Detalhe da pesquisa
1.
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level.
Annu Rev Biochem
; 2024 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346274
2.
Conformational transitions of the serotonin 5-HT3 receptor.
Nature
; 563(7730): 275-279, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30401839
3.
Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Cell Mol Life Sci
; 80(6): 164, 2023 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37231269
4.
Fumarate as positive modulator of allosteric transitions in the pentameric ligand-gated ion channel GLIC: requirement of an intact vestibular pocket.
J Physiol
; 601(12): 2447-2472, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37026398
5.
Concatemers to re-investigate the role of α5 in α4ß2 nicotinic receptors.
Cell Mol Life Sci
; 78(3): 1051-1064, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32472188
6.
Structural titration of receptor ion channel GLIC gating by HS-AFM.
Proc Natl Acad Sci U S A
; 115(41): 10333-10338, 2018 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30181288
7.
Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation.
Proc Natl Acad Sci U S A
; 115(17): E3959-E3968, 2018 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29632192
8.
Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel.
Proc Natl Acad Sci U S A
; 115(52): E12172-E12181, 2018 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30541892
9.
Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel.
PLoS Biol
; 15(12): e2004470, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29281623
10.
The dual-gate model for pentameric ligand-gated ion channels activation and desensitization.
J Physiol
; 596(10): 1873-1902, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29484660
11.
Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.
Proc Natl Acad Sci U S A
; 112(9): 2865-70, 2015 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25730860
12.
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels.
EMBO J
; 32(5): 728-41, 2013 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23403925
13.
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.
Nature
; 469(7330): 428-31, 2011 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21248852
14.
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.
Proc Natl Acad Sci U S A
; 111(3): 966-71, 2014 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24367074
15.
Intermediate closed state for glycine receptor function revealed by cysteine cross-linking.
Proc Natl Acad Sci U S A
; 110(42): 17113-8, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24085847
16.
Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.
Alcohol Clin Exp Res
; 39(6): 962-8, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25973519
17.
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation.
Nature
; 457(7225): 111-4, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18987633
18.
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.
Proc Natl Acad Sci U S A
; 109(44): E3028-34, 2012 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23035248
19.
Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment.
J Biol Chem
; 288(16): 11294-303, 2013 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23463505
20.
Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.
Proc Natl Acad Sci U S A
; 108(29): 12143-8, 2011 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21730130