Detalhe da pesquisa
1.
Efficacy and safety of trametinib in Japanese patients with advanced biliary tract cancers refractory to gemcitabine.
Cancer Sci
; 109(1): 215-224, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29121415
2.
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.
Nature
; 492(7427): 108-12, 2012 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23051747
3.
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).
Proc Natl Acad Sci U S A
; 109(8): 2989-94, 2012 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22323599
4.
The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.
J Biol Chem
; 288(12): 8762-8771, 2013 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23386615
5.
Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues.
Sci Rep
; 10(1): 22155, 2020 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33335114
6.
Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors.
ACS Med Chem Lett
; 11(2): 133-140, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071679
7.
Genomic landscape of lung adenocarcinoma in East Asians.
Nat Genet
; 52(2): 177-186, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32015526
8.
Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer.
Nat Med
; 25(3): 403-418, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30842676
9.
Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors.
Clin Cancer Res
; 25(24): 7331-7339, 2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31471312
10.
Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.
Cancer Discov
; 9(7): 872-889, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31076479
11.
A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1.
SLAS Discov
; 23(1): 34-46, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28957646
12.
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.
Mol Cell Biol
; 24(22): 9848-62, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15509788
13.
Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.
Sci Transl Med
; 9(378)2017 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28228601
14.
The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.
Nat Commun
; 6: 6051, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25609585
15.
EZH2 as a potential target in cancer therapy.
Epigenomics
; 6(3): 341-51, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25111487
16.
Long residence time inhibition of EZH2 in activated polycomb repressive complex 2.
ACS Chem Biol
; 9(3): 622-9, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24304166
17.
A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation.
Mol Cancer Ther
; 13(12): 3062-73, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25253781
18.
Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer.
Oncotarget
; 4(12): 2419-29, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24293458
19.
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
Cancer Cell
; 23(5): 677-92, 2013 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23680150
20.
Untangling the role of mutant histone H3 in diffuse intrinsic pontine glioma.
Nat Med
; 23(4): 413-414, 2017 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28388610