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1.
BMC Public Health ; 22(1): 1949, 2022 10 20.
Artigo em Inglês | MEDLINE | ID: mdl-36266647

RESUMO

OBJECTIVES: Protective vaccinations are important in maintaining health and reducing suffering from infectious diseases. Also, vaccine-preventable infectious diseases are associated with the development and progression of cardiovascular diseases. AIM: The study aimed to test adults' knowledge of the role of protective vaccinations in the prevention of cardiovascular diseases, and their opinions on the quantity of the information provided by doctors in this regard. METHODS: A total of 700 adults participated in the study, most of whom were women (500; 71.43%). The study used an original questionnaire containing questions covering vaccinations and cardiovascular diseases, and the general characteristics of the participants. The inclusion criteria for the study were 18 years of age and written informed consent to participate in the study. RESULTS: Over 60% of the participants did not know of, or denied the possibility of, developing cardiovascular diseases as a result of avoiding required preventive vaccinations. More than half of the participants stated that there is no need to recommend influenza vaccination to patients with cardiovascular diseases. Over 70% of participants stated that family doctors did not provide sufficient information about protective vaccinations. CONCLUSION: In these adults, knowledge of the role of preventive vaccinations in the prevention of cardiovascular diseases was low, and the quantity of the information provided by doctors about preventive vaccinations were considered to be insufficient. Public awareness of the effects of avoiding preventive vaccinations should be raised especially among people with CVD.


Assuntos
Doenças Cardiovasculares , Doenças Transmissíveis , Vacinas , Adulto , Humanos , Feminino , Masculino , Doenças Cardiovasculares/prevenção & controle , Conhecimentos, Atitudes e Prática em Saúde , Vacinação
2.
BMC Public Health ; 22(1): 2342, 2022 12 14.
Artigo em Inglês | MEDLINE | ID: mdl-36517763

RESUMO

BACKGROUND: Protective vaccinations are one of the basic means of infectious disease prevention. The aim of the study was to assess the implementation of compulsory and additional protective vaccinations among adult Poles, their knowledge about the purpose of introducing a vaccination schedule and adverse events following immunization. Opinions about and support for anti-vaccination movements were also examined. MATERIALS AND METHODS: A total of 700 (100%) people aged 18 to 80 (x̅ = 32,16 ± 16,46) took part in the study, conducted using the proprietary questionnaire. All the participants selected randomly from patients of the Department of Cardiology, their visitors, doctors, nurses, paramedics, medical students, and authors' acquaintances gave their informed consent to participate in the study. RESULTS: About 10% of the respondents did not complete the compulsory vaccination schedule. Almost 80% of respondents believed that the main reason for vaccinations schedule occurrence was the desire to completely exclude certain diseases and their complications from the population. More than half of the respondents have never had any additional vaccination. A statistically significant correlation was found between intake of at least one additional vaccination and age (χ2=22.262, p = 0.002) and education level (χ2= 11.074, p = 0.004). Among the respondents, there was a group that classified autism as one of the adverse events following immunization. About 95% of respondents never experienced any adverse events following immunizationand as many as 30 respondents declared their support for anti-vaccination movements. CONCLUSION: The degree of the implementation of compulsory protective vaccinations in the study group was high, while additional vaccinations were insufficient. The purposefulness of introducing a vaccination schedule was correctly identified by the majority of the respondents, but the knowledge about adverse events following immunisation and their types was incomplete. Among participants were individuals who declared their support for anti-vaccination movements, so society should be constantly educated about vaccinations benefits.


Assuntos
Doenças Transmissíveis , Vacinação , Adulto , Humanos , Esquemas de Imunização , Imunização , Inquéritos e Questionários , Conhecimentos, Atitudes e Prática em Saúde
3.
BMC Public Health ; 21(1): 1392, 2021 07 13.
Artigo em Inglês | MEDLINE | ID: mdl-34256706

RESUMO

BACKGROUND: The vaccine is a preparation of biological origin containing antigens that stimulate the body's immune system to produce acquired immunity. Vaccines can contain killed or "live" (attenuated) microorganisms as well as fragments of these (antigens). Although many vaccines are used routinely in pregnancy to provide a seroprotective immune response for mother, fetus and neonate there is much controversy over their use during this unique time. The aim of the study was to find out about the knowledge of adult Poles on the use of preventive vaccinations during pregnancy. METHODS: The study involved 700 people (100%) aged 18 to 80 years ([Formula: see text] = 32.16 ± 16.46). Most of the respondents were women (511; 73%). The study consisted of 9 questions about preventive vaccinations of pregnant women and 5 questions about members of the studied group. The aforementioned questions formed the basis of the preparation of the presented article. RESULTS: A significant part of respondents (322; 46%) did not have knowledge on the topic of safeness of using preventive vaccinations during pregnancy, 196 (28%) respondents believed that such procedure is not safe. Most of the respondents (371; 53%) did not know about the possibility of using "live" vaccines during pregnancy. 14 (2%) of respondents believed that pregnancy should be terminated in case of administration of a "live" vaccine to a pregnant woman. According to 294 (42%) respondents, vaccinations with "live" vaccines should be completed at least 3 months before the planned pregnancy. The subjects were not aware of the issue of post-exposure vaccination against tetanus and rabies among pregnant women. The respondents' responses were divided on the issue of the safest trimester of pregnancy for vaccine administration. Almost 1/3 of the respondents (203; 29%) indicated the third trimester as the safest for their performance. CONCLUSION: The knowledge of the surveyed group, the majority of whom were women, about the use of vaccinations before and during pregnancy was unsatisfactory. There is a need to educate the public about the benefits and risks of performing or avoiding preventive vaccinations during pregnancy.


Assuntos
Complicações Infecciosas na Gravidez , Vacinação , Adulto , Feminino , Humanos , Imunização , Recém-Nascido , Masculino , Gravidez , Gestantes , Vacinas Atenuadas
4.
Wiad Lek ; 74(8): 2004-2010, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34537757

RESUMO

Both architecture and medicine have accompanied man for centuries. Both architects and doctors make every effort to ensure that the objects of their interest (buildings and the human body) comply with the Vitruvian principles of ideal construction. Doctors take steps to restore these principles in the event of a disease, and like architects, they try to keep the subject of their activities as long as possible. It can be said that this two professions have a common ancestor: the first physician known by name in general history - Imhotep - was not only an outstanding doctor, but also an architect. He designed and built the funerary complex in Saqqara on the basis of a combination of different types of burials from lower and upper Egypt. He also was the author of the prototype of the Edwin Smith Papyrus, discovered in Luxor, a document containing the rational and scientific approach of ancient physicians to diseases for which science dominates over magic. Historians are debating whether it is Imhotep, and not Hippocrates, who should be called the father of medicine. The 21st century forces both doctors and architects to take up newer and newer challenges and change standards. Both of these professions today are based on the service provider-recipient relationship. According to modern technologies, they both work in accordance with the guidelines displayed on the computer screen. Doctors take responsibility for human health and life, while architects - for interpersonal relationships created in the buildings they have designed.


Assuntos
Médicos , Atenção à Saúde , História Antiga , Humanos , Masculino
5.
J Nurs Manag ; 28(7): 1725-1739, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32772471

RESUMO

AIM: To evaluate the factors affecting the health-related behaviours among nurses in Poland, including the influence of Type D personality. BACKGROUND: Some nurses appear to adopt an unhealthy lifestyle to cope with the stressful nature of their work, which can affect their professional performance and contribute to the burden on our health care system. However, the factors driving the health-related behaviours among nurses in Poland have not been adequately studied. METHOD: This was a descriptive study conducted from June 2017 to May 2018 among nurses (N = 1,080) working primary care or in training facilities in Silesia, Poland. Data were acquired through a series of questionnaires and are presented as descriptive statistics. RESULTS: A total of 379 (35%) nurses consumed alcohol in a harmful way, and ~20% were smokers. Almost all nurses (94.5%) could make dietary improvements. Over half (68%) reported moderate stress levels, and 179 (16.6%) were extremely stressed. Compared with non-Type D individuals, nurses with Type D personality more commonly used ineffective techniques for dealing with stress (i.e. denial and abreaction; p <.001), had lower mood (p <.001) and had a poorer diet (p = .001). CONCLUSION: The majority of nurses in Poland lead an unhealthy lifestyle and report moderate to severe levels of stress. Nurses with Type D personality more commonly use ineffective techniques for dealing with stress (i.e. avoidance strategies), have lower mood and have a poorer diet than those with non-Type D personality. IMPLICATIONS FOR NURSING MANAGEMENT: Promoting healthy behaviours and developing stress management techniques among nurses, particularly those with Type D personality, may improve nurses' well-being and professional performance, and help set a better example for patients.


Assuntos
Enfermeiras e Enfermeiros , Personalidade Tipo D , Adaptação Psicológica , Comportamentos Relacionados com a Saúde , Humanos , Polônia , Inquéritos e Questionários
6.
Medicina (Kaunas) ; 56(9)2020 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-32933100

RESUMO

Background and objectives: Recommendations for the control of stable patients with coronary artery disease (CAD) related to an adequate level of physical activity (PA). Practical experience shows that the PA level in most people with CAD is definitely too low in relation to the guidelines. The cause may be psychological factors and among them the fear of movement-kinesiophobia. The aim of this project was to examine the evaluation of psychometric features of the Polish version of the Tampa Scale for Kinesiophobia Heart (TSK Heart), used in people with CAD. Materials and methods: The study involved 287 patients with stable CAD: 112 women and 175 men. Age: 63.50 (SD = 11.49) years. Kinesiophobia was assessed using TSK Heart, physical activity (PA)-using the International Physical Activity Questionnaire (IPAQ), and anxiety and depression was examined using the Hospital Anxiety and Depression Scale (HADS). The structure of TSK was examined using principal component analysis (PCA), internal cohesion (Cronbach's alpha, AC), and content validity was calculated by linear regression. Results: PCA showed a three-factor TSK structure. One-dimensionality and satisfactory reliability were found: TSK Heart: AC = 0.878. Kinesiophobia as a predictor of PA: R2 = 0.162 (p = 0.000000). Anxiety and depression-TSK: R2 = 0.093 (p = 0.00000). Conclusions: The Polish version of TSK Heart for cardiac patients is characterized by good psychometric features. The use of it can improve the cooperation of rehabilitation teams for patients with CAD.


Assuntos
Doença da Artéria Coronariana , Transtornos Fóbicos , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Polônia , Psicometria , Reprodutibilidade dos Testes , Inquéritos e Questionários
7.
Int J Clin Pharmacol Ther ; 56(9): 393-399, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29809132

RESUMO

INTRODUCTION: Cardiovascular disease is the leading global cause of death. Its development is largely determined by lifestyle and cardiovascular risk factors, among which arterial hypertension (HT) plays a key role. Available data indicate a significant role of inflammation in the pathophysiology of HT. OBJECTIVES: The aim of this study was to assess concentrations of mediators of inflammation in patients with mild and moderate HT and its modulation with antihypertensive treatment. MATERIALS AND METHODS: 56 subjects: 17 with first- and 20 with second-grade HT, and 19 healthy subjects constituting a control group. Antihypertensive therapy: in first-grade HT, perindopril 5 mg daily, and in second-grade HT, bisoprolol (5 mg daily) additionally were ordered. Before and after a 4-week treatment, interleukine-2, interferon-γ, and high-sensitivity C-reactive protein serum concentrations were assessed. RESULTS: hs-CRP concentration was higher in hypertensive patients, and the difference was statistically significant in patients with second-grade HT compared to the control group (1.42 mg/L vs. 2.55 mg/L; p = 0.003). Antihypertensive treatment was associated with hs-CRP decrease. IL-2 concentration was 14.8% (p = 0.005) higher in first- and 22.2% (p = 0.002) higher in second-grade HT compared to the controls. Treatment significantly reduced concentration of IL-2. IFN-γ concentrations, compared to the control group, were higher by 19.6% (p < 0.001) and 39.9% (p < 0.001) in 1st and 2nd grade HT, respectively. CONCLUSION: Increased values of blood pressure were accompanied by higher concentrations of cytokines and hs-CRP. Reversal of adverse T-cell stimulation was observed after 4-week therapy.
.


Assuntos
Antagonistas de Receptores Adrenérgicos beta 1/uso terapêutico , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Anti-Hipertensivos/uso terapêutico , Pressão Arterial/efeitos dos fármacos , Bisoprolol/uso terapêutico , Proteína C-Reativa/metabolismo , Hipertensão/tratamento farmacológico , Interferon gama/sangue , Interleucina-2/sangue , Ativação Linfocitária/efeitos dos fármacos , Perindopril/uso terapêutico , Linfócitos T/efeitos dos fármacos , Adulto , Biomarcadores/sangue , Estudos de Casos e Controles , Feminino , Humanos , Hipertensão/sangue , Hipertensão/diagnóstico , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Linfócitos T/imunologia , Linfócitos T/metabolismo , Fatores de Tempo , Resultado do Tratamento
8.
Pol Merkur Lekarski ; 39(233): 297-304, 2015 Nov.
Artigo em Polonês | MEDLINE | ID: mdl-26637095

RESUMO

UNLABELLED: Horse riding becoming increasingly common and popular form of recreation and leisure activities. However, enforced, proper posture while riding a horse, may contribute to decrease mobility of spine and lead to occurrence back pain. AIM: The aim of this study was to assess the impact of the systematic training of horse riding on the global mobility of the spine and back pain prevalence in-training horse riders professionally and recreational. MATERIALS AND METHODS: The study included 70 horse riders. The subjects were divided into two groups: 1) professional horse riders (n=50; 71.43%) or 2) a group of subjects who train for recreation (n=20; 28.57%). Performed functional tests to assess the range of motion of the spine. The study used an original survey about exercise intensity and occurrence pain complaints. RESULTS: It has been shown statistically significant difference in the measurement range of the global spine mobility between professional horse riders and recreational horse riders (p<0.007). Professional horse riders have often limited range of motion of the spine. It was also observed that every fifth (20%) professional horse rider and one in four (25%) subject which training recreational experience back pain during training and it is dependent upon the mobility of the spine (p <0.04). CONCLUSIONS: In professional horse riders more often seen limitation of global mobility of the spine compared with subjects who training recreational while the occurrence of back pain was related in both group - in professional and recreational horse riders.


Assuntos
Postura/fisiologia , Amplitude de Movimento Articular/fisiologia , Coluna Vertebral/fisiologia , Esportes/fisiologia , Adulto , Idoso , Animais , Dor nas Costas/epidemiologia , Feminino , Cavalos , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Esportes/estatística & dados numéricos
9.
Pol Merkur Lekarski ; 39(232): 205-8, 2015 Oct.
Artigo em Polonês | MEDLINE | ID: mdl-26608485

RESUMO

UNLABELLED: The primary goal of application soft tissue techniques is to restore the proper mobility of fascia. Disturbance of soft tissue mobility can cause disorder in deep tissues and lead to musculoskeletal dysfunction. AIM: The aim of the study was to evaluate the effectiveness of soft tissues techniques of spine area to thoracic and spine mobility. MATERIALS AND METHODS: Examined 30 subjects (15 women and 15 men) aged: x=19.9±1.2. Were performed measurements: mobility of the thorax, flexibility of the trunk in planes: sagittal and frontal. Then applied selected soft tissue techniques of spine area. Immediately after the therapy measurements were repeated. RESULTS: Occurred increase mobility and flexibility among women statistically significant. Among men, the increase in mobility occurred in all measurements in addition to the finger-floor test and horizontal range of arms. CONCLUSIONS: The application of soft tissue techniques may favorably influence on increasing mobility of thoracic and trunk flexibility. Confirmation results of the observations in other studies may be part of the improvement in the rehabilitation proceedings.


Assuntos
Coluna Vertebral/fisiopatologia , Terapia de Tecidos Moles/métodos , Adulto , Feminino , Humanos , Masculino , Doenças Musculoesqueléticas/reabilitação , Amplitude de Movimento Articular , Recuperação de Função Fisiológica , Fatores Sexuais , Vértebras Torácicas/fisiopatologia , Adulto Jovem
10.
Reumatologia ; 53(1): 46-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-27407225

RESUMO

About 10% of patients with Lyme disease continue to experience musculoskeletal pain and cognitive dysfunction after recommended antibiotic treatment. This condition is called post-Lyme disease syndrome (PLDS) or post-treatment Lyme disease syndrome. These two terms are used interchangeably. The pathogenesis of PLDS has been controversial. The hypothesis that patients with PLDS may harbor hidden reservoirs of Borrelia burgdorferi after their initial antibiotic treatment is difficult to accept. The prospective, double-blind studies contradict this point of view. Also, recently published research applying xenodiagnosis to PLDS supports the opinion that PLDS most likely has an autoimmune background. Lengthy courses of antibiotics are not justified in patients with PLDS because of the lack of benefit, and they are fraught with hazards. Most patients with PLDS recover from persistent symptoms with time. However, it can take months before they feel completely well.

11.
Front Public Health ; 12: 1375238, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38500727

RESUMO

Introduction: UTA can provide older adult people with the satisfaction of needs and creates the opportunity to pursue youthful interests and passions. The aim of the study was to assess selected elements of the lifestyle of Silesian seniors, taking into account their participation in the activities of Universities of the Third Age. Methods: The study involved 631 (100%) senior residents of the Silesian agglomeration. The majority of the study group were women (475; 75.28%), and the average age of the participants was 70.28 ± 6.09 years. To conduct the study, an original survey questionnaire was used, complemented by PPS-10, PAQE and Yesavage Geriatric Depression Rating Scale. Results: Among the surveyed Silesian seniors who did not attend classes at the University of the Third Age, a statistically significantly higher score on the Yesavage's Geriatric Depression Rating Scale was found compared to those confirming their participation in the mentioned activity (p = 0.002). Almost 40% (107; 38.63%) of seniors who did not attend classes at the Universities of the Third Age showed a high level of stress, and every fourth (89; 25.14%) Silesian senior taking part in the above-mentioned activity had a low level of stress (p = 0.04). The median of points obtained on the physical activity assessment scale (PAQE) by seniors attending classes at Universities of the Third Age was statistically higher than seniors who denied participation in the mentioned activity (p = 0.017). Conclusion: Participation in the various activities at the Universities of the Third Age influenced positively well-being, reduced stress and raised physical activity of examined seniors. It is important to promote and start actions leading to seniors' better and easier inclusion to the society life. Future research should concentrate on reasons why many seniors do not attend activities in their leisure time - especially on accessibility of various activities and financial reasons, which in the future will play crucial role in the aging societies.


Assuntos
Envelhecimento , Estilo de Vida , Humanos , Masculino , Feminino , Idoso , Pessoa de Meia-Idade , Universidades , Inquéritos e Questionários , Exercício Físico
12.
Biomedicines ; 12(3)2024 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-38540214

RESUMO

The aim of the study was to assess the occurrence of classic risk factors in the study group of patients with heart failure and to link them with the transcriptional activity of the examined genes: metalloproteinase 9 (MMP-9) and the tissue inhibitor of metalloproteinases 1 (TIMP-1). A total of 150 (100%) patients qualified for the study, including 80 (53.33%) patients with heart failure in the course of coronary artery disease, 40 (26.67%) with coronary artery disease without heart failure, and 30 (20.00%) in whom the presence of atherosclerotic changes in the coronary arteries was excluded. The material for molecular tests was peripheral blood collected from patients within the first 24 h of hospitalisation. A quantitative analysis of transcriptional activity was performed using the RT-qPCR technique. The most common classic risk factors among the patients in the study group were arterial hypertension (117; 78.00%) and overweight/obesity (102; 68%). In the group of patients with coronary artery disease and heart failure burdened with overweight/obesity, a significantly higher transcriptional activity of the metalloproteinase 9 (MMP-9) gene was found in comparison to patients who were not burdened with this risk factor. The analysis also showed the statistically significant higher transcriptional activity of the metalloproteinase 9 (MMP-9) gene in a group of patients with coronary artery disease and heart failure who smoked. The examined patients with heart failure due to myocardial ischemia were burdened with numerous cardiovascular risk factors, the most common of which were arterial hypertension, obesity/overweight, and hypercholesterolemia. A significant increase in the transcriptional activity of the metalloproteinase 9 (MMP-9) gene in the presence of risk factors (male sex, overweight/obesity, smoking) indicates another pathomechanism of their action and participation in the development and progression of heart failure during myocardial ischemia. There is a need for systematic information and educational activities promoting a healthy lifestyle with the elimination of modifiable risk factors for cardiovascular diseases.

13.
Biomedicines ; 11(10)2023 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-37893149

RESUMO

The most common cause of heart failure (HF) is coronary artery disease (CAD). The aim of this study was to evaluate the transcriptional activity of the metalloproteinase 9 (MMP-9) and tissue metalloproteinase inhibitor 1 (TIMP-1) genes in a study group of patients with HF due to CAD and in the control group, as well as assess the transcriptional activity of the examined genes, taking into account the number of affected coronary arteries and the severity of heart failure. The study group consisted of a total of 150 (100%) patients. The material for the study was peripheral blood, and molecular tests were performed using the quantitative QRT-PCR technique. The transcriptional activity of the MMP-9 gene was significantly higher in the group of patients with CAD and HF. It was also significantly higher with the progression of heart failure. TIMP-1 gene transcriptional activity was significantly lower with the advancement of heart failure. The transcriptional activity of the MMP-9 and TIMP-1 genes differentiated the examined patients. The severity of HF, and a significant increase in the QRT-PCR transcriptional activity of the MMP-9 gene with a simultaneous decrease in the activity of the TIMP-1 gene, makes them useful diagnostic and prognostic markers in clinical practice.

14.
Minerva Pediatr (Torino) ; 75(5): 650-659, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31833347

RESUMO

BACKGROUND: Movement and physical activity are the natural needs of a living human. Sedentary lifestyle resulting from the development of car communication, improper nutrition, abuse of drugs and addictive substances, constant rush and stress consequently cause destructive health effects. The aim of the study was to analyze risky behaviors among adolescents in the Silesian voivodeship (Poland), taking into account their resistance to stress and physical activity. METHODS: Two hundred eleven people were examined (100%). Among them there were 122 girls (57.82%) and 89 boys (42.18%) aged 16 to 18 years (x=17.3, SD=0.53). The participants were students from upper secondary schools in the Silesian voivodeship. The research tool was an original questionnaire consisting of a metric part, closed questions related to the examined problem and a standardized questionnaire of physical activity (Subjective Experience of Work Load [SEWL]). RESULTS: Most of the girls (47, 38.52%) considered themselves to be medically resistant to stress, while boys (30, 33.71%) believed they were rather resistant to stress. On the other hand, there was no correlation between susceptibility to stress of adolescents in relation to age. From the whole group, up to 203 people (96.21%) have already drunk alcohol. Among them there were 117 girls (95.90%) and 86 boys (96.63%). The first cigarette from the studied group of teenagers was ignited by 137 people (64.93%), including 80 girls (65.57%) and 57 boys (64.04%), while psychoactive substances have been already taken by 51 participants (24.17%). Among them there were 23 girls (18.85%) and 28 boys (31.46%). There was no correlation between the self-esteem of susceptibility to stress and the use of stimulants in both boys and girls. The average value of the Sport Index among girls was 2.75, while among boys was 6.37. CONCLUSIONS: Boys in comparison to girls considered themselves more resistant to stress, while the age in both sexes did not affect self-assessment of vulnerability to stress. Gender of the adolescents did not affect the frequency of stimulants use.


Assuntos
Exercício Físico , Esportes , Masculino , Feminino , Humanos , Adolescente , Estudantes , Inquéritos e Questionários , Comportamento Sexual
15.
Biomarkers ; 17(4): 379-83, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22423632

RESUMO

OBJECTIVE: Using oligonucleotide microarrays HG-U133A, we here studied the expression levels of genes that could differentiate between patients with myocardial infarction (MI) from healthy subjects, as well as to select among such genes those that seem crucial for manifestation of cardiovascular diseases. MATERIALS AND METHODS: The microarray study was conducted using material derived from blood samples collected in 17 individuals. RESULTS: Analysis of gene expression data from 17 microarrays allowed identification of 28 genes strongly differentiating the examined groups. CONCLUSION: The differentiating genes that we tracked down indicate possible linkage with atherosclerotis and could be a prognostic marker for development of cardiovascular diseases.


Assuntos
Perfilação da Expressão Gênica , Infarto do Miocárdio/genética , Análise de Sequência com Séries de Oligonucleotídeos , Doença Aguda , Biomarcadores , Estudos de Casos e Controles , Análise por Conglomerados , Genes , Humanos , Técnicas de Diagnóstico Molecular , Infarto do Miocárdio/diagnóstico , Infarto do Miocárdio/metabolismo
16.
Pol Merkur Lekarski ; 33(194): 90-6, 2012 Aug.
Artigo em Polonês | MEDLINE | ID: mdl-23009006

RESUMO

UNLABELLED: The prevalence of diseases of the cardiovascular system is the cause of their frequent use, and thus, easy availability of drugs acting on the cardiovascular system, including people they do not require. In Poland, annually are taken from 4.5 to 5.5 thousand suicide attempts, about 3.7% of them due to excessive consumption of pharmaceuticals. The aim of this study was to analyze patients who for suicidal attempts ingested drugs acting on the cardiac conduction system, and to study performed diagnostic and therapeutic procedures and obtained results. MATERIAL AND METHODS: The study included all hospitalized in the years 1995-2010 in the Department of Anesthesiology and Intensive Care patients after excessive suicidal ingestion of drugs acting on the heart conductive system. The study group comprised a total of 40 patients aged from 15 to 70 years. RESULTS: Suicide attempts in the study group were mostly taken by the lonely people and by the subjects with disturbed adaptation. The patients were unconscious mainly after ingestion of psychotropic drugs. From the 40-person group of patients after suicidal ingestion of drugs affecting the conduction system of heart eight patients (20%) required respirator. It has not been shown that any group of drugs significantly more frequent induced respiratory distress requiring mechanical assistance. Rhythm and conduction disturbances during hospitalization occurred in 15 patients (38%), of which 12 (30%) required temporary endocardial stimulation. The study revealed the longest ventricular stimulation need in patients after consumption of calcium channel blockers. Blood pressure in half of the patients was depressed, and 15 of them (38%) required the use of pressor amines. From the 40-person group 2 people died (one patient after ingestion of 4000 mg of propranolol and the other after eating 6000 mg of verapamil). Patients who died differed from the other patients with in younger age, longer time elapsed since the consumption of drugs to their hospitalization, during admission they had undetectable blood pressure, bradycardia, and decreased serum potassium levels. The remaining 38 patients (95%) were discharged from the Department of Anesthesiology and Intensive Care. CONCLUSIONS: Attempts to take his own life with the use of drugs in the cardiac conduction system in the study group were taken by a lonely and adaptive disturbances. The most commonly used preparations for suicide were beta-adrenergic receptors blockers, whereas hemodynamic abnormalities, arrhythmias and conduction disturbances were observed more frequently after the drugs that block calcium channels. In patients with life-saving use in suicide attempts important role in addition to medication dosage plays an elapsed time of their consumption and speed of action taken to remove and prevent absorbtion the poison", as well as close supervision in the intensive care unit.


Assuntos
Arritmias Cardíacas/induzido quimicamente , Arritmias Cardíacas/epidemiologia , Bloqueadores dos Canais de Cálcio/intoxicação , Sistema de Condução Cardíaco/efeitos dos fármacos , Psicotrópicos/intoxicação , Tentativa de Suicídio/estatística & dados numéricos , Adolescente , Adulto , Idoso , Causalidade , Comorbidade , Overdose de Drogas , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Polônia/epidemiologia , Propranolol/toxicidade , Verapamil/intoxicação , Adulto Jovem
17.
Pol Merkur Lekarski ; 33(194): 80-5, 2012 Aug.
Artigo em Polonês | MEDLINE | ID: mdl-23009004

RESUMO

UNLABELLED: Streptococcus pneumoniae is a reason of many infectious diseases, from prosy respiratory tract infections to the grave bacterial hematosepsis which often is a cause of patients death. Infection spreads with droplets or sometimes by direct contact. Symptomatic Staphylococcal infections most often unfold as a otitis, sinusitis, broncho-pneumonia and lobal pneumonia or as a chronic obstructive pulmonary disease, bronchial asthma aggravation or they can be the cause of many other illnesses like: meningitis and encephalitis, endocarditis, epicarditis, peritonitis, arthritis and hematosepsis. The aim of the study was to evaluate anti-streptococcal vaccinations and to analyze cardiology patients and General Practitioners patients knowledge about Streptococcus pneumoniae. MATERIAL AND METHODS: There were 312 Cardiology and General Practitioners patient's from Outpatients Clinic in Katowice included to the study. Additionally there were national registers analyzed involving anti-streptococcal vaccination and streptococcal infections data from years from 2006 to 2009. Informations about anti-streptococcal vaccination and data evaluating knowledge about streptococcal infections problems were obtained from the poll made especially for this study. RESULTS: Results of the study showed, that patient's knowledge about anti-streptococcal vaccination is very poor. From 312 patients included to the study only 16 were vaccinated and 118 persons had no knowledge about Streptococus pneumoniae. Data from the national registers showed, that in the years 2006-2009 the invasive form of streptococcal infection had similar number of patients - 273 and 274 respectively - in Silesia, 28 and 26 patients respectively. CONCLUSIONS: The knowledge about anti-streptococcal vaccinations is very poor and a number of people vaccinated small. There is the need to provide more information to rise the number of vaccinated persons, especially in the group of increased risk and consequently reduce worker absenteeism in the work and financial loss.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Infecções Respiratórias/prevenção & controle , Infecções Estreptocócicas/prevenção & controle , Vacinas Estreptocócicas , Adolescente , Adulto , Idoso , Cardiologia/estatística & dados numéricos , Feminino , Medicina Geral/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Polônia , Adulto Jovem
18.
Artigo em Inglês | MEDLINE | ID: mdl-35681946

RESUMO

"Coronary prone behaviour pattern" refers to a way of coping with environmental stressors, otherwise known as type A behaviour patterns. Stress, unlimited working hours, and the shift system are conducive to an "unhealthy life style", conducted by nurses. The aim of the study was to assess the "coronary prone behaviour pattern", taking into account health behaviour and work performed by Polish nurses. Method: This was a descriptive study conducted from June 2017 to May 2018 among nurses (N = 1080) working primary care or in training facilities in Silesia, Poland. Data were acquired through a series of questionnaires and are presented as descriptive statistics. Results: The "coronary prone behaviour pattern" (type A behaviour) was manifested by 333 (30.8%) nurses, type B by 272 (25.2%). The "coronary prone behaviour pattern" respondents showed a risk of developing a problem with alcohol (p = 0.003) less frequently compared with other respondents. In addition, nurses with the abovementioned behaviour pattern ate better (M = 16.66; SD = 6.11) compared with those with the type B behaviour pattern (M = 15.49; SD = 6.52). In terms of mental and physical wellbeing, people with type A behavioural patterns had significantly (p < 0.001) better mental and physical wellbeing and, on average, better results in coping with stress compared with other behavioural patterns of nurses. Conclusion: The occurrence of the "coronary prone behaviour pattern" was associated with the health-promoting behaviours of nurses being the subject of the analysis, i.e., better mental and physical wellbeing, better ability to cope with stress, and a lower risk of problems with alcohol and proper nutrition.


Assuntos
Enfermeiras e Enfermeiros , Personalidade Tipo A , Comportamentos Relacionados com a Saúde , Humanos , Estilo de Vida , Polônia , Inquéritos e Questionários
19.
Artigo em Inglês | MEDLINE | ID: mdl-35162668

RESUMO

The aim of the study was to determine the personality traits, strategies of coping with stress and psychophysical wellbeing of surgical and non-surgical Polish doctors. The study used the following questionnaires and scales: the Resiliency Assessment Scale, the Type D Personality Scale, the Framingham Type A Scale, the Mini COPE-Coping Inventory and the Wellbeing Scale. Doctors performing surgical specialties were characterized by a significantly higher level of resilience components, a more frequent occurrence of the type B behaviour pattern and less frequent type D personality than doctors performing non-surgical specializations. The Mini COPE point values were comparable between surgical and non-surgical physicians. The sense of psychological wellbeing was higher in surgical specialists. The higher the values of the Optimistic approach to life and the ability to mobilize oneself in difficult situations, the lower the values of the Turning to religion domain and the higher the values of the Denial domain correlated with the performance of surgical specialization. Men performing surgical specializations were more often optimistic and inclined to consume alcohol, while women with non-surgical specialization more often coped with stress by turning to religion. We conclude that the personality traits of Polish doctors vary depending on their specialization. Physicians' coping strategies do not differ depending on their specialization. The sense of mental wellbeing is higher in surgical specialists compared to non-surgical specialists. An optimistic approach to life and the ability to mobilize oneself in difficult situations, as well as coping with stress by denial are associated with the surgical specialization. Men performing surgical specialties more often declare optimism and a tendency to cope with stress by consuming alcohol or psychoactive substances, while women who perform non-surgical specializations more often cope with stress by turning to religion. Psychological screening tests and appropriate training, taking into account medical specialization, could be one way of improving resilience and coping with stress among doctors.


Assuntos
Adaptação Psicológica , Médicos , Feminino , Humanos , Masculino , Personalidade , Médicos/psicologia , Polônia , Estresse Psicológico/psicologia , Inquéritos e Questionários
20.
Artigo em Inglês | MEDLINE | ID: mdl-35742539

RESUMO

Cardiovascular diseases are the most common causes of death, in both Poland and the world. Their development and progression are largely influenced by the lifestyle with the presence/occurrence of classic, modifiable risk factors. Among them, low physical activity plays a significant role. The aim of the study was to evaluate the expression of the endothelin-1 gene and its type A receptor, taking into account physical activity (International Physical Activity Questionnaire-IPAQ) among patients with acute myocardial infarction. A total of 234 patients with acute myocardial infarction were examined, including 167 patients undergoing early post-hospital cardiac rehabilitation and 67 not participating in it. All of them were assessed with the IPAQ questionnaire and the quantitative real-time polymerase reaction method (QRT-PCR). Physical activity in the group of patients after early post-hospital cardiac rehabilitation increased after rehabilitation. Transcriptional activity of the endothelin-1 (ET-1) gene in both studied group of patients increased significantly, but in a group of patients not participating in early post-hospital cardiac rehabilitation more than in a group of patients participating in it. In our study, the expression of ET-1 was also significantly higher in the group of patients with acute myocardial infarction with ST-segment elevation, without diabetes, with lipid disorders, smoking, with normal body weight. Expression of the ENDRA (Endothelin receptor A) gene increased with age. These results prove the beneficial effect of rehabilitation and may indicate another pathomechanism of pro-atherogenic activity of above-mentioned factors.


Assuntos
Reabilitação Cardíaca , Infarto do Miocárdio , Reabilitação Cardíaca/métodos , Endotelina-1/genética , Exercício Físico , Humanos , Infarto do Miocárdio/genética , Infarto do Miocárdio/reabilitação , Fatores de Tempo
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