Detalhe da pesquisa
1.
Pharmacokinetic and Metabolomic Studies with a Promising Radiation Countermeasure, BBT-059 (PEGylated interleukin-11), in Rhesus Nonhuman Primates.
Radiat Res
; 2024 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38714310
2.
Interleukin-11 protects against renal ischemia and reperfusion injury.
Am J Physiol Renal Physiol
; 303(8): F1216-24, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22859402
3.
Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation Syndrome.
Radiat Res
; 198(3): 221-242, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35834823
4.
Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes.
Front Pharmacol
; 12: 634477, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34079456
5.
Corrigendum: Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes.
Front Pharmacol
; 12: 741485, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34512365
6.
Characterization of a Long-Acting Site-Specific PEGylated Murine GM-CSF Analog and Analysis of Its Hematopoietic Properties in Normal and Cyclophosphamide-Treated Neutropenic Rats.
Protein J
; 39(2): 160-173, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32172395
7.
Delayed effects of acute whole body lethal radiation exposure in mice pre-treated with BBT-059.
Sci Rep
; 10(1): 6825, 2020 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32321983
8.
IFN-γ-tethered hydrogels enhance mesenchymal stem cell-based immunomodulation and promote tissue repair.
Biomaterials
; 220: 119403, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31401468
9.
Mitochondrial Degeneration and Autophagy Associated With Delayed Effects of Radiation in the Mouse Brain.
Front Aging Neurosci
; 11: 357, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31956306
10.
PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome.
Health Phys
; 115(1): 65-76, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29787432
11.
A long-acting, mono-PEGylated human growth hormone analog is a potent stimulator of weight gain and bone growth in hypophysectomized rats.
Endocrinology
; 148(4): 1590-7, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17234711
12.
Design of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivity.
Exp Hematol
; 34(6): 697-704, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16728273
13.
Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein.
Exp Hematol
; 32(5): 441-9, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15145212
14.
Cytokine refacing effect reduces granulocyte macrophage colony-stimulating factor susceptibility to antibody neutralization.
Protein Eng Des Sel
; 28(10): 461-6, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25855658
15.
PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome.
Health Phys
; 106(1): 7-20, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24276546
16.
Hematopoietic properties of granulocyte colony-stimulating factor/immunoglobulin (G-CSF/IgG-Fc) fusion proteins in normal and neutropenic rodents.
PLoS One
; 9(3): e91990, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24637521
17.
PEGylation improves the pharmacokinetic properties and ability of interferon gamma to inhibit growth of a human tumor xenograft in athymic mice.
J Interferon Cytokine Res
; 34(10): 759-68, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24841172
18.
Site-specific PEGylation enhances the pharmacokinetic properties and antitumor activity of interferon beta-1b.
J Interferon Cytokine Res
; 33(12): 769-77, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23962003
19.
Enhanced circulating half-life and antitumor activity of a site-specific pegylated interferon-alpha protein therapeutic.
Bioconjug Chem
; 19(1): 299-305, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18020402
20.
A long-acting, highly potent interferon alpha-2 conjugate created using site-specific PEGylation.
Bioconjug Chem
; 16(1): 200-7, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15656592