Detalhe da pesquisa
1.
A combined approach of structure-based virtual screening and NMR to interrupt the PD-1/PD-L1 axis: Biphenyl-benzimidazole containing compounds as novel PD-L1 inhibitors.
Arch Pharm (Weinheim)
; 357(3): e2300583, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38110703
2.
Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies.
J Enzyme Inhib Med Chem
; 34(1): 1697-1710, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31537132
3.
Oral Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users.
Pain Med
; 18(7): 1278-1291, 2017 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27651514
4.
Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users.
Pain Med
; 17(5): 820-31, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26814240
5.
Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-Ascending Doses of Sunobinop in Healthy Participants.
Clin Pharmacol Drug Dev
; 2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38476082
6.
Successes and challenges in the development of BD1-selective BET inhibitors: a patent review.
Expert Opin Ther Pat
; : 1-17, 2024 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38465537
7.
The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia.
J Clin Invest
; 134(1)2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37883189
8.
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
ChemMedChem
; : e202400139, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38752332
9.
NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors.
J Med Chem
; 66(17): 11632-11655, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37650225
10.
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
J Med Chem
; 66(19): 13665-13683, 2023 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37560786
11.
Lysine methyltransferase inhibitors: where we are now.
RSC Chem Biol
; 3(4): 359-406, 2022 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35441141
12.
Discovery of Benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain.
ChemMedChem
; 17(20): e202200343, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36040095
13.
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J Med Chem
; 65(17): 11574-11606, 2022 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35482954
14.
Targeting epigenetic reader domains by chemical biology.
Curr Opin Chem Biol
; 57: 82-94, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32739717
15.
Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure.
J Med Chem
; 62(5): 2666-2689, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30753076
16.
Dose-Dependent Flux of Buprenorphine Following Transdermal Administration in Healthy Subjects.
J Clin Pharmacol
; 56(10): 1263-71, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26865472
17.
Pharmacokinetic Profile and Sustained 24-hour Analgesia of a Once-daily Hydrocodone Bitartrate Extended-release Tablet with Abuse-deterrent Properties.
Clin Ther
; 38(2): 302-14, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26749219
18.
Clinical pharmacology and pharmacokinetics of once-daily hydromorphone hydrochloride extended-release capsules.
J Clin Pharmacol
; 45(5): 547-54, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15831778
19.
Effects of paroxetine, a CYP2D6 inhibitor, on the pharmacokinetic properties of hydrocodone after coadministration with a single-entity, once-daily, extended-release hydrocodone tablet.
Clin Ther
; 37(10): 2286-96, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26350273
20.
Once-weekly transdermal buprenorphine application results in sustained and consistent steady-state plasma levels.
J Pain Symptom Manage
; 46(1): 65-75, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23026548