1.
Bioorg Med Chem Lett
; 20(2): 759-62, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20005096
RESUMO
The optimisation of an HTS hit series (1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 positive modulators GSK1331258 and GSK1331268 is described. Structure-activity relationships, attenuation of dopaminergic activity, and potentiation of mGluR2 responses in rat hippocampal MPP-DG synapses are also reported.