Detalhe da pesquisa
1.
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling.
Nature
; 569(7757): 570-575, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31019297
2.
Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of ß-TrCP and GSK-3.
Biochem Soc Trans
; 43(4): 611-20, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26551701
3.
Molecular Characterization of Acquired Resistance to KRASG12C-EGFR Inhibition in Colorectal Cancer.
Cancer Discov
; 13(1): 41-55, 2023 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36355783
4.
Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes.
Proc Natl Acad Sci U S A
; 111(18): E1818-20, 2014 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24753562
5.
Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress.
Redox Biol
; 47: 102158, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34626892
6.
Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets.
Nat Rev Cancer
; 20(1): 57-70, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31806884
7.
Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.
Proc Natl Acad Sci U S A
; 108(1): E1-2; author reply E3-4, 2011 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21177433
8.
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.
Cell Metab
; 30(3): 525-538.e8, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31303424
9.
Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.
Mol Cell Biol
; 36(18): 2403-17, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27354066
10.
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
Nat Commun
; 6: 7066, 2015 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25967870
11.
Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance.
Mol Cell Biol
; 34(17): 3305-20, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24958099
12.
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
Mol Cell Biol
; 31(6): 1121-33, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21245377
13.
Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.
Antioxid Redox Signal
; 13(11): 1713-48, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20446772
14.
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.
Free Radic Biol Med
; 48(2): 357-71, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19914374