Detalhe da pesquisa
1.
Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction.
J Neurosci
; 39(42): 8217-8224, 2019 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31619490
2.
Misfolded SOD1 is not a primary component of sporadic ALS.
Acta Neuropathol
; 134(1): 97-111, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28247063
3.
Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.
Acta Neuropathol
; 133(6): 907-922, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28357566
4.
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.
Proc Natl Acad Sci U S A
; 110(8): E736-45, 2013 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23382207
5.
Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis.
J Neurosci
; 33(11): 4657-71, 2013 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23486940
6.
Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.
J Biol Chem
; 288(35): 25266-25274, 2013 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23867462
7.
14-3-3θ, a novel player in TDP-43 pathophysiology: Implications for ALS/FTD.
Neuron
; 112(8): 1197-1199, 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38636451
8.
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS.
Mol Neurodegener
; 19(1): 46, 2024 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38862967
9.
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS.
bioRxiv
; 2024 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38895337
10.
SLP-2 is required for stress-induced mitochondrial hyperfusion.
EMBO J
; 28(11): 1589-600, 2009 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19360003
11.
Lost in local translation: TDP-43 and FUS in axonal/neuromuscular junction maintenance and dysregulation in amyotrophic lateral sclerosis.
Neuron
; 111(9): 1355-1380, 2023 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36963381
12.
Current Methods In ALS Research.
J Vis Exp
; (193)2023 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37602847
13.
Molecular convergence of bacterial and eukaryotic surface order.
J Biol Chem
; 286(47): 40631-7, 2011 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21965671
14.
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB.
Nat Neurosci
; 24(8): 1089-1099, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34083786
15.
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells.
Science
; 371(6529)2021 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33335017
16.
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.
Mol Neurodegener
; 16(1): 61, 2021 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34488813
17.
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72.
Nat Neurosci
; 23(5): 615-624, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32284607
18.
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS.
Nat Med
; 26(1): 118-130, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31873312
19.
SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability.
Biochim Biophys Acta
; 1783(5): 904-11, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18339324
20.
Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.
Mol Cell Biol
; 26(20): 7397-408, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17015472