Selective Detection of Dynamics-Complete Set of Correlations via Quantum Channels.

Correlations of fluctuations are essential to understanding many-body systems and key information for advancing quantum technologies. To fully describe the dynamics of a physical system, all time-ordered correlations (TOCs), i.e., the dynamics-complete set of correlations are needed. The current measurement techniques can only access a limited set of TOCs, and there has been no systematic and feasible solution for extracting the dynamic-complete set of correlations hitherto. Here we propose a platform-universal protocol to selectively detect arbitrary types of TOCs via quantum channels. In our method, the quantum channels are synthesized with various controls, and engineer the evolution of a sensor-target system along a specific path that corresponds to a desired correlation. Using nuclear magnetic resonance, we experimentally demonstrate this protocol by detecting a specific type of fourth-order TOC that has never been accessed previously. We also show that the knowledge of the TOCs can be used to significantly improve the precision of quantum optimal control. Our method provides a new toolbox for characterizing the quantum many-body states and quantum noise, and hence for advancing the fields of quantum sensing and quantum computing.

Integration of land ecological consolidation and ecosystem product value realization: A case from the Yangtze riverside industrial park in Changzhou, China.

Traditional industries and industrialization have led to widespread environmental pollution and ecosystem degradation in major river basins globally. Strategies centered on ecological restoration and ecological economy are emerging as essential tools for effective environmental governance. This study aims to investigate how a multifaceted framework for land ecological consolidation, with various developmental goals, can effectively support ecological restoration and sustainability. Through quantitative analysis and in-depth interviews, we investigated the case of Yangtze riverside chemical industrial park in Changzhou. This park pursues ecological and economic sustainability through chemical industry transformation, ecological restoration and protection, ecological management, and ecological industry development. The results show that this practice established a multi-objective action framework rooted in urban renewal, land consolidation, ecological restoration, industrial transformation, and rural revitalization. Through multiplanning integration, integrated implementation and full-cycle profit distribution, the aim of ecological protection has been initially achieved, offering a crucial guarantee for sustainable development. A total of 96.47 ha ecological space expanded, which can generate ecological product worth CNY 7.283 billion, alongside a net economic benefit of CNY 978 million over three decades. The top-down ecological responsibilities, coupled with local developmental demands, have stimulated collaborations within a bottom-up endogenous network comprising government, enterprises, and residents.

Mitigation role of physical exercise participation in the relationship between blood cadmium and sleep disturbance: a cross-sectional study.

The neurotoxicity of heavy metals received increasingly attention in recent years. Sleeping is regulated and coordinated by nervous system, however, the health hazard of heavy metal like cadmium (Cd) exposure on sleep health remained unknown. Rescue strategies like physical exercise (PE) has emerged to mitigate such influence. An epidemiological design with cross-sectional data from National Health and Nutrition Examination Survey 2007-2010 was applied. The relationship between three blood heavy metals [cadmium (Cd), lead (Pb), mercury (Hg)] and sleep disturbance was analyzed. A total of 8,751 participants were finally included in and the weighted participants were 330,239,463. Weighted quantile sum (WQS) regression indicated that mixed blood metals were positively related to risk of sleep disturbance and the mixture effect of exposure to heavy metals was mainly attributable to Cd (89.1%). Weighted logistic regression showed a significant positive association between the highest quartile of blood Cd and sleep disturbance [(OR (95% CI)): 1.191 (1.014,1.400), p = 0.036] in the fully adjusted model, while no association was found under Pb and Hg exposure. In the association between Q3 and Q4 level of blood Cd and sleep disturbance, moderate-to-vigorous physical exercise group had lower risks than none and low exercise group. In the restricted cubic spline model, it was also verified that higher PE participation was associated with the lowest incidence of sleep disturbance with the increment in Cd concentration. Our study suggested that both policy makers and the public should minimize heavy metal exposure. Moreover, conducting moderate to vigorous physical exercise is a protecting factor to mitigate Cd's influence on sleep health.

Muscle quality index is associated with trouble sleeping: a cross-sectional population based study.

BACKGROUND: Trouble sleeping is one of the major health issues nowadays. Current evidence on the correlation between muscle quality and trouble sleeping is limited. METHODS: A cross-sectional study design was applied and participants aged from 18 to 60 years in the National Health and Nutrition Examination Survey (NHANES) 2011-2014 was used for analysis. Muscle quality index (MQI) was quantitatively calculated as handgrip strength (HGS, kg) sum/ arm and appendicular skeletal muscle mass (ASM, kg) by using the sum of the non-dominant hand and dominant hand. Sleeping data was obtained by interviews and self-reported by individuals. The main analyses utilized weighted multivariable logistic regression models according to the complex multi-stage sampling design of NHANES. Restricted cubic spline model was applied to explore the non-linear relationship between MQI and trouble sleeping. Moreover, subgroup analyses concerning sociodemographic and lifestyle factors were conducted in this study. RESULTS: 5143 participants were finally included in. In the fully adjusted model, an increased level of MQI was significantly associated with a lower odds ratio of trouble sleeping, with OR = 0.765, 95% CI: (0.652,0.896), p = 0.011. Restricted cubic spline showed a non-linear association between MQI and trouble sleeping. However, it seemed that the prevalence of trouble sleeping decreased with increasing MQI until it reached 2.362, after which the odds ratio of trouble sleeping reached a plateau. Subgroup analyses further confirmed that the negative association between the MQI and trouble sleeping was consistent and robust across groups. CONCLUSION: Overall, this study revealed that MQI can be used as a reliable predictor in odds ratio of trouble sleeping. Maintaining a certain level of muscle mass would be beneficial to sleep health. However, this was a cross-sectional study, and causal inference between MQI and trouble sleeping was worthy of further exploration.

Using Functionalized Graphene Oxide as Carrier for Immobilization of Glutaryl-7-Aminocephalosporanic Acid Acylase.

Graphene oxide has been widely used in biological applications because of good biocompatibility. In the present work, graphene oxide was synthesized successfully and was employed to immobilize glutaryl-7-aminocephalosporanic acid acylase (GLA). The immobilization conditions like pH, temperature, immobilization time, and enzyme/carrier ratio were investigated. Under the optimal immobilization conditions, the immobilization yield and efficiency were 86% and 52%, respectively. The characterization of the immobilized GLA was performed and compared with the free enzyme. The results indicated that the stability of the immobilized GLA was 1.7-folds than that of the free enzyme, and the kinetic parameters were also calculated. All these results show the potential industrial applications of the immobilized GLA in the production of 7-aminocephalosporinal acid (7-ACA).

Surfactant-free microemulsions of 1-butyl-3-methylimidazolium hexafluorophosphate, propylamine nitrate, and water.

Generally, surfactants (or amphiphiles) are believed to be necessary components of microemulsions. However, it has been demonstrated that, in the absence of traditional surfactants, microemulsions can also form from a ternary system of two immiscible fluids (i.e., oil and water phases) and an amphi-solvent, but the current understanding of such surfactant-free microemulsions (SFMEs) is very limited. Herein, we report an SFME consisting of the hydrophobic ionic liquid (IL) 1-butyl-3-methylimidazolium hexafluorophosphate (bmimPF6), the protic IL propylamine nitrate (PAN), and water, in which bmimPF6 and PAN are used as the oil phase and the amphi-solvent, respectively. The microstructures and structural transitions of the SFME were investigated using cyclic voltammetry, fluorescence spectroscopy, and ultraviolet-visible spectroscopy. The SFME exhibited water-in-bmimPF6 (W/IL), bicontinuous (BC), and bmimPF6-in-water (IL/W) microstructures, depending on the composition of the ternary system, similar to the case of traditional surfactant-based microemulsions (SBMEs). The three kinds of microstructures were confirmed by cryogenic transmission electron microscopy (cryo-TEM) observations. To the best of our knowledge, this is the first report on SFMEs composed of two ILs as components, especially where one is used as the amphi-solvent.

[Clinical significance of serum amylase and lipase in patients with acute paraquat poisoning].

OBJECTIVE: To investigate the changes in serum amylase (AMY) and lipase (LPS) and their clinical significance in patients with acute paraquat poisoning (APP). METHODS: The clinical data of 62 APP. patients who were admitted to Guangzhou 12th People's Hospital in 2014 were retrospectively analyzed. With clinical death being regarded as the end point of observation, the 62 patients were divided into survival group (n=32) and death group (n=30). The fasting venous blood of the patients on the 1st, 3rd, and 7th day after admission were collected, and the AMY and LPS levels were determined; the obtained data were compared between the two groups and analyzed statistically. RESULTS: The AMY and LPS levels of the survival group on the 1st, 3rd, and 7th day after admission were significantly lower than those of the death group (P<0.05); the AMY and LPS levels of the death group on the 3rd day were significantly higher than those on the 1st day after admission (P<0.05); the survival group demonstrated no significant changes in AMY and LPS levels (P>0.05). CONCLUSION: Changes in AMY and LPS levels in APP patients are reliable indicators for the determination of poisoning severity and prognosis.

[Dynamic observation of clinical course in patients with subacute 1, 2-dichloroethane poisoning].

OBJECTIVE: To observe the clinical characteristics and regular patterns of subacute 1, 2-dichloroethane poisoning patients for providing evidences to it's diagnosis, treatment and prognosis. METHODS: 51 cases of subacute 1, 2-dichloroethane poisoning analyzed. They were divided into 3 groups according to their main clinical manifestation: group A mainly with intracranial hypertension (n = 25), group B with limbs tremor (n = 18), group C with mental and behavior disorder (n = 8). All cases' clinical symptoms, cranial computer tomography, cerebrospinal pressure (Group A) were observed, the durations of the onset, deterioration, improvement, recovery and whole course of the disease were compared between groups and in each group. RESULTS: In all of 51 cases, only the differences between the deterioration duration of cranial CT and symptom was significantly (t = 2.555, P<0.05), which indicate the deterioration of symptom was earlier than radiological change. The symptom deterioration of group C was the fastest than group A and group B (P<0.00). As to the change of symptom duration, group B's improvement, recovery and whole course was the longest comparing with group A and group C (P<0.05). As to the change of cranial CT duration, group B's recovery duration was the shortest and group A's recovery duration was the longest (P<0.01); group B's whole course was also the shortest and group A's whole course was the longest (P<0.05). The clinical course of symptoms, cranial computer tomography, cerebrospinal pressure (Group A) was compared in each group, in group A, the duration of improvement and whole course of the cranial CT and cerebrospinal pressure change was longer than that of the symptom change (P<0.01), this indicated that group A has longer asymptomatic intracranial hypertension and their cranial radiography recover slowly. In group B, their symptoms (3.94 ± 4.31 days) deteriorated is earlier than cranial CT changes (P<0.05), the recovery (92.39 ± 55.04 days) and whole course of symptom was longer than cranial CT change (all P<0.01). In group C, symptom deterioration was earlier than CT deterioration (P< 0.05). CONCLUSION: The clinical characteristic of subacute 1, 2- dichloroethane poisoning is central nervous system damage, it differs according to the different stage of course, the regions and severity of pathology lesions.

Remaining Useful Life Prediction of Rolling Bearings Based on ECA-CAE and Autoformer.

In response to the need for multiple complete bearing degradation datasets in traditional deep learning networks to predict the impact on individual bearings, a novel deep learning-based rolling bearing remaining life prediction method is proposed in the absence of fully degraded bearng data. This method involves processing the raw vibration data through Channel-wise Attention Encoder (CAE) from the Encoder-Channel Attention (ECA), extracting features related to mutual correlation and relevance, selecting the desired characteristics, and incorporating the selected features into the constructed Autoformer-based time prediction model to forecast the degradation trend of bearings' remaining time. The feature extraction method proposed in this approach outperforms CAE and multilayer perceptual-Attention Encoder in terms of feature extraction capabilities, resulting in reductions of 0.0059 and 0.0402 in mean square error, respectively. Additionally, the indirect prediction approach for the degradation trend of the target bearing demonstrates higher accuracy compared to Informer and Transformer models, with mean square error reductions of 0.3352 and 0.1174, respectively. This suggests that the combined deep learning model proposed in this paper for predicting rolling bearing life may be a more effective life prediction method deserving further research and application.

Biological Control of Root Rot of Strawberry by Bacillus amyloliquefaciens Strains CMS5 and CMR12.

Strawberry root rot caused by Fusarium solani is one of the main diseases of strawberries and significantly impacts the yield and quality of strawberry fruit. Biological control is becoming an alternative method for the control of plant diseases to replace or decrease the application of traditional chemical fungicides. To obtain antagonistic bacteria with a high biocontrol effect on strawberry root rot, over 72 rhizosphere bacteria were isolated from the strawberry rhizosphere soil and screened for their antifungal activity against F. solani by dual culture assay. Among them, strains CMS5 and CMR12 showed the strongest inhibitory activity against F. solani (inhibition rate 57.78% and 65.93%, respectively) and exhibited broad-spectrum antifungal activity. According to the phylogenetic tree based on 16S rDNA and gyrB genes, CMS5 and CMR12 were identified as Bacillus amyloliquefaciens. Lipopeptide genes involved in surfactin, iturin, and fengycin biosynthesis were detected in the DNA genomes of CMS5 and CMR12 by PCR amplification. The genes related to the three major lipopeptide metabolites existed in the DNA genome of strains CMS5 and CMR12, and the lipopeptides could inhibit the mycelial growth of F. solani and resulted in distorted hyphae. The inhibitory rates of lipopeptides of CMS5 and CMR12 on the spore germination of F. solani were 61.00% and 42.67%, respectively. The plant-growth-promoting (PGP) traits in vitro screening showed that CMS5 and CMR12 have the ability to fix nitrogen and secreted indoleacetic acid (IAA). In the potting test, the control efficiency of CMS5, CMR12 and CMS5+CMR12 against strawberry root rot were 65.3%, 67.94% and 88.00%, respectively. Furthermore, CMS5 and CMR12 enhanced the resistance of strawberry to F. solani by increasing the activities of defense enzymes MDA, CAT and SOD. Moreover, CMS5 and CMR12 significantly promoted the growth of strawberry seedlings such as root length, seedling length and seedling fresh weight. This study revealed that B. amyloliquefaciens CMS5 and CMR12 have high potential to be used as biocontrol agents to control strawberry root rot.

Inverted U-shaped relationship between sleep duration and phenotypic age in US adults: a population-based study.

Sleep is a modifiable behavior that can be targeted in interventions aimed at promoting healthy aging. This study aims to (i) identify the sleep duration trend in US adults; (ii) investigate the relationship between sleep duration and phenotypic age; and (iii) explore the role of exercise in this relationship. Phenotypic age as a novel index was calculated according to biomarkers collected from US adults based on the National Health and Nutrition Examination Survey (NHANES). Sleep information was self-reported by participants and discerned through individual interviews. The principal analytical method employed was weighted multivariable linear regression modeling, which accommodated for the complex multi-stage sampling design. The potential non-linear relationship was explored using a restricted cubic spline (RCS) model. Furthermore, subgroup analyses evaluated the potential effects of sociodemographic and lifestyle factors on the primary study outcomes. A total of 13,569 participants were finally included in, thereby resulting in a weighted population of 78,880,615. An examination of the temporal trends in sleep duration revealed a declining proportion of individuals with insufficient and markedly deficient sleep time since the 2015-2016 cycle. Taken normal sleep group as a reference, participants with extreme short sleep [ß (95% CI) 0.582 (0.018, 1.146), p = 0.044] and long sleep [ß (95% CI) 0.694 (0.186, 1.203), p = 0.010] were both positively associated with phenotypic age using the fully adjusted model. According to the dose-response relationship between sleep duration and phenotypic age, long sleep duration can benefit from regular exercise activity, whereas short sleep duration with more exercise tended to have higher phenotypic age. There is an inverted U-shaped relationship between short and long sleep durations and phenotypic age. This study represents an important step forward in our understanding of the complex relationship between sleep and healthy aging. By shedding light on this topic and providing practical exercise recommendations for promoting healthy sleep habits, researchers can help individuals live longer, healthier, and more fulfilling lives.

Mediation Role of Recreational Physical Activity in the Relationship between the Dietary Intake of Live Microbes and the Systemic Immune-Inflammation Index: A Real-World Cross-Sectional Study.

The main topic of this research is the relationship between dietary intake of live microbe-containing (LMC) foods, recreational physical activity (RPA), and the systemic immune-inflammation index (SII). This study presented a cohort of 26,254 individuals in the National Health and Nutrition Examination Survey (NHANES), representing an estimated weighted population of 193,637,615 in the United States. Weighted multivariable linear regression models were used in consideration of the multi-stage sampling design. Results: The study found that medium-LMC foods were negatively associated with the SII [ß (95% CI): -4.807 (-7.752, -1.862), p = 0.002], indicating that their intake was correlated with lower levels of the SII. However, no significant associations were found with low- or high-LMC foods. The study also explored the relationship between RPA and the SII, finding that more time spent in RPA was negatively associated with the SII [ß (95% CI): -0.022 (-0.034, -0.011), p < 0.001]. A mediation analysis was conducted to investigate the role of RPA in the relationship between medium-LMC food intake and the SII. The analysis revealed that RPA had a notable indirect effect, contributing to 6.7% of the overall change in the SII. Overall, this study suggests that medium-LMC food intake and RPA may have beneficial effects on systemic immune inflammation.

Efficacy and Safety Assessment of Intrathoracic Perfusion Chemotherapy Combined with immunological factor Interleukin-2 in the Treatment of Advanced Non-Small Cell Lung Cancer: A Retrospective Cohort Study.

Objective: This study evaluated the efficacy and safety of the gemcitabine and oxaliplatin intrathoracic perfusion chemotherapy (IPCGOR) regimen combined with interleukin-2 (IL-2) for advanced non-small cell lung cancer (NSCLC). Methods: We conducted a retrospective analysis of 460 advanced NSCLC patients from the Yunnan Province Early Cancer Diagnosis and Treatment Project (June 2020-October 2022), assessing the IPCGOR and IL-2 combination. Outcomes were measured based on RECIST 1.1 criteria, focusing on objective response rate (ORR), disease control rate (DCR), median progression-free survival (mPFS), median overall survival (MOS), and treatment safety. Results: The treatment demonstrated an ORR of 67.4%, a DCR of 97.4%, an mPFS of 8.5 months, and an MOS of 12.5 months. 14 patients underwent successful surgery post-treatment. Common adverse reactions were manageable, with no treatment-related deaths reported. Conclusion: The IPCGOR combined with IL-2 regimen shows promising efficacy and a tolerable safety profile for advanced NSCLC. These findings suggest its potential as a reference for treating advanced NSCLC. However, the study's retrospective nature and single-center design pose limitations. Future research should focus on prospective studies, randomized controlled trials, and long-term outcome assessments, particularly in diverse patient subgroups, to further validate and refine the clinical application of this regimen.

Reactive aging of films of secondary organic material studied by infrared spectroscopy.

The reactive aging of films of secondary organic material (SOM) to ozone, irradiation, and water was studied by attenuated total reflectance infrared spectroscopy (ATR-IR). The films were prepared by deposition onto the ATR elements of particles produced by reaction of isoprene with hydroxyl radicals and of α-pinene with ozone in the Harvard Environmental Chamber (HEC). The infrared spectra showed that the isoprene-derived film had strong hydroxyl absorptions whereas the α-pinene-derived film had strong carbonyl absorptions. The organic films were exposed to dry and humid flows of ozone, as well as to ultraviolet irradiation, to mimic reactive aging processes that can occur in the troposphere. Both the isoprene- and α-pinene-derived films were nonreactive with respect to ozone exposure, for both dry and humid conditions, indicating that the secondary organic material consisted mostly of saturated organic species. Both films, however, were susceptible to aging by ultraviolet radiation possibly due to the presence of organic hydroperoxides, and all functional groups other than carbonyls decreased upon irradiation. In regard to hygroscopicity, as a benchmark the ratio x(W_CO) for oxalic acid of the intensity of the water-bending peak to that of carbonyl absorption (arising from carboxylic acids) was recorded from 20% to 80% relative humidity (RH). This quantity was then also measured for the isoprene- and α-pinene-derived organic films. The result of (x(W_CO))(isoprene) > (x(W_CO))(benchmark) across the range of studied RH values shows that species other than carboxylic acids contributed significantly to the hygroscopicity of the isoprene-derived film. The spectra were consistent with alcohols and hydroperoxides as the hygroscopic components. By comparison, the result of (x(W_CO))(pinene) ≈ (x(W_CO))(benchmark) indicates a dominance of carboxylic acids with respect to the hygroscopicity of this film.

[Progress in the application of conducting polymer in glucose biosensor].

Conducting polymers have stable long-chain structure and good electrical conductivity. They have been used in various types of biosensors because of their excellent characteristics of the immobilization and electrical signal transmission. In recent years, researchers mainly study on improving its micro-nano structures and its signal conductivity to enhance its effect on the enzyme immobilization and signal conductive properties. This paper reviews firstly the application of conducting polymer on enzyme-immobilized glucose biosensor and the new technologies and methods in this field. This paper also points out the future application of conducting polymers in enzyme immobilization and biosensor preparation areas.

Identification of status quo and association rules for chronic comorbidity among Chinese middle-aged and older adults rural residents.

Background: Chronic comorbidity has become a major challenge in chronic disease prevention and control. This issue is particularly pronounced in rural areas of developing countries, where the prevalence of chronic disease comorbidity is high, especially among middle-aged and older adults populations. However, the health status of middle-aged and older adults individuals in rural areas of China has received inadequate attention. Therefore, it is crucial to investigate the correlation among chronic diseases to establish a reference basis for adjusting health policies aimed at promoting the prevention and management of chronic diseases among middle-aged and older adults individuals. Methods: This study selected 2,262 middle-aged and older adults residents aged 50 years or older in Shangang Village, Jiangsu Province, China, as the study population. To analyze the chronic comorbidity of middle-aged and older adults residents with different characteristics, we used the χ2 test with SPSS statistical software. Data analysis was conducted using the Apriori algorithm of Python software, set to mine the strong association rules of positive correlation between chronic disease comorbidities of middle-aged and older adults residents. Results: The prevalence of chronic comorbidity was 56.6%. The chronic disease comorbidity group with the highest prevalence rate was the lumbar osteopenia + hypertension group. There were significant differences in the prevalence of chronic disease comorbidity among middle-aged and older adults residents in terms of gender, BMI, and chronic disease management. The Apriori algorithm was used to screen 15 association rules for the whole population, 11 for genders, and 15 for age groups. According to the order of support, the most common association rules of comorbidity of three chronic diseases were: {lumbar osteopenia} → {hypertension} (support: 29.22%, confidence: 58.44%), {dyslipidemia} → {hypertension} (support: 19.14%, confidence: 65.91%) and {fatty liver} → {hypertension} (support: 17.82%, confidence: 64.17%). Conclusion: The prevalence of chronic comorbidity among middle-aged and older adults rural residents in China is relatively high. We identified many association rules among chronic diseases, dyslipidemia is mostly the antecedent, and hypertension is primarily the result. In particular, the majority of comorbidity aggregation patterns consisted of hypertension and dyslipidemia. By implementing scientifically-proven prevention and control strategies, the development of healthy aging can be promoted.

Accelerometer-measured physical activity patterns are associated with phenotypic age: Isotemporal substitution effects.

Prolonged sitting appears to accelerate aging, while optimal physical activity patterns have been found to delay the process. It is an emerging topic, and no conclusions have been reached regarding the relationship between physical activity patterns and biomarkers-measured aging. Hence, the aim of this study was to investigate the association between sensor-based objectively measured physical activity and phenotypic age using a nationwide population from the National Health and Nutrition Examination Survey (NHANES) in the United States. Weighted linear regression models were performed to evaluate the association between sedentary behavior, light-intensity physical activity (LPA), moderate-to-vigorous physical activity (MVPA) and phenotypic age. A total of 6439 eligible participants were included and the weighted respondents were 49,964,300. Results showed that prolonged sitting was positively associated with phenotypic age in the fully adjusted model [ß (95% CI): 0.009(0.007,0.011), p < 0.001], while increasing volume of LPA and MVPA was associated with younger phenotypic age using the fully adjusted model [ß (95% CI): -0.010(-0.013,-0.006), p < 0.001; -0.062(-0.075,-0.048), p < 0.001]. By utilizing the Isotemporal Substitution Model, it was found that replacing 30 min of sedentary behavior with 30 min of LPA or MVPA per day was associated with estimated 0.4 or 1.9 years of phenotypic age reduction. According to the study's findings, maintaining a certain level of physical activity could delay the process of aging and intensity matters.