Detalhe da pesquisa
1.
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors.
Bioorg Med Chem Lett
; 50: 128352, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34481987
2.
Corrigendum to "Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors" [Bioorgan. Med. Chem. Lett. 50 (2021) 128352].
Bioorg Med Chem Lett
; 67: 128758, 2022 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35484006
3.
The Preclinical Pharmacology of Tepotinib-A Highly Selective MET Inhibitor with Activity in Tumors Harboring MET Alterations.
Mol Cancer Ther
; 22(7): 833-843, 2023 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999986
4.
Preclinical evidence for the effective use of TL-895, a highly selective and potent second-generation BTK inhibitor, for the treatment of B-cell malignancies.
Sci Rep
; 13(1): 20412, 2023 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37989777
5.
p70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab.
Sci Rep
; 13(1): 16017, 2023 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37749105
6.
Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases.
Lung Cancer
; 163: 77-86, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34942492
7.
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
J Med Chem
; 64(19): 14603-14619, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34596404
8.
M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier.
Am J Cancer Res
; 6(4): 806-18, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27186432
9.
Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators.
Free Radic Biol Med
; 95: 243-54, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27021962
10.
Inhibiting aurora kinases reduces tumor growth and suppresses tumor recurrence after chemotherapy in patient-derived triple-negative breast cancer xenografts.
Mol Cancer Ther
; 11(12): 2693-703, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23012245
11.
LGBT Assisted Reproduction: Current Practice and Future Possibilities.
LGBT Health
; 1(3): 151-6, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26789706