Detalhe da pesquisa
1.
Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition.
Chembiochem
; 12(8): 1203-8, 2011 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21506232
2.
Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target.
Mol Pharmacol
; 76(1): 163-72, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19364812
3.
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.
J Med Chem
; 50(23): 5780-9, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17944451
4.
Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential.
Org Biomol Chem
; 6(4): 637-56, 2008 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18264564
5.
Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
Org Biomol Chem
; 5(22): 3665-73, 2007 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17971996
6.
Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles.
Bioorg Med Chem Lett
; 17(6): 1575-8, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17254788
7.
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.
Biochemistry
; 46(20): 5941-50, 2007 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17455910