Fault Diagnosis of the Rolling Bearing by a Multi-Task Deep Learning Method Based on a Classifier Generative Adversarial Network.

Accurate fault diagnosis is essential for the safe operation of rotating machinery. Recently, traditional deep learning-based fault diagnosis have achieved promising results. However, most of these methods focus only on supervised learning and tend to use small convolution kernels non-effectively to extract features that are not controllable and have poor interpretability. To this end, this study proposes an innovative semi-supervised learning method for bearing fault diagnosis. Firstly, multi-scale dilated convolution squeeze-and-excitation residual blocks are designed to exact local and global features. Secondly, a classifier generative adversarial network is employed to achieve multi-task learning. Both unsupervised and supervised learning are performed simultaneously to improve the generalization ability. Finally, supervised learning is applied to fine-tune the final model, which can extract multi-scale features and be further improved by implicit data augmentation. Experiments on two datasets were carried out, and the results verified the superiority of the proposed method.

Occurrence of antibiotics in wastewater: Potential ecological risk and removal through anaerobic-aerobic systems.

Antibiotics are intensively used to improve public health, prevent diseases and enhance productivity in animal farms. Contrarily, when released, the antibiotics laden wastewater produced from pharmaceutical industries and their application sources poses a potential ecological risk to the environment. This study provides a discussion on the occurrence of various antibiotics in wastewater and their potential ecological risk in the environment. Further, a critical review of anaerobic-aerobic processes based on three major systems (such as constructed wetland, high-rate bioreactor, and integrated treatment technologies) applied for antibiotics removal from wastewater is performed. The review also explores microbial dynamics responsible for antibiotic biodegradation in anaerobic-aerobic systems and its economic feasibility at wider-scale applications. The operational problems and prospective modifications are discussed to define key future research directions. The appropriate selection of treatment processes, sources control, understanding of antibiotic fate, and adopting precise monitoring strategies could eliminate the potential ecological risks of antibiotics. Integrated bio-electrochemical systems exhibit antibiotics removal ≥95% by dominant Geobacter sp. at short HRT ∼4-10 h. Major process factors like organic loading rate, hydraulic loading rate (HRT), and solid retention time significantly affect the system performance. This review will be beneficial to the researchers by providing in-depth understanding of antibiotic pollution and its abatement via anaerobic-aerobic processes to develop sustainable wastewater treatment technology in the future.

Anaerobic-aerobic treatment of wastewater and leachate: A review of process integration, system design, performance and associated energy revenue.

Hybrid anaerobic-aerobic biological systems are an environmentally sustainable way of recovering bioenergy during the treatment of high-strength wastewaters and landfill leachate. This study provides a critical review of three major categories of anaerobic-aerobic processes such as conventional wetland, high-rate and integrated bioreactor systems applied for treatment of wastewaters and leachate. A comparative assessment of treatment mechanisms, critical operating parameters, bioreactor configurations, process control strategies, efficacies, and microbial dynamics of anaerobic-aerobic systems is provided. The review also explores the influence of wastewater composition on treatment performance, ammonium nitrogen removal efficacy, impact of mixing leachate, energy consumption, coupled bioenergy production and economic aspects of anaerobic-aerobic systems. Furthermore, the operational challenges, prospective modifications, and key future research directions are discussed. This review will provide in-depth understanding to develop sustainable engineering applications of anaerobic-aerobic processes for effective co-treatment of wastewaters and leachate.

Efficacy of air purifier therapy for patients with allergic asthma.

OBJECTIVES: This study aimed to evaluate the efficacy of air purifier therapy for patients with allergic asthma. METHODS: Thirty-eight subjects were categorized under two groups namely treatment group and control group. All subjects were under 18 years of age and they had been clinically diagnosed with allergic asthma. The treatment group used high efficiency particulate air (HEPA) purifiers for six consecutive months, and the control group did not use the air filters. Particulate matter (PM) data and dust samples (from bedding and a static point) were collected from the subjects' bedrooms before they started using the air purifiers and each month thereafter. Simultaneously, the subjects were asked to complete a questionnaire for the Asthma Control Test (ACT) or Childhood Asthma Control Test (C-ACT). Fractional exhaled nitric oxide (FENO) tests were performed at the start and end of the study. The concentrations of Der p1 and Der f1 were measured in the dust samples. RESULTS: (1) After utilizing the air purifier, the concentrations of house dust mite (HDM) allergens (Der p1+ Der f1) in the dust samples decreased. In addition, the PMindoor/outdoor values significantly decreased. (2) The ACT and C-ACT scores in the treatment group maintained a steady significant upward trend. (3) At the end of the study, the FENO levels in both groups were lower, although the differences were not significant. CONCLUSIONS: It is witnessed that HEPA air purifiers can decrease indoor HDM allergen and PM levels and improve the quality of life for allergic asthma patients.

A review on plant-microbial interactions, functions, mechanisms and emerging trends in bioretention system to improve multi-contaminated stormwater treatment.

Management and treatment of multi-polluted stormwater in bioretention system have gained significant attraction recently. Besides nutrients, recent source appointment studies found elevated levels of Potentially toxic metal(loid)s (PTMs) and contaminants of emerging concern (CECs) in stormwater that highlighted many limitations in conventional media adsorption-based pollutant removal bioretention strategies. The substantial new studies include biological treatment approaches to strengthen pollutants degradation and adsorption capacity of bioretention. The knowledge on characteristics of plants and their corresponding mechanisms in various functions, e.g., rainwater interception, retention, infiltration, media clogging prevention, evapotranspiration and phytoremediation, is scattered. The microorganisms' role in facilitating vegetation and media, plant-microorganism interactions and relative performance over different functions in bioretention is still unreviewed. To uncover the underneath, it was summarised plant and microbial studies and their functionality in hydrogeochemical cycles in the bioretention system in this review, contributing to finding their interconnections and developing a more efficient bioretention system. Additionally, source characteristics of stormwater and fate of associated pollutants in the environment, the potential of genetical engineered plants, algae and fungi in bioretention system as well as performance assessment of plants and microorganisms in non-bioretention studies to propose the possible solution of un-addressed problems in bioretention system have been put forward in this review. The present review can be used as an imperative reference to enlighten the advantages of adopting multidisciplinary approaches for the environment sustainability and pollution control.

Activation of Paraventricular Melatonin Receptor 2 Mediates Melatonin-Conferred Cardioprotection Against Myocardial Ischemia/Reperfusion Injury.

Previous studies have shown that melatonin (Mel) can effectively ameliorate myocardial ischemia/reperfusion (MI/R) injury, but the mechanism is yet to be fully elucidated. Mel receptors are expressed in the paraventricular nucleus (PVN), which is also involved in regulating cardiac sympathetic nerve activity. The aim of this study was to examine whether Mel receptors in the PVN are involved in the protective effects of Mel against MI/R injury. The results of quantitative polymerase chain reaction, western blot, and immunofluorescence assays indicated that Mel receptor 2 (MT2) expression in the PVN was upregulated after MI/R. Intraperitoneal administration of Mel significantly improved post-MI/R cardiac function and reduced the infarct size, whereas shRNA silencing of MT2 in the PVN partially blocked this effect. Intraperitoneal administration of Mel reduced sympathetic nerve overexcitation caused by MI/R, whereas shRNA silencing of MT2 in the PVN partially diminished this effect. Furthermore, enzyme-linked immunosorbent assay and western blot results indicated that intraperitoneal administration of Mel lowered the levels of inflammatory cytokines in the PVN after MI/R injury, whereas the application of sh-MT2 in the PVN reduced this effect of Mel. Mel significantly reduced the levels of NF-κB after astrocyte oxygen and glucose deprivation/reoxygenation injury, and this effect was offset when MT2 was silenced. The above experimental results suggest that MT2 in the PVN partially mediated the protective effects of Mel against MI/R injury, and its underlying mechanisms may be related to postactivation amelioration of PVN inflammation and reduction of cardiac sympathetic nerve overexcitation.

A modified surgical technique of shortening renal ischemia time in left renal cancer patients with Mayo level II-IV tumor thrombus.

BACKGROUND: To explore the safety and effectiveness of a modified surgical technique which could shorten the time of renal ischemia in left renal cancer and Mayo level II to IV inferior vena cava (IVC) tumor thrombus. METHOD: We retrospectively analyzed the clinical data of 14 cases with left renal cell carcinoma (RCC) and Mayo level II to IV IVC tumor thrombus from February 2015 to July 2019. Preoperative imaging showed that there was no obvious sign of tumor thrombus invading the blood vessel wall. During the surgery, after the right renal artery, the right renal vein and the distal end of IVC were blocked, the balloon catheter was used and the tumor thrombus was removed completely from the IVC. The incision of IVC was closed by Satinsky clamp to make IVC partially blocked. Then the right renal artery and right renal vein were released. The incision of IVC was sutured continuously. At last, the Satinsky clamp and the blocking band at the distal end of the IVC were released. RESULT: There were 8 cases (57.1%) of Mayo level II, 3 cases (21.4%) of Mayo level III and 3 cases (21.4%) of Mayo level IV. The operation was successfully completed in all 14 patients. There were 2 cases (14.3%) operated by complete laparoscopic approach, 8 cases (57.1%) by open approach, and 4 patients (28.6%) by laparoscopic conversion to open approach. The occlusion time of right renal artery and vein (renal ischemia time) was 3 to 15 min, with an average of (6.8 ± 3.2) minutes. The mean time of IVC occlusion was (19.4 ± 4.9) min. Preoperative creatinine was 66 to 130 µmol/L, with an average of (96.6 ± 21.2) µmol/L. One week after operation, serum creatinine was 64 to 632 µmol/L, with an average of (132.4 ± 144.9) µmol/L. Among the 14 cases, 5 (42.9%) had early postoperative complications. Besides one of the 14 patients died in perioperative period, the median follow-up of other 13 cases was 10 months (range: 4-29 months). The 5 (35.7%) of the 14 cases were died of disease. CONCLUSION: This modified procedure was relatively safe and effective in shortening the time of renal ischemia in left RCC patients with Mayo II to IV IVC tumor thrombus.

Application of standardized platelet-rich plasma in elderly patients with complex wounds.

In recent years, autologous platelet-rich plasma (PRP) derivatives have been used widely in the regeneration and repair of tissue, but a standard definition and preparation method for PRP are lacking. We developed a standardized method using platelet indices as quality-control indicators for PRP preparation. Twenty-one elderly patients (9 males, 12 females) with complex wounds were treated with standardized platelet-rich plasma (S-PRP). The platelet count in PRP after the second centrifugation was 1,069-1,436 × 109 /L. We adjusted the platelet concentration in PRP after a second centrifugation to 1,000 × 109 /L according to a formula using platelet-poor plasma (PPP). The standardized preparation method that we developed gave S-PRP with a relatively uniform platelet concentration. The wounds of 21 patients showed accelerated healing after S-PRP treatment, and there were no obvious side effects during treatment. These data suggest that our preparation method of S-PRP, using platelet indices as quality-control indicators with platelet count of 1,000 × 109 /L could be used for the treatment of complex wounds in the elderly. The preparation method of S-PRP proposed in the present study may be a simple and effective method of PRP quality control.

Occurrence, speciation and fate of mercury in the sewage sludge of China.

Municipal sewage has been identified to be an important source of mercury (Hg) to the environment. However, as the major sink of sewage-borne Hg, sewage sludge (SS) remains unresolved in terms of the occurrence status of Hg species. We presented here, a nation-wide survey on the speciation of Hg in SS of China. Total Hg (THg) and methylmercury (MeHg) were detected in all SS samples, within ranges of 0.4-12.4 mg/kg and 0.1-27.0 µg/kg, respectively. Sludge-borne Hg mainly occurred in the mercury sulfide and organo-chelated phases, with only tiny portions occurring as soluble Hg. The mass loadings of sludge-borne THg and MeHg in China for year 2016 were estimated to be 12.2 metric tons and 19.9 kg, respectively. Landfill was the most important sink of sludge-borne Hg, followed by incineration, land application, and building materials.

Phytoextraction of initial cutting of Salix matsudana for Cd and Cu.

Salix species are widely used as vegetation filters because of their flourishing root system and fast growth rate. However, studies have yet to determine whether the root system functions in vegetable filters with mixed heavy metal (HM) pollution or whether initial cutting participates in the phytoextraction of HMs. This study aims to determine the function of the root system and initial cutting as vegetation filters in the absorption and accumulation of Cd and Cu. Thick (>1 cm in diameter) and fine (<1 cm in diameter) initial cuttings of Salix matsudana were planted in a nutrient solution with single and mixed (Cd + Cu) treatments. The roots of several initial cuttings were removed daily to eradicate rhizofiltration. Results revealed that the existence of the root system altered distribution and interaction of Cd and Cu in plant organs and enhanced tolerance and phytoextraction capacity of plants. The initial cuttings could also absorb and accumulate HMs in the early growth stages of willow without roots. Cu inhibited the plant absorption and accumulation of Cd and promoted Cd transport to shoots. Cd inhibited the Cu absorption of the root system. Our study provided essential data regarding woody species as vegetation filters of HM pollution.

Investigating the effect of age on platelet ultrastructure using transmission electron microscopy.

In the present study, the age- and sex-related differences in platelet ultrastructure were investigated using transmission electron microscopy (TEM). A total of 15 healthy volunteers were grouped according to age, with 5 people in each of the following groups: young group (25-45 years), middle-aged group (46-65 years), and old-aged group (> 65 years). In the TEM micrographs, the internal components, specifically the α-granules, dense granules, and lysosomal granules, of 20 platelets were counted for each group. Two-way analysis of variance of age and sex variance was used to compare the results. The ultrastructure of the platelets in the old-aged group was observed to be quite different from those of the young and middle-aged groups. Specifically, with ageing, the platelet membrane becomes more irregular in shape and non-smooth, and multiple platelet membrane ruptures are observed. Furthermore, the pseudopodia and protuberances become more numerous and slender, and the number of α-granules is significantly reduced. These morphological changes indicate that ageing may affect the function of platelets, which in turn affects the efficacy of platelet concentrates. Thus, the effects of age should be considered when using platelet concentrates prepared from elderly autologous blood.

Counterfactual entanglement swapping enables high-efficiency entanglement distribution.

We propose an alternative entanglement swapping scheme based on the principle of the counterfactual quantum communication, which demonstrates nonlocal entanglement swapping can be achieved by the operations of a third party. During the whole process, it is not needed to transmit any physical particles among the participants. Furthermore, all the entangled particles are not destroyed in the counterfactual entanglement swapping process, which means we can obtain two pairs of nonlocal entanglement at the same time, thus achieve high-efficiency entanglement distribution. The numerical analysis about the performance of the presented scheme shows that this counterfactual protocol can be implemented with high success probability and fidelity in the ideal asymptotic limit. The scheme may be meaningful for large-scale quantum communication network and quantum repeater.

Co-Expression Analysis of Blood Cell Genome Expression to Preliminary Investigation of Regulatory Mechanisms in Uremia.

BACKGROUND Uremia involves a series of clinical manifestations and is a common syndrome that occurs in nearly all end-stage kidney diseases. However, the exact genetic and/or molecular mechanisms that underlie uremia remain poorly understood. MATERIAL AND METHODS In this case-control study, we analyzed whole-genome microarray of 75 uremia patients and 20 healthy controls to investigate changes in gene expression and cellular mechanisms relevant to uremia. Gene co-expression network analysis was performed to construct co-expression networks using differentially expressed genes (DEGs) in uremia. We then determined hub models of co-expressed gene networks by MCODE, and we used miRNA enrichment analysis to detect key miRNAs in each hub module. RESULTS We found nine co-expressed hub modules implicated in uremia. These modules were enriched in specific biological functions, including "proteolysis", "membrane-enclosed lumen", and "apoptosis". Finally, miRNA enrichment analysis to detect key miRNAs in each hub module found 15 miRNAs that were specifically targeted to uremia-related hub modules. Of these, miRNA-21-3p and miRNA-210-3p have been identified in other studies as being important for uremia. CONCLUSIONS In summary, our study connected biological functions, genes, and miRNAs that underpin the network modules that can be used to elucidate the molecular mechanisms involved in uremia.

The Helicobacter heilmannii hofE and hofF Genes are Essential for Colonization of the Gastric Mucosa and Play a Role in IL-1ß-Induced Gastric MUC13 Expression.

BACKGROUND: Helicobacter heilmannii is a zoonotic bacterium associated with gastric disease in humans. We recently showed that H. heilmannii binds to human gastric mucins and epithelial cells and highlighted a potential role for the murine Muc13 mucin in gastric Helicobacter colonization. The aims of this study were to investigate the role of the H. heilmannii hof gene locus encoding HofH/F/E/G/C/D in adhesion to the gastric mucosa and induction of increased gastric Muc13 expression. METHODS: Bacterial hof gene and host gene expression experiments, Helicobacter binding assays and experimental infection studies in mice were performed. H. pylori and its ΔhofF mutant were included for comparison. RESULTS: Helicobacter heilmannii strains lacking HofE or HofF showed a clear decrease in binding to gastric mucins and epithelial cells as well as a lower gastric colonization level in the stomach of Balb/c mice at 4 and 9 weeks post-infection compared to the H. heilmannii wildtype strain. Interestingly, H. heilmannii ΔhofE and ΔhofF and H. pylori ΔhofF did not induce an increased expression of MUC13 in human gastric epithelial cells and of Muc13 in the stomach of mice. Finally, we demonstrated that IL-1ß is induced in the stomach as a response to Helicobacter colonization which on its turn is involved in the expression of MUC13/Muc13 in the gastric epithelium. CONCLUSION: These novel results in Helicobacter research identified H. heilmannii HofE and HofF as adhesins and suggest an important role of H. heilmannii HofE and HofF and H. pylori HofF in IL-1ß-induced gastric MUC13/Muc13 expression.

Counterfactual entanglement distribution without transmitting any particles.

To date, all schemes for entanglement distribution needed to send entangled particles or a separable mediating particle among distant participants. Here, we propose a counterfactual protocol for entanglement distribution against the traditional forms, that is, two distant particles can be entangled with no physical particles travel between the two remote participants. We also present an alternative scheme for realizing the counterfactual photonic entangled state distribution using Michelson-type interferometer and self-assembled GaAs/InAs quantum dot embedded in a optical microcavity. The numerical analysis about the effect of experimental imperfections on the performance of the scheme shows that the entanglement distribution may be implementable with high fidelity.

Size of the semicircular canals measured by multidetector computed tomography in different age groups.

PURPOSE: The purpose of the study was to obtain reference values for the sizes of the semicircular canals (SCCs) on multidetector computed tomographic (CT) images in different age groups. METHODS: Computed tomographic images of the temporal bone of 210 patients, a total of 420 ears without inner ear pathology, have been evaluated. These patients were divided into 4 groups by age: young children (<7 years), older children and adolescents (8-17 years), adults (18-59 years), and the elderly patients (>60 years). The inner diameter, maximum height, and width of the SCCs were measured. RESULTS: There was no significant difference in the size of SCC among the 4 age groups. The inner diameter measurements of the anterior SCC, lateral SCC, and posterior SCC were 0.101 ± 0.016, 0.135 ± 0.033, and 0.124 ± 0.021 cm, respectively. The height measurements of the anterior SCC, lateral SCC, and posterior SCC were 0.535 ± 0.086, 0.349 ± 0.090, and 0.490 ± 0.109 cm, respectively. The width measurements of the anterior SCC, lateral SCC, and posterior SCC were 0.567 ± 0.080, 0.302 ± 0.082, and 0.472 ± 0.099 cm, respectively. CONCLUSIONS: The size of SCCs remains constant from children to the elderly people, unlike the other human organs. The reference values provided by multidetector CT can serve as an aid for the interpretation of CT images.

The thin-layer drying characteristics of sewage sludge by the appropriate foaming pretreatment.

As dewatered sludge is highly viscous and sticky, the combination of foaming pretreatment and drying process seems to be an alternative method to improve the drying performance of dewatered sludge. In this study, CaO addition followed by mechanical whipping was employed for foaming the dewatered sludge. It was found that the foams were stable and the diameters of bubbles mainly ranged from 0.1 to 0.3 mm. The drying experiments were carried out in a drying oven in the convective mode. The results indicated that foamed sludge at 0.70 g/cm(3) had the best drying performance at each level of temperature, which could save 35-45% drying time to reach 20% moisture content compared with the non-foamed sludge. The drying rate of foamed sludge at 0.70 g/cm(3) was improved with the increasing of drying temperature. The impact of sample thickness on drying rate was not obvious when the sample thickness increased from 2 to 8 mm. Different mathematical models were used for the simulation of foamed sludge drying curves. The Wang and Singh model represented the drying characteristics better than other models with coefficient of determination values over 0.99.

Does the implementation of economic policies connected to climate change depend on monetary policy mandates and financial stability governance structures?

The objective of the proposed research study is to examine how the economic policy mandates and governance frameworks of central banks affect the implementation of climate-related economic measures. Empirical evidence supports a positive correlation between the adoption of climate-related economic policies and a broader mandate for monetary policy. The existing body of research contradicts the idea that an enhanced framework for governing economic stability will result in higher implementation of financial measures related to climate change. The study, which focuses on China from 2015 to 2023, concludes that enhanced economic stability governance, founded on less integrated arrangements, leads to more successful implementation of climate-related financial measures. For other criteria such as central bank independence, the existence of a democratic government, and membership in the Sustainable Banking Network, a positive and statistically significant influence is seen across all specifications. Physical risks associated with climate change, such as heat waves, droughts, floods, and storms, as well as transition risks represented by variables like per-person CO2 emissions, policies aimed at mitigating climate change, and the financial capacity to carry out climate adaptation plans, must also manifest. Even after accounting for a new dependent variable and several alternative model parameters, the findings hold up well. We employ a fixed-effects panel regression approach to control for unobserved heterogeneity and isolate the impact of time-varying variables on renewable energy production. This methodology ensures robust and consistent estimates, providing clear insights into how monetary policy adjustments influence renewable energy investments.

Bacterial bioburden of duodenoscope elevator mechanism in different reprocessing stages.

Over the past decade, infections linked to duodenoscopes have become a significant concern, primarily due to the intricate design of the elevator mechanism. Currently, there is limited evidence regarding the bacterial contamination level of the elevator mechanism after clinical use and throughout its various reprocessing stages. This study utilized the swab culture technique to examine the bacterial contamination on the duodenoscope elevator mechanism after clinical use and after 3 reprocessing stages at a Center of tertiary hospital. Our findings revealed severe bacterial contamination after clinical usage, emphasizing that the effectiveness of manual cleaning greatly influences the subsequent high-level disinfection quality.