Detalhe da pesquisa
1.
The oDGal Mouse: A Novel, Physiologically Relevant Rodent Model of Sporadic Alzheimer's Disease.
Int J Mol Sci
; 24(8)2023 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37108119
2.
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.
Neuron
; 56(1): 66-78, 2007 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17920016
3.
BACE1 structure and function in health and Alzheimer's disease.
Curr Alzheimer Res
; 5(2): 100-20, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18393796
4.
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.
J Neurosci
; 26(40): 10129-40, 2006 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17021169
5.
Aß reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level.
Mol Neurodegener
; 10: 1, 2015 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25567526
6.
Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1.
Neurobiol Aging
; 30(10): 1535-44, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18289733
7.
The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology.
J Biol Chem
; 283(44): 29621-5, 2008 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-18650431
8.
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
Neuron
; 60(6): 988-1009, 2008 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19109907
9.
The Alzheimer's disease beta-secretase enzyme, BACE1.
Mol Neurodegener
; 2: 22, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18005427
10.
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.
Neurobiol Dis
; 26(1): 134-45, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17258906
11.
Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.
J Biol Chem
; 280(19): 18755-70, 2005 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15718241