli acute paralysis virus (IAPV), as a model, we demonstrate that mutations of the hinge region resulted in decreased IRES-dependent translation in vitro. Toeprinting primer extension analysis of mutant IRESs bound to purified ribosomes and in rabbit reticulocyte lysates showed defects in the initial ribosome positioning on the IRES. Finally, using a hybrid dicistrovirus clone, mutations in the hinge region of the IAPV IRES resulted in decreased viral yield. Our work reveals an unexpected role of the hinge region of the dicistrovirus IGR IRES coordinating the two independently folded domains of the IRES to properly position the ribosome to start translation. IMPORTANCE Viruses must use the host cell machinery to direct viral protein expression for productive infection. One such mechanism is an internal ribosome entry site that can directly recruit host cell machinery. In this study, we have identified a novel sequence in an IRES that provides insight into the mechanism of viral gene expression. Specifically, this novel sequence promotes viral IRES activity by directly guiding the host cell machinery to start gene expression at a specific site.

Reversibly reconfigurable GSST metasurface for broadband beam steering and achromatic focusing in the long-wave infrared.

Active optical metasurfaces promise compact, lightweight, and energy-efficient optical systems with unprecedented performance. Chalcogenide phase-change material Ge2Sb2Se4Te1 (GSST) has shown tremendous advantages in the design of mid-infrared active metasurfaces. However, most of the GSST-based active metasurfaces can only work efficiently within a narrow frequency range. Furthermore, their design flexibility and reversible switching capability are severely restricted by the melting of GSST during re-amorphization. Here, we propose broadband, reversibly tunable, GSST-based transmissive metasurfaces operating in the long-wave infrared spectrum, where the GSST micro-rods are cladded by refractory materials. To accurately evaluate the performance of the proposed metasurfaces, two figures of merits are defined: FOMΦ for the evaluation of wavefront matching, and FOMop for the assessment of the overall performance incorporating both wavefront modulation efficiency and switching contrast ratio. For the proof of concept, two meta-devices are numerically presented: a multifunctional deflector that offers continuous beam steering and long-wave pass filtering simultaneously, and a large-area (1 cm × 1 cm) broadband (11-14 µm) varifocal metalens with the ability of achromatic imaging (12.5-13.5 µm). In particular, the metalens features high FOMop values over 16 dB in the achromatic band, with the average focusing efficiency approximating 70% (60%) in amorphous (crystalline) state and a spectral switching contrast ratio surpassing 25 dB. Our design scheme provides an additional degree of freedom for dynamic modulation and offers a novel approach for achieving high-efficiency mid-infrared compact optical devices.

Robust design of mid-infrared GaSb-based single-mode laser diode fabricated by standard photolithography with socketed ridge-waveguide modulation.

In this paper, we put up a robust design of a stable single-mode-operated GaSb-based laser diode emitting around 1950nm. This novel design structure with socketed ridge-waveguide enables a simple fabrication and batch production of mid-infrared laser diodes on account of the mere usage of standard photolithography. By introducing micron-level index perturbations distributed along the ridge waveguide, the threshold gains of different FP modes are modulated. Four geometrical parameters of the perturbations are systematically optimized by analyzing the reflection spectrum to get a robust single-mode characteristic. Based on the optimized geometrical parameters, 1-mm long uncoated lasers are carried out and exhibit a stable single longitudinal mode from 10 °C to 40 °C with a maximum output power of more than 10 mW. Thus, we prove the feasibility of the standard photolithography to manufacture the monolithic single-mode infrared laser source without regrowth process or nanoscale lithography.

A tunable wide-angle narrowband perfect absorber based on an optical cavity containing hyperbolic metamaterials.

We demonstrate that wide-angle narrowband absorption can be achieved from a microcavity where a hyperbolic metamaterial and a dielectric layer are sandwiched between two metal reflectors. As the incident angle changes, the phase-shift variation in the hyperbolic metamaterial can compensate that in the dielectric layer and, consequently, result in the angle-insensitive Fabry-Perot resonance in the proposed cavity. Silicon, indium tin oxide (ITO), and gold layers are used to construct the microcavity to produce a narrow absorption band in the near-infrared region. Our device exhibits good absorption stability over a wide angle range of incidence from 0° to 70°. Moreover, the absorption wavelength can be tuned by changing the thickness of the resonator. The presented absorber may find potential applications in the design of narrowband thermophotovoltaic emitters, sensitive detectors, filters, etc.

Boosting optical nonlinearity in epsilon-near-zero trilayer coatings.

Materials with large optical nonlinearity are highly desired for various applications such as all-optical signal processing and storage. Recently, indium tin oxide (ITO) has been found to possess strong optical nonlinearity in the spectral region where its permittivity vanishes. Here, we demonstrate that ITO/Ag/ITO trilayer coatings, deposited by magnetron sputtering with high-temperature heat treatment, can significantly enhance the nonlinear response in their effective epsilon-near-zero (ENZ) regions. The obtained results show that the carrier concentrations of our trilayer samples can reach 7.25 × 1021 cm-3, and the ENZ region can shift to the spectrum close to the visible range. In the ENZ spectral region, the ITO/Ag/ITO samples exhibit enhanced nonlinear refractive indices as large as 2.397 × 10-15 m2 W-1, over 27 times larger than that of an individual ITO layer. Such a nonlinear optical response is well described using a two-temperature model. Our findings provide a new paradigm for developing nonlinear optical devices for applications requiring low power.

Molecular Mechanism and Agricultural Application of the NifA-NifL System for Nitrogen Fixation.

Nitrogen-fixing bacteria execute biological nitrogen fixation through nitrogenase, converting inert dinitrogen (N2) in the atmosphere into bioavailable nitrogen. Elaborating the molecular mechanisms of orderly and efficient biological nitrogen fixation and applying them to agricultural production can alleviate the "nitrogen problem". Azotobacter vinelandii is a well-established model bacterium for studying nitrogen fixation, utilizing nitrogenase encoded by the nif gene cluster to fix nitrogen. In Azotobacter vinelandii, the NifA-NifL system fine-tunes the nif gene cluster transcription by sensing the redox signals and energy status, then modulating nitrogen fixation. In this manuscript, we investigate the transcriptional regulation mechanism of the nif gene in autogenous nitrogen-fixing bacteria. We discuss how autogenous nitrogen fixation can better be integrated into agriculture, providing preliminary comprehensive data for the study of autogenous nitrogen-fixing regulation.

Orthogonal Trichromatic Upconversion with High Color Purity in Core-Shell Nanoparticles for a Full-Color Display.

Materials with tunable emission colors has attracted increasing interest in both fundamental research and applications. As a key member of light-emitting materials family, lanthanide doped upconversion nanoparticles (UCNPs) have been intensively demonstrated to emit light in any color upon near-infrared excitation. However, realizing the trichromatic emission in UCNPs with a fixed composition remains a great challenge. Here, without excitation pulsed modulation and three different near-infrared pumping, we report an experimental design to fine-control emission in the full color gamut from core-shell-structured UCNPs by manipulating the energy migration through dual-channel pump scheme. We also demonstrate their potential application in full-color display. These findings may benefit the future development of convenient and versatile optical methos for multicolor tuning and open up the possibility of constructing full-color volumetric display systems with high spatiotemporal resolution.

Dual-directional group delays during optical topological transitions in black phosphorus-based asymmetric hyperbolic metamaterials.

We theoretically study the optical properties of TM waves when their magnetic field direction is perpendicular to the armchair and zigzag optical axes of black phosphorus, respectively. It is found that hyperbolic dispersion and elliptic dispersion coexist in periodically arranged black phosphorus multilayers. Interestingly, by tilting the symmetric multilayers to be asymmetric, the elliptical part of the original two dispersions disappears as the wavelength increases. As such only the hyperbolic dispersion remains, showing an optical topological transition. In the region of the topological transition, a large transmitted group delay (3ps) and a reflected group delay (0.2ps) of the TM waves occurs simultaneously. The corresponding group velocities are slowed down to approximately c/1000 and c/100 (c is the speed of light in a vacuum), respectively. This dual-directional group delays significantly increase the wave-matter interaction so that nonreciprocal perfect absorptions can be realized in the mid-infrared band. Such asymmetrical black phosphorus hyperbolic metamaterials can be applied to the directional, tunable, and nonreciprocal perfect absorbers and also to devices based on strong wave-matter interactions.

Topologically protected plasmon mode with ultrastrong field localization in a graphene-based metasurface.

Graphene plasmons, the electromagnetic waves coupled to charge excitations in a graphene sheet, have attracted great interest because of their intriguing properties, such as electrical tunability, long plasmon lifetime, and high degree of spatial confinement. They may enable the manufacture of novel optical devices with extremely high speed, low driving voltage, low power consumption and compact sizes. In this paper, we propose a graphene-based metasurface which can support a topologically protected graphene plasmon mode with the ability of ultrastrong field localization. We show that such a plasmonic metasurface, constructed by depositing a graphene sheet on a periodic silicon substrate, would exhibit different bandgap topological characteristics as the filling factor of the periodic substrate changes. By setting suitable Fermi levels of graphene at two different areas of the metasurface, topological interface plasmon modes can be excited, resulting in over 8 orders of magnitude enhancement of the plasmon intensity. The topologically protected plasmon mode is robust against the perturbation of the structural parameters, and its frequency can be tuned by adjusting the gate-voltage on the graphene sheet. This highly integrated platform could provide a pathway for low-power and actively controllable nonlinear optics.

High spectral purity GaSb-based blazed grating external cavity laser with tunable single-mode operation around 1940nm.

In this article, we present a tunable GaSb-based blazed grating external cavity laser (BG-ECL) with high spectral purity and high output power single-mode operation around 1940nm. The drastic increase in spectral selectivity and optical power results from the employment of a single-transverse-mode operating narrow ridge waveguide laser diode with an optimized AR coating on the front facet. The stable fundamental spatial mode output beam from the laser diode enables efficient collimation and high coupling efficiency with the blazed grating, leading to stronger wavelength-selective feedback. The AR coating with proper low reflectivity on the straight waveguide effectively suppresses the internal cavity mode lasing without causing extra optical loss. As a result, the BG-ECL device exhibits excellent comprehensive performance with a side mode suppression ratio (SMSR) over 50 dB with optical power exceeding 30 mW within a 70 nm tuning range. A maximum SMSR of 56.26 dB with 35.12 mW output power was observed in continuous-wave operation. By increasing the working temperature of the diode laser, the tuning range can be further extended to over 100 nm without noticeable degradation in spectral and output power performance.

Visible to near-infrared nearly perfect absorption from alternate silica and chromium layers deposited by magnetron sputtering.

We present a novel, to the best of our knowledge, broadband and angle-insensitive nearly perfect absorber design composed of alternate silica and chromium layers. We show that by depositing a chromium nanofilm on a chromium substrate with a silica spacer, the absorption will significantly enhance from the visible to near-infrared. Then, another silica film is placed on the top of the layered structure as an antireflection coating, resulting in the broadband near-perfect absorption. We fabricate the proposed absorber by magnetron sputtering. The measured results show that our device has an average absorption over 97% in a wide range of wavelengths ranging from 350 to 1170 nm, and its absorption performance exhibits a good angular tolerance up to 50°. The presented absorber design offers a good prospect for large-scale and low-cost manufacturing of absorption-based optoelectronic devices.

In situ label-free and sensitive detection assay for cell apoptosis via polyadenosine-coralyne fluorescence enhancement strategy.

Cell apoptosis detection is vital for biological analysis and clinical application; some detection assays are already commercially available. However, it is still far from perfect and needs further improvement for less cost, time-consuming and operation demanding. TUNEL, a high market share cell apoptosis assay, depends on adulteration fluorescent labelling dUTP by terminal deoxynucleotidyl transferase(TdT) which randomly adds deoxyribonucleoside triphosphates (dNTPs) at the 3'-OH terminal of ssDNA with a template-free manner. Based on our previous work, we adopted a label-free strategy to reduce the cost and operation maintenance of TUNEL and developed a facile, rapid, convenient and in-situ assay for cell apoptosis.

Experimental and theoretical studies on glucose conversion in ethanol solution to 5-ethoxymethylfurfural and ethyl levulinate catalyzed by a Brønsted acid.

The fundamental understanding of glucose conversion to 5-ethoxymethylfurfural (EMF) and ethyl levulinate (EL) (value-added chemicals from biomass) in ethanol solution catalyzed by a Brønsted acid is limited at present. Consequently, here, the reaction pathways and mechanism of glucose conversion to EMF and EL catalyzed by a Brønsted acid were studied, using an experimental method and quantum chemical calculations at the B3LYP/6-31G(D) and B2PLYPD3/Def2TZVP level under a polarized continuum model (PCM-SMD). By further verification through GC/MS tests, the mechanism and reaction pathways of glucose conversion in ethanol solution catalyzed by a Brønsted acid were revealed, showing that glucose is catalyzed by proton and ethanol, and ethanol plays a bridging role in the process of proton transfer. There are three main reaction pathways: through glucose and ethyl glucoside (G/EG), through fructose, 5-hydroxymethylfurfural (HMF), levulinic acid (LA), and EL (G/F/H/L/EL), and through fructose, HMF, EMF, and EL (G/F/H/E/EL). The G/F/H/E/EL pathway with an energy barrier of 20.8 kcal mol-1 is considered as the thermodynamic and kinetics primary way, in which the reaction rate of this is highly related to the proton transfer in the isomerization of glucose to fructose. The intermediate HMF was formed from O5 via a ring-opening reaction and by the dehydration of fructose, and was further converted to the main product of EMF by etherification or by LA through hydrolysis. EMF and LA are both unstable, and can partially be transformed to EL. This study is beneficial for the insights aiding the understanding of the process and products controlling biomass conversion in ethanol solution.

A sub-1V, microwatt power-consumption iontronic pressure sensor based on organic electrochemical transistors.

Wearable and implantable pressure sensors are in great demand for personalized health monitoring. Pressure sensors with low operation voltage and low power-consumption are desired for energy-saving devices. Organic iontronic devices, such as organic electrochemical transistors (OECTs), have demonstrated great potential for low power-consumption bioelectronic sensing applications. The ability to conduct both electrons and ions, in addition to their low-operation voltage has enabled the widespread use of OECTs in different biosensing fields. However, despite these merits, OECTs have not been demonstrated for pressure sensing applications. This is because most OECTs are gated with aqueous electrolyte, which fails to respond to external pressure. Here, a low power-consumption iontronic pressure sensor is presented based on an OECT, in which an ionic hydrogel is used as a solid gating medium. The resultant iontronic device operated at voltages less than 1 V, with a power-consumption between ~ 101-103 µW, while maintaining a tunable sensitivity between 1 ~ 10 kPa-1. This work places OECTs on the frontline for developing low power-consumption iontronic pressure sensors and for biosensing applications.

CBD: A Deep-Learning-Based Scheme for Encrypted Traffic Classification with a General Pre-Training Method.

With the rapid increase in encrypted traffic in the network environment and the increasing proportion of encrypted traffic, the study of encrypted traffic classification has become increasingly important as a part of traffic analysis. At present, in a closed environment, the classification of encrypted traffic has been fully studied, but these classification models are often only for labeled data and difficult to apply in real environments. To solve these problems, we propose a transferable model called CBD with generalization abilities for encrypted traffic classification in real environments. The overall structure of CBD can be generally described as a of one-dimension CNN and the encoder of Transformer. The model can be pre-trained with unlabeled data to understand the basic characteristics of encrypted traffic data, and be transferred to other datasets to complete the classification of encrypted traffic from the packet level and the flow level. The performance of the proposed model was evaluated on a public dataset. The results showed that the performance of the CBD model was better than the baseline methods, and the pre-training method can improve the classification ability of the model.

Library research support services in China's universities of traditional medicine: Understanding user requirements.

In this article, Ms Yihang Chen with her supervisor, Prof Lihong Zhou, reports on her MA in Library Science study aimed to identify user requirements of library research support services (RSS) at the universities of Traditional Chinese Medicine (TCM) in China. This study adopted an inductive qualitative approach, employed as a case study and 14 TCM researchers and academic librarians using semi-structured interviews. The research findings point to 28 RSS requirements in five main themes: mastering, planning, project, publication and electronic preservation stages. Although this research is situated in China, it has implications for libraries worldwide in supporting research into holistic and indigenous medicine. F.J.