Detalhe da pesquisa
1.
Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling.
Molecules
; 29(8)2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38675561
2.
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction.
Bioorg Med Chem
; 84: 117256, 2023 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37003157
3.
Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors.
Int J Mol Sci
; 24(11)2023 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298312
4.
Discovery of Novel Trace Amine-Associated Receptor 5 (TAAR5) Antagonists Using a Deep Convolutional Neural Network.
Int J Mol Sci
; 23(6)2022 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35328548
5.
Virtual Screening in the Identification of Sirtuins' Activity Modulators.
Molecules
; 27(17)2022 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36080416
6.
Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors.
Int J Mol Sci
; 21(21)2020 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33138251
7.
Recent Strategic Advances in CFTR Drug Discovery: An Overview.
Int J Mol Sci
; 21(7)2020 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32244346
8.
Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses.
Molecules
; 25(7)2020 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32218301
9.
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1 receptor ligand antagonists.
Bioorg Med Chem
; 26(1): 295-307, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29229226
10.
Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance.
Molecules
; 23(1)2018 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29316712
11.
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands.
J Enzyme Inhib Med Chem
; 32(1): 214-230, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28114832
12.
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles.
J Enzyme Inhib Med Chem
; 32(1): 375-402, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28276287
13.
New arylsparteine derivatives as positive inotropic drugs.
J Enzyme Inhib Med Chem
; 32(1): 588-599, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28133984
14.
Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1.
Hum Mutat
; 37(11): 1202-1208, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27492805
15.
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2 receptor antagonists/inverse agonists.
Bioorg Med Chem
; 24(21): 5291-5301, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27624523
16.
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies.
Mol Divers
; 20(1): 77-92, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26290462
17.
Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine.
Angew Chem Int Ed Engl
; 55(38): 11397-402, 2016 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27440458
18.
In silico evaluation of human small heat shock protein HSP27: homology modeling, mutation analyses and docking studies.
Bioorg Med Chem
; 23(13): 3215-20, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25999205
19.
New Pyrazolyl Thioureas Active against the Staphylococcus Genus.
Pharmaceuticals (Basel)
; 17(3)2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38543162
20.
Cyclic diacyl thioureas enhance activity of corrector Lumacaftor on F508del-CFTR.
ChemMedChem
; 19(4): e202300391, 2024 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38105411