Detalhe da pesquisa
1.
Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations.
J Mol Cell Cardiol
; 186: 125-137, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38008210
2.
Drug discovery for heart failure targeting myosin-binding protein C.
J Biol Chem
; 299(12): 105369, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37865311
3.
Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET.
J Mol Cell Cardiol
; 166: 116-126, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35227736
4.
Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen.
J Biol Chem
; 297(1): 100840, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34052227
5.
Human cardiac myosin-binding protein C restricts actin structural dynamics in a cooperative and phosphorylation-sensitive manner.
J Biol Chem
; 294(44): 16228-16240, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31519753
6.
Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics.
Proc Natl Acad Sci U S A
; 113(12): 3233-8, 2016 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26908877
7.
N-terminal extension in cardiac myosin-binding protein C regulates myofilament binding.
J Mol Cell Cardiol
; 125: 140-148, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30359561
8.
Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury.
Am J Physiol Lung Cell Mol Physiol
; 312(3): L297-L308, 2017 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28062482
9.
Estradiol modulates myosin regulatory light chain phosphorylation and contractility in skeletal muscle of female mice.
Am J Physiol Endocrinol Metab
; 310(9): E724-33, 2016 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26956186
10.
The myosin super-relaxed state is disrupted by estradiol deficiency.
Biochem Biophys Res Commun
; 456(1): 151-5, 2015 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25446114
11.
Cardiac myosin binding protein-C restricts intrafilament torsional dynamics of actin in a phosphorylation-dependent manner.
Proc Natl Acad Sci U S A
; 109(50): 20437-42, 2012 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23169656
12.
Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation.
J Gen Physiol
; 155(3)2023 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36633587
13.
Drug discovery for heart failure targeting myosin-binding protein C.
bioRxiv
; 2023 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37066417
14.
Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.
J Mol Cell Cardiol
; 53(5): 609-16, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22850286
15.
Structural dynamics of muscle protein phosphorylation.
J Muscle Res Cell Motil
; 33(6): 419-29, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22930331
16.
A high-throughput fluorescence lifetime-based assay to detect binding of myosin-binding protein C to F-actin.
J Gen Physiol
; 153(3)2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33600558
17.
AZD2014, a dual mTOR inhibitor, attenuates cardiac hypertrophy in vitro and in vivo.
J Biol Eng
; 15(1): 24, 2021 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34674743
18.
Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development.
J Physiol
; 588(Pt 6): 981-93, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20123786
19.
Protein kinase A-mediated phosphorylation of cMyBP-C increases proximity of myosin heads to actin in resting myocardium.
Circ Res
; 103(3): 244-51, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18599866
20.
Radial displacement of myosin cross-bridges in mouse myocardium due to ablation of myosin binding protein-C.
J Mol Biol
; 367(1): 36-41, 2007 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17254601