Detalhe da pesquisa
1.
The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.
Immunity
; 43(5): 870-83, 2015 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522984
2.
A Lipopeptidomimetic of Transcriptional Activation Domains Selectively Disrupts the Coactivator Med25 Protein-Protein Interactions.
Angew Chem Int Ed Engl
; 63(21): e202400781, 2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38527936
3.
Garcinolic Acid Distinguishes Between GACKIX Domains and Modulates Interaction Networks.
Chembiochem
; 24(21): e202300439, 2023 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37525583
4.
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat Chem Biol
; 17(7): 784-793, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34155404
5.
2-Aminobenzothiazoles in anticancer drug design and discovery.
Bioorg Chem
; 135: 106477, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36989736
6.
Unexpected specificity within dynamic transcriptional protein-protein complexes.
Proc Natl Acad Sci U S A
; 117(44): 27346-27353, 2020 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33077600
7.
Covalent inhibition of NSD1 histone methyltransferase.
Nat Chem Biol
; 16(12): 1403-1410, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32868895
8.
Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods.
Bioorg Med Chem
; 34: 115990, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33549906
9.
Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.
Proc Natl Acad Sci U S A
; 115(36): 8960-8965, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30127017
10.
Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.
Blood
; 132(12): 1279-1292, 2018 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30076146
11.
Menin regulates the serine biosynthetic pathway in Ewing sarcoma.
J Pathol
; 245(3): 324-336, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29672864
12.
Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?
Immunol Rev
; 263(1): 279-301, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25510283
13.
Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.
Gastroenterology
; 153(6): 1555-1567.e15, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28859856
14.
Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations.
Blood
; 136(25): 2958-2963, 2020 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33331926
15.
The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.
Blood
; 124(25): 3730-7, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25305204
16.
Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C.
Bioorg Med Chem
; 24(21): 5495-5504, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27647375
17.
NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation.
Mol Cell
; 31(6): 896-908, 2008 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18922471
18.
Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
Biochemistry
; 54(35): 5401-13, 2015 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26292256
19.
Stabilizing the Mixed Lineage Leukemia Protein.
N Engl J Med
; 376(17): 1688-1689, 2017 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28445666
20.
Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility.
Bioorg Med Chem Lett
; 25(13): 2720-5, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25987377