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1.
J Community Health ; 41(1): 57-69, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26205070

RESUMO

Variability of heat stress illness (HSI) by urbanicity and climate region has rarely been considered in previous HSI studies. We investigated temporal and geographic trends in HSI emergency department (ED) visits in CDC Environmental Public Health Tracking Network (Tracking) states for 2005-2010. We obtained county-level HSI ED visit data for 14 Tracking states. We used the National Center for Health Statistics Urban-Rural Classification Scheme to categorize counties by urbanicity as (1) large central metropolitan (LCM), (2) large fringe metropolitan, (3) small-medium metropolitan, or (4) nonmetropolitan (NM). We also assigned counties to one of six US climate regions. Negative binomial regression was used to examine trends in HSI ED visits over time across all counties and by urbanicity for each climate region, adjusting for pertinent variables. During 2005-2010, there were 98,462 HSI ED visits in the 14 states. ED visits for HSI decreased 3.0% (p < 0.01) per year. Age-adjusted incidence rates of HSI ED visits increased from most urban to most rural. Overall, ED visits were significantly higher for NM areas (IRR = 1.41, p < 0.01) than for LCM areas. The same pattern was observed in all six climate regions; compared with LCM, NM areas had from 14 to 90% more ED visits for HSI. These findings of significantly increased HSI ED visit rates in more rural settings suggest a need to consider HSI ED visit variability by county urbanicity and climate region when designing and implementing local HSI preventive measures and interventions.


Assuntos
Clima , Serviço Hospitalar de Emergência/estatística & dados numéricos , Transtornos de Estresse por Calor/epidemiologia , População Rural/estatística & dados numéricos , População Urbana/estatística & dados numéricos , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Saúde Pública , Estados Unidos/epidemiologia , Adulto Jovem
2.
J Safety Res ; 88: 56-67, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38485385

RESUMO

INTRODUCTION: The Centers for Disease Control and Prevention's (CDC) National Center for Injury Prevention and Control (NCIPC) funds Injury Control Research Centers (ICRCs). These centers study injury and violence prevention through three core areas: (1) Research conducts cutting-edge, multidisciplinary research in the injury and violence prevention field; (2) Outreach translates injury and violence prevention research into action; and (3) Training educates and trains the next generation of injury and violence prevention professionals. We examined ICRC work from 2012 to 2019 to determine whether they fulfilled their goal of furthering injury and violence prevention research and practice. METHODS: We created a database of core area accomplishments reported through annual and interim progress reports. These reports track core area accomplishments by injury and violence prevention topic area, publications, partnerships, and trainings. RESULTS: From 2012 to 2019, ten ICRCs from two funding cycles received approximately $49 million. ICRCs reported 703 research, 1,432 outreach, and 660 training accomplishments. There were also 342 accomplishments contributing to a special tool or resource. These accomplishments focused on preventing traumatic brain injury, suicide, adverse childhood experiences, and transportation safety. ICRCs produced over 3,500 peer-reviewed publications. ICRCs reported over 3,600 accomplishments partnered with academic institutions, public health agencies, healthcare, and non-profit organizations. ICRCs created resources for audiences such as students, law enforcement, and policy makers. ICRCs trained 3,131 students and faculty. PRACTICAL APPLICATIONS: ICRCs are the hubs of modern research and practice in the injury and violence prevention field. They successfully bring together stakeholders from disparate disciplines, perspectives, and agencies to join forces and tackle critical public health problems. CONCLUSION: ICRCs are an integral component of NCIPC's, CDC's and the Department of Health and Human Service's missions to protect and enhance the health of Americans. Research covered NCIPC research priorities over the funding period, furthering injury and violence prevention research and working as a foundation to practice and policy. Outreach and partnerships with an array of organizations put research into action. Trainings educated the new generation of injury and violence prevention professionals.


Assuntos
Experiências Adversas da Infância , Lesões Encefálicas Traumáticas , Humanos , Estados Unidos , Violência/prevenção & controle , Saúde Pública , Centers for Disease Control and Prevention, U.S.
3.
Wilderness Environ Med ; 24(4): 422-8, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24119571

RESUMO

BACKGROUND: The Grand Canyon National Park has approximately 4 million visitors between April and September each year. During this period, outdoor activity such as hiking is potentially hazardous owing to extreme heat, limited shade, and steep, long ascents. Given the high visitation and the public health interest in the effects of extreme heat, this study calculated morbidity rates and described heat-related illness (HRI) among visitors. METHODS: We conducted a retrospective cross-sectional study from April 1 through September 30, during 2004-2009. From a review of Ranger Emergency Medical Services (EMS) incident report files, we extracted information on those that met the case definition of greater than 1 hour of outdoor heat exposure with an HRI assessment or diagnosis, HRI self-report, or signs or symptoms of HRI without another etiology noted. Visitor and temperature data were obtained from respective official sources. RESULTS: Grand Canyon EMS responded to 474 nonfatal and 6 fatal HRI cases, with the majority (84%) being US residents, 29% from Western states. Of the nonfatal cases, 51% were women, the median age was 43 years (range, 11-83 years), and 18% reported a cardiovascular condition. Clinical HRI assessments included dehydration (25%), heat exhaustion (23%), and suspected hyponatremia (19%). Almost all (90%) were hiking; 40% required helicopter evacuation. The highest HRI rates were seen in May. CONCLUSIONS: HRI remains a public health concern at the Grand Canyon. High-risk evacuations and life-threatening conditions were found. Majority were hikers, middle-aged adults, and US residents. These findings support the park's hiker HRI prevention efforts and use of park EMS data to measure HRI.


Assuntos
Serviços Médicos de Emergência , Transtornos de Estresse por Calor/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Arizona , Criança , Pré-Escolar , Estudos Transversais , Serviços Médicos de Emergência/estatística & dados numéricos , Feminino , Transtornos de Estresse por Calor/etiologia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Estações do Ano , Adulto Jovem
4.
J Conserv Dent ; 26(1): 20-25, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36908730

RESUMO

Background: Decision-making regarding whether cuspal coverage is required or not for the restoration of root canal-treated posterior teeth is still a matter of challenge for the dentist. Methodology: Four models of endodontically treated mandibular molars with mesio-occlusal (MO) cavity were designed and simulated with direct composite resin restorations. Group 1A - cavity width <½ the intercuspal distance restored without cuspal coverage, Group 1B - same as Group 1A but with cuspal coverage, Group 2A - MO cavity width >½ but <2/3rd the intercuspal distance restored without cuspal coverage, and Group 2B - same as Group 2A but with cuspal coverage. The models received occlusal load to simulate a mastication load. Static finite element analysis (FEA) was adopted for predicting the stress distribution generated in the restored tooth by the loading condition. Results: FEA of the models have shown that the variations in stress values were significant in bulk-fill material compared to enamel and other structures. Comparing the maximum and minimum principal stress values in the overall region demonstrated that 2A was safer, whereas 2B was found to be the worst case. Conclusions: The results indicate that restoration of endodontically treated mandibular molar with loss of one marginal ridge with composite resin without cuspal coverage revealed minimal internal stress values and showed the best performance overall.

5.
Chemosphere ; 340: 139890, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37619747

RESUMO

Organic dyes present in industrial wastewater are the major contributor to water pollution, which harm human health and the environment. Photocatalytic dye degradation is an effective strategy for water remediation by converting these organic dyes waste into non-harmful by-products. Therefore, in this study, Ni-doped LaFeO3 (NLFO) perovskite nanoparticles were extensively explored for photocatalytic degradation of cationic and anionic dyes and their mixture. The NLFO nanoparticles were successfully synthesized by surfactant assisted hydrothermal method under controlled Ni doping. The X-ray diffraction (XRD) and field emission scanning electron microscope (FESEM) revealed the variation in size (40-70 nm) of orthorhombic crystalline LFO nanoparticles with Ni doping and hence the size of microspheres (0.78. to 1.78 µm). The kinetic studies revealed that the LaFe0·6Ni0·4O3 performed well by providing degradation efficiency of 99.2% in 210 min, 99.1% in 100 min, and 98.4% in 70 min for Crystal Violet (CV), Congo Red (CR), and their mixture with rate constant of 0.019, 0.039, and 0.055 min-1 respectively. The radical scavenger tests indicated the synergetic contributions of O2- and •OH- active radicals in faster degradation of CV and CR dye mixture. The stepwise fragmentation of dye molecule during the photocatalytic degradation identified from the LCMS indicates the degradation of CV dye through de-alkylation and benzene ring breaking, whereas azo bond cleavage and oxidation lead to low molecular weight intermediates for CR dye, which all together helped to degrade their dye mixture (50 mg L-1 and 100 mg L-1) in significantly lesser time (70 min). Overall, the Ni-doped LFO microsphere consisting of nanoparticles acts as a superior catalyst for the more efficient and faster degradation of binary dye mixture.


Assuntos
Corantes , Óxidos , Humanos , Cinética , Água , Vermelho Congo , Cátions , Violeta Genciana
7.
Prehosp Disaster Med ; 27(4): 392-7, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22800916

RESUMO

INTRODUCTION: The Texas Department of State Health Services (DSHS) implemented an active mortality surveillance system to enumerate and characterize hurricane-related deaths during Hurricane Ike in 2008. This surveillance system used established guidelines and case definitions to categorize deaths as directly, indirectly, and possibly related to Hurricane Ike. OBJECTIVE: The objective of this study was to evaluate Texas DSHS' active mortality surveillance system using US Centers for Disease Control and Prevention's (CDC) surveillance system evaluation guidelines. METHODS: Using CDC's Updated Guidelines for Surveillance System Evaluation, the active mortality surveillance system of the Texas DSHS was evaluated. Data from the active mortality surveillance system were compared with Texas vital statistics data for the same time period to estimate the completeness of reported disaster-related deaths. RESULTS: From September 8 through October 13, 2008, medical examiners (MEs) and Justices of the Peace (JPs) in 44 affected counties reported deaths daily by using a one-page, standardized mortality form. The active mortality surveillance system identified 74 hurricane-related deaths, whereas a review of vital statistics data revealed only four deaths that were hurricane-related. The average time of reporting a death by active mortality surveillance and vital statistics was 14 days and 16 days, respectively. CONCLUSIONS: Texas's active mortality surveillance system successfully identified hurricane-related deaths. Evaluation of the active mortality surveillance system suggested that it is necessary to collect detailed and representative mortality data during a hurricane because vital statistics do not capture sufficient information to identify whether deaths are hurricane-related. The results from this evaluation will help improve active mortality surveillance during hurricanes which, in turn, will enhance preparedness and response plans and identify public health interventions to reduce future hurricane-related mortality rates.


Assuntos
Tempestades Ciclônicas/mortalidade , Vigilância da População , Acidentes/mortalidade , Causas de Morte , Feminino , Guias como Assunto , Humanos , Masculino , Saúde Pública/métodos , Texas/epidemiologia , Estatísticas Vitais , Ferimentos e Lesões/mortalidade
8.
J Conserv Dent ; 23(1): 66-70, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33223645

RESUMO

BACKGROUND: Bonding of composite with enamel and dentin gets compromised if the tooth is restored with composite immediately post bleaching. The application of antioxidants has shown to have a positive effect on it. AIM: The aim of this study was to evaluate and compare the effect of guava seed extract solutions in various concentrations on the shear bond strength (SBS) of composite resin to bleached enamel when applied for 5 min, 10 min, and 120 min. MATERIALS AND METHODS: Fifty-five maxillary incisors were procured, and labial surfaces of 50 specimens were bleached with 37.5% hydrogen peroxide. These specimens were divided into 3 experimental groups: Group 1-3 comprising 15 specimens each (n = 15), and the remaining specimens were divided into two groups: Group 4 (positive control group) and Group 5 (negative control group). Groups 1-3 were further divided into 3 subgroups according to the application period of antioxidant: subgroups A, B, and C. Specimens were stored in distilled water for 24 h. SBS testing was done using the universal testing machine. Data were tabulated and subjected to statistical analysis using a three-way analysis of variance with post hoc Tukey's test. RESULTS: Guava seed extract showed a complete reversal of the compromised bond strength, and promising results were seen with increased concentration. CONCLUSION: The use of antioxidants effectively reversed the compromised bond strength of bleached enamel, and an increase in the concentration of antioxidants reduces the duration of its application.

9.
Int J Clin Pediatr Dent ; 13(1): 35-37, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32581476

RESUMO

AIM: This study evaluates epoxy resin-based sealers after their final set, immersed in Endosolve-R or xylene for 1-2 minutes, for its easy removal mechanically after softening. MATERIALS AND METHODS: Sixty Teflon molds were grouped with 20 samples in each of the three commercially available sealers, i.e., AH 26, AH Plus, and Adseal. The sealers were put in the specific molds after their manipulation as per the instructions given in the literature by the manufacturer. They were allowed to harden for 2 weeks at 37°C in 100% humidity. Two subgroups, A-Xylene and B-Endosolv-R, of 10 samples each, were formed from 20 set specimens based on solvents to which they were immersed for 1 and 2 minutes, respectively. The data obtained was subjected to the Mauchly's test one-way ANOVA and two-way ANOVA for analysis. RESULTS: It was proved that for all the sealers immersed in solvents, there was a significant reduction in the mean Vickers hardness as the time increases. There was a significant difference in the initial hardness between the mentioned sealers with AH plus showing the highest followed by AH 26 and Adseal showing the lowest. AH Plus and Adseal sealers were softened by xylene after 2 minutes of their initial microhardness (p < 0.001); least effect was seen on AH 26. After 2 minutes, Endosolv-R softened initial microhardness of all the three sealers (p < 0.001). CONCLUSION: It was concluded that Endosolv-R was more effective in softening the epoxy-based resin sealer than xylene, after 2 minutes of exposure. HOW TO CITE THIS ARTICLE: Tyagi S, Choudhary E, Choudhary A, et al. A Comparative Evaluation of Two Commonly Used GP Solvents on Different Epoxy Resin-based Sealers: An In Vitro Study. Int J Clin Pediatr Dent 2020;13(1):35-37.

10.
J Urban Health ; 86(2): 242-9, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19096937

RESUMO

Gaps in understanding of how area-based differences in exposure to violence are associated with asthma prevalence may limit the development of effective prevention programs and the identification of risk for asthma episodes. The current investigation examines the associations between sexual violence victimization and asthma episodes among US adult women across three different metropolitan settings. The association between sexual assault victimizations and asthma attacks in the past year was examined using data from the 2005, 2006, and 2007 Behavioral Risk Factor Surveillance System surveys. Cross-sectional analyses were based on adult women with current asthma (n = 4,099). Multivariate logistic regression models were used to identify associations between four categories of sexual violence victimization and asthma episodes across three categories of metropolitan and non-metropolitan settings. Our findings show that unwanted touching, attempted unwanted intercourse, forced unwanted intercourse, and any sexual violence victimization (touching, attempted intercourse, or forced intercourse) were significantly associated with asthma episodes (OR(adj.) = 3.67, 95% CI, 1.76-7.69; OR(adj.) = 1.77, 95% CI, 1.32-2.37; OR(adj.) = 2.24, 95% CI, 1.64-3.05, and OR(adj.) = 1.93, 95% CI, 1.47-2.53, respectively). While no significant differences in the associations between asthma episodes and metropolitan status were found, a significant interaction between non-metropolitan areas and attempted sexual intercourse was identified (OR(adj) = 0.53, 95% CI, 0.29-0.96). Sexual victimization appears to be an important, but understudied, correlate of asthma morbidity among adult women in the USA, suggesting that additional research is needed to better understand the associations between sexual violence, psychological distress, and asthma.


Assuntos
Vítimas de Crime , Violência Doméstica , Delitos Sexuais , Estado Asmático/epidemiologia , Estado Asmático/etiologia , Sistema de Vigilância de Fator de Risco Comportamental , Estudos Transversais , Violência Doméstica/classificação , Feminino , Humanos , Pessoa de Meia-Idade , Delitos Sexuais/classificação , Estados Unidos/epidemiologia , População Urbana
11.
Public Health Rep ; 134(5): 552-558, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31386820

RESUMO

OBJECTIVES: Foodborne disease is a pervasive problem caused by consuming food or drink contaminated by infectious or noninfectious agents. The 55 US poison centers receive telephone calls for advice on foodborne disease cases that may be related to a foodborne disease outbreak (FBDO). Our objective was to assess whether poison center call records uploaded to the National Poison Data System (NPDS) can be used for surveillance of noninfectious FBDOs in the United States. METHODS: We matched NPDS records on noninfectious FBDO agents in the United States with records in the Foodborne Disease Outbreak Surveillance System (FDOSS) for 2000-2010. We conducted multivariable logistic regression analysis comparing NPDS matched and unmatched records to assess features of NPDS records that may indicate a confirmed noninfectious FBDO. RESULTS: During 2000-2010, FDOSS recorded 491 noninfectious FBDOs of known etiology and NPDS recorded 8773 calls for noninfectious foodborne disease exposures. Of 8773 NPDS calls, 469 (5.3%) were matched to a noninfectious FBDO reported to FDOSS. Multivariable logistic regression indicated severity of medical outcome, whether the call was made by a health care professional, and etiology as significant predictors of NPDS records matching an FDOSS noninfectious FBDO. CONCLUSIONS: NPDS may complement existing surveillance systems and response activities by providing timely information about single cases of foodborne diseases or about a known or emerging FBDO. Prioritizing NPDS records by certain call features could help guide public health departments in the types of noninfectious foodborne records that most warrant public health follow-up.


Assuntos
Doenças Transmitidas por Alimentos/epidemiologia , Notificação de Abuso , Vigilância da População , Adolescente , Adulto , Bases de Dados Factuais , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Centros de Controle de Intoxicações , Estados Unidos/epidemiologia , Adulto Jovem
12.
Clin Toxicol (Phila) ; 56(7): 646-652, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29235366

RESUMO

CONTEXT: The National Poison Data System (NPDS) is a database and surveillance system for US poison centers (PCs) call data. The Centers for Disease Control and Prevention (CDC) and American Association of Poison Control Centers (AAPCC) use NPDS to identify incidents of potential public health significance. State health departments are notified by CDC of incidents identified by NPDS to be of potential public health significance. Our objective was to describe the public health impact of CDC's notifications and the use of NPDS data for surveillance. METHODS: We described how NPDS data informed three public health responses: the Deepwater Horizon incident, national exposures to laundry detergent pods, and national exposures to e-cigarettes. Additionally, we extracted survey results of state epidemiologists regarding NPDS incident notification follow-up from 1 January 2015 to 31 December 2016 to assess current public health application of NPDS data using Epi Info 7.2 and analyzed data using SAS 9.3. We assessed whether state health departments were aware of incidents before notification, what actions were taken, and whether CDC notifications contributed to actions. DISCUSSION: NPDS data provided evidence for industry changes to improve laundry detergent pod containers safety and highlighted the need to regulate e-cigarette sale and manufacturing. NPDS data were used to improve situational awareness during the 2010 Deepwater Horizon oil spill. Of 59 health departments and PCs who responded to CDC notifications about anomalies (response rate = 49.2%), 27 (46%) reported no previous awareness of the incident, and 20 (34%) said that notifications contributed to public health action. CONCLUSIONS: Monitoring NPDS data for anomalies can identify emerging public health threats and provide evidence-based science to support public health action and policy changes.


Assuntos
Sistemas de Dados , Centros de Controle de Intoxicações , Vigilância em Saúde Pública , Saúde Pública , Detergentes/efeitos adversos , Sistemas Eletrônicos de Liberação de Nicotina , Epidemiologistas , Humanos , Poluição por Petróleo/efeitos adversos , Estados Unidos
13.
J Conserv Dent ; 21(4): 443-449, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30122829

RESUMO

BACKGROUND: The present ex vivo study explores the role of Indian medicaments in endodontic irrigation in an attempt to search for a safe alternative to sodium hypochlorite (NaOCL). AIM: To evaluate the efficacy of commercial preparations of Morinda citrifolia juice (MCJ) and Triphala juice against Enterococcus faecalis and Candida albicans. MATERIALS AND METHODS: The study was conducted on 84 permanent extracted human teeth. After decoronation and biomechanical preparation, inoculated (with E. faecalis and C. albicans) root sections were divided randomly into four experimental (MCJ, Triphala juice, 1% NaOCl, and 2% chlorhexidine [CHX]) and two control groups (preservative control and distilled water). Colony-forming units (CFUs) obtained for each group were counted at baseline (S0) and after irrigation at 1 and 3 days (S1and S2, respectively). Mean of Log CFU at S0, S1, and S2was compared for each irrigant using Friedman's two-way ANOVA. RESULTS: There was a significant decrease in microbial counts of both microbes in all groups at S1, but only CHX could demonstrate further decrease in the microbial counts of both microorganisms at S2. CONCLUSION: The overall antimicrobial effects of different irrigants were maximum for CHX, whereas MCJ and Triphala juice also showed significant reductions. The herbal irrigants hold the promise of becoming efficient irrigants and warrant further research.

14.
J Environ Pathol Toxicol Oncol ; 23(4): 279-85, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15511215

RESUMO

Fourteen textile and biological dyes, belonging to the azo, triphenylmethane, anthraquinone, heterocyclic, oxazine, and methine/polymethine groups, were degraded using the PhotoFenton treatment (PFT) and the Phanerochaete chrysosporium crude ligninase enzyme (ED) treatment. The genotoxicity of the dyes and of their degradation products were assessed with the rec-assay. We found that the genotoxicity depended on the dye and on the method of degradation. In general, PFT was better than ED in decreasing the genotoxicity. Basic dyes showed complete or maximum loss of genotoxicity, whereas the vat group was more resistant. The azo group showed varied results. Crystal Violet was the only dye whose genotoxicity increased after PFT. Our results suggest that PFT and ED are two effective treatment methods to reduce the genotoxicity of dyes in waste waters.


Assuntos
Corantes/toxicidade , Mutagênicos/toxicidade , Têxteis/toxicidade , Animais , Bacillus subtilis/efeitos dos fármacos , Bacillus subtilis/genética , Biodegradação Ambiental , Peróxido de Hidrogênio , Ferro , Masculino , Camundongos , Testes de Mutagenicidade , Oxigenases/química , Phanerochaete/metabolismo
15.
Domest Anim Endocrinol ; 27(1): 63-79, 2004 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15158535

RESUMO

We have examined the genes of the endothelin system that are targets for regulation by prostaglandin F2alpha (PGF2alpha). The effects of a luteolytic dose of PGF2alpha ) on the mRNA encoding endothelin converting enzyme-1 (ECE-1), pre-pro endothelin-1 (pp ET-1) and the ET receptors ETA, ETB, in bovine corpus luteum (CL) during the early (days 1 and 4), mid (day 10) or late (day 17) luteal phases were examined. The effect of the PGF(2alpha) treatment on ECE-1 protein, Big ET-1 and the biologically active mature ET-1 peptide were also examined. Most importantly, the direct ECE-1 activity was determined. Before day 10 of the cycle, in a PGF2alpha-independent manner, the amounts of mRNA encoding ET-1, ECE-1, ETA, and ETB were increased steadily from day 1. After day 10 of the cycle, expression of mRNA encoding pp ET-1 and ETA acquired responsiveness to exogenous PGF2alpha and both genes were up-regulated by the PGF2alpha treatment. This effect of PGF2alpha was also detected for the proteins corresponding to the mature ET-1. The enzymatic activity of ECE-1 remained unchanged throughout the lifespan of the CL in spite of the detected changes in mRNA and protein. The results suggest that the luteal endothelin system is regulated in a PGF2alpha-independent and -dependent manner. Importantly, an alteration in luteal ET-1 availability is most likely achieved by modulating the expression of mRNA encoding pp ET-1 and not by the amount or activity of ECE-1. This interpretation is supported by the observation that the activity of ECE-1 remained unchanged throughout the ovarian cycle. The combined effects of greater ET-1 availability and gene expression encoding the ETA receptor in the late luteal phase could render the CL, at this developmental stage, more sensitive or responsive to ET-1. If the luteal tissue is responsive to the available ET-1 during the early phase of the ovarian cycle, an additional role for ET-1 should be considered beyond mediating the luteolytic actions of PGF2alpha. Agents blocking the actions of ET-1 might be the best approach to interfere with the luteal ET system and test its physiological role(s) in vivo.


Assuntos
Ácido Aspártico Endopeptidases/metabolismo , Corpo Lúteo/metabolismo , Dinoprosta/fisiologia , Endotelina-1/metabolismo , Receptores de Endotelina/metabolismo , Animais , Ácido Aspártico Endopeptidases/genética , Bovinos , Corpo Lúteo/enzimologia , Endotelina-1/genética , Enzimas Conversoras de Endotelina , Ciclo Estral/fisiologia , Feminino , Regulação da Expressão Gênica/fisiologia , Metaloendopeptidases , RNA Mensageiro/análise , Receptores de Endotelina/genética , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Fatores de Tempo
16.
MMWR Surveill Summ ; 63(13): 1-10, 2014 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-25504077

RESUMO

PROBLEM/CONDITION: Heat stress illness (HSI), also known as heat-related illness, comprises mild heat edema, heat syncope, heat cramps, heat exhaustion (the most common type of HSI), and heat stroke (the most severe form). CDC's Environmental Public Health Tracking Program receives annual hospitalization discharge data from 23 states that are used to assess and monitor trends of HSI hospitalization over time. REPORTING PERIOD: May-September, 2001-2010. DESCRIPTION OF SYSTEM: The Environmental Public Health Tracking Program is a comprehensive surveillance system implemented in 25 states and one city health department. The core of the system is the Tracking Network, which collects data on environmental hazards, health effects, exposures, and population. The Tracking Network provides nationally consistent environmental and health outcome data that enable federal, state, and local public health agencies to assess trends, explore associations, and generate hypotheses using these data. For HSI surveillance, the Tracking Network uses state-based hospital discharge data. RESULTS: During 2001-2010, approximately 28,000 HSI hospitalizations occurred in 20 states participating in the Tracking Program. Data from three states were not included in this report because of missing data for ≥3 years. Two states joined the Tracking Program after the study period and also are not included in this report. The majority of HSI hospitalizations occurred among males and persons aged ≥65 years. The highest rates of hospitalizations were in the Midwest and the South. During this period, an overall 2%-5% increase in the rate of HSI hospitalizations occurred in all 20 states compared with the 2001 rate. The correlation between the average number of HSI hospitalizations and the average monthly maximum temperature/heat index was statistically significant (at p<0.0001) in all 20 states. INTERPRETATION: Consistent with previous studies, age and sex were identified as major risk factors for HSI hospitalizations. Certain Tracking states that experienced high temperatures during summer months showed an increase in rate of HSI hospitalizations over the 10-year study period. PUBLIC HEALTH ACTION: HSIs are preventable and an important focus of public health interventions at state and local health departments. Federal, state, and local public health agencies can use data on HSI hospitalizations for surveillance purposes to estimate trends over time and to design targeted intervention to reduce heat stress morbidity among at-risk populations.


Assuntos
Transtornos de Estresse por Calor/epidemiologia , Transtornos de Estresse por Calor/terapia , Hospitalização/tendências , Vigilância da População/métodos , Adolescente , Adulto , Distribuição por Idade , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Distribuição por Sexo , Estados Unidos/epidemiologia , Adulto Jovem
17.
Am J Mens Health ; 6(1): 28-36, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22105064

RESUMO

Sexual violence is a serious public health problem that has been associated with negative mental and physical health outcomes. Few existing studies have examined the prevalence and patterns of adverse mental health among victims of sexual violence using data from nationally representative samples of U.S. adults. The main objectives of this study were to identify patterns in the associations between sexual violence victimization and depression and anxiety (DA) symptoms using data from the sexual violence and DA Behavioral Risk Factor Surveillance System (BRFSS) modules. Stratified multivariate logistic regression models were conducted to test the associations between sexual violence victimization and DA controlling for demographic characteristics. Multiple stratified MANOVA models were used to detect the effect of sexual violence victimization on DA symptoms while controlling for key demographic characteristics. Among all 61,187 participants, more than 5% (n = 3,240) were victims of sexual violence, out of which 18.82% reported being diagnosed with depression, 8.37% reported an anxiety disorder, and 28.28% reported being diagnosed with DA disorder. Victims of sexual violence reported significantly higher number of days when they had trouble concentrating, sleep difficulties, poor appetite, little interest or pleasure in activities, blamed themselves for personal failure, felt depressed, and had little energy. The present study highlights the importance of collecting nationally representative data from victims of sexual violence and extends previous findings from clinically based studies. This study also serves as an example of an analytic approach that addresses a public health priority area by drawing on data from multiple topic-specific BRFSS modules.


Assuntos
Ansiedade/epidemiologia , Vítimas de Crime/estatística & dados numéricos , Depressão/epidemiologia , Saúde Mental/estatística & dados numéricos , Delitos Sexuais/estatística & dados numéricos , Maus-Tratos Conjugais/estatística & dados numéricos , Adulto , Ansiedade/psicologia , Sistema de Vigilância de Fator de Risco Comportamental , Comorbidade , Vítimas de Crime/psicologia , Depressão/psicologia , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Distribuição por Sexo , Delitos Sexuais/psicologia , Fatores Socioeconômicos , Maus-Tratos Conjugais/psicologia , Estados Unidos/epidemiologia , Adulto Jovem
18.
J Interpers Violence ; 27(3): 523-46, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21987510

RESUMO

Sexual assault among males, compared with females, is understudied, and may also be significantly underreported. Past studies have relied primarily on population-based survey data to estimate the prevalence of sexual assault and associated health outcomes. However, survey-based studies rely primarily on self-reports of victimization and may not accurately estimate the true prevalence of male sexual assault victimization. In order to obtain a detailed assessment of sexual assault among males, criminological databases like the National Incident Based Reporting System (NIBRS) may provide an important and unique source of information. The objective of the current study was to use data from the 2001-2005 NIBRS to construct an epidemiological profile of sexual assault among males. Our results suggest that the incidence of sexual assault was higher among young males (less than 19 years of age), with approximately 90% of all cases being reported among members of this age group. Among males of all ages, forcible fondling and sodomy were the most prevalent forms of sexual assault. Results from additional analyses include age- and race-specific rates of male sexual assault, the prevalence and severity of injury, and time trends detailing incidence by time of the day and location of the incident. Our analyses show that sexual assault is experienced by males of all age groups. However, the rate of sexual assault is higher among younger males. Despite some limitations, results from this study suggest that NIBRS data may provide a important complement to survey data for understanding breadth and consequences of male sexual assault.


Assuntos
Delitos Sexuais/estatística & dados numéricos , Comportamento Sexual/estatística & dados numéricos , Adolescente , Adulto , Negro ou Afro-Americano/estatística & dados numéricos , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Vítimas de Crime/estatística & dados numéricos , Criminosos , Bases de Dados Factuais , Humanos , Incesto/estatística & dados numéricos , Incidência , Lactente , Recém-Nascido , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Estados Unidos/epidemiologia , População Branca , Adulto Jovem
19.
Disaster Med Public Health Prep ; 6(3): 209-16, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23077263

RESUMO

OBJECTIVE: An 8.3 magnitude earthquake followed by tsunami waves devastated American Samoa on September 29, 2009, resulting in widespread loss of property and public services. An initial and a follow-up Community Needs Assessment for Public Health Emergency Response (CASPER) objectively quantified disaster-affected population needs. METHODS: Using a 2-stage cluster sampling method of CASPER, a household questionnaire eliciting information about medical and basic needs, illnesses, and injuries was administered. To assess response efforts, percent changes in basic and medical needs, illnesses, and injuries between the initial and follow-up CASPER were calculated. RESULTS: During the initial CASPER (N = 212 households), 47.6% and 51.6% of households reported needing a tarpaulin and having no electricity, respectively. The self-reported greatest needs were water (27.8%) and financial help with cleanup (25.5%). The follow-up CASPER (N = 207 households) identified increased vector problems compared to pre-tsunami, and food (26%) was identified as the self-reported greatest need. As compared to the initial CASPER, the follow-up CASPER observed decreases in electricity (-78.3%), drinking water (-44.4%), and clothing (-26.6%). CONCLUSION: This study highlights the use of CASPER during the response and recovery phases following a disaster. The initial CASPER identified basic needs immediately after the earthquake, whereas the follow-up CASPER assessed effectiveness of relief efforts and identified ongoing community needs.


Assuntos
Desastres , Avaliação das Necessidades , Saúde Pública , Tsunamis , Samoa Americana , Análise por Conglomerados , Intervalos de Confiança , Medicina de Emergência , Humanos , Pesquisa Qualitativa , Inquéritos e Questionários
20.
J Interpers Violence ; 25(8): 1523-41, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19940163

RESUMO

In the United States, an estimated three million men are victims of sexual violence each year, yet the majority of existing studies have evaluated the consequences and characteristics of victimization among women alone. The result has been a gap in the existing literature examining the physical and psychological consequences of sexual assault among men. The main objective of this study was to identify health outcomes, risk behaviors, and perpetrator/victim relationship characteristics among men who have experienced an attempted or completed sexual assault using data from the sexual violence module of the Behavioral Risk Factor Surveillance System survey. A total of 59,511 male respondents participated in the sexual violence module, and the majority of participants were White (73.7%), between the ages of 35 to 44 years (19.8%), married (69.0%), graduated from college (34.6%), and had an annual household income of more than US$50,000 (49.9%). Stratified multivariate logistic regression models were conducted to test the associations between victimization and health outcomes and risk behaviors controlling for age, marital status, race/ethnicity, income, education, and other potential confounders. Results of these analyses suggest important associations between health and sexual violence victimization. Specifically, men who reported unwanted attempted intercourse and attempted and completed intercourse were more likely to report poor mental health, poor life satisfaction, activity limitations, and lower emotional and social support. The current study extends knowledge of consequences of male sexual violence by considering characteristics of sexual assault and by identifying associations between victimization and a broad range of health indicators.


Assuntos
Vítimas de Crime/psicologia , Nível de Saúde , Assunção de Riscos , Delitos Sexuais/psicologia , Adolescente , Adulto , Idoso , Sistema de Vigilância de Fator de Risco Comportamental , Vítimas de Crime/estatística & dados numéricos , Comportamentos Relacionados com a Saúde , Humanos , Modelos Logísticos , Masculino , Saúde Mental , Pessoa de Meia-Idade , Delitos Sexuais/estatística & dados numéricos , Comportamento Sexual , Fatores Socioeconômicos , Estados Unidos/epidemiologia , Violência/psicologia , Adulto Jovem
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