Detalhe da pesquisa
1.
Immunogenicity of avelumab in patients with metastatic Merkel cell carcinoma or advanced urothelial carcinoma.
Clin Transl Sci
; 17(3): e13730, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38411318
2.
Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
Drug Metab Dispos
; 40(11): 2143-61, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22896728
3.
The pharmacokinetics and pharmacodynamics of PF-00734200, a DPP-IV inhibitor, in healthy Japanese subjects.
Int J Clin Pharmacol Ther
; 50(7): 505-9, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22541754
4.
Avelumab Dose Selection for Clinical Studies in Pediatric Patients with Solid Tumors.
Clin Pharmacokinet
; 61(7): 985-995, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35484319
5.
Model-informed drug development supporting the approval of the avelumab flat-dose regimen in patients with advanced renal cell carcinoma.
CPT Pharmacometrics Syst Pharmacol
; 11(4): 458-468, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35166465
6.
Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab.
Clin Cancer Res
; 28(7): 1363-1371, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34921021
7.
Pharmacometric modeling and machine learning analyses of prognostic and predictive factors in the JAVELIN Gastric 100 phase III trial of avelumab.
CPT Pharmacometrics Syst Pharmacol
; 11(3): 333-347, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34971492
8.
The pharmacokinetics of PF-734200, a DPP-IV inhibitor, in subjects with renal insufficiency.
Br J Clin Pharmacol
; 72(1): 85-91, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21366665
9.
Characterizing Exposure-Response Relationship for Therapeutic Monoclonal Antibodies in Immuno-Oncology and Beyond: Challenges, Perspectives, and Prospects.
Clin Pharmacol Ther
; 108(6): 1156-1170, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32557643
10.
Changing Body Weight-Based Dosing to a Flat Dose for Avelumab in Metastatic Merkel Cell and Advanced Urothelial Carcinoma.
Clin Pharmacol Ther
; 107(3): 588-596, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31553054
11.
Evaluation of the potential for QTc prolongation with avelumab.
Cancer Chemother Pharmacol
; 84(5): 1017-1026, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31478078
12.
Time-Varying Clearance and Impact of Disease State on the Pharmacokinetics of Avelumab in Merkel Cell Carcinoma and Urothelial Carcinoma.
CPT Pharmacometrics Syst Pharmacol
; 8(6): 415-427, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30980481
13.
Measurement of drug release from microcarriers by microdialysis.
J Pharm Sci
; 94(7): 1456-66, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15920767
14.
Drug efflux transporters in the CNS.
Adv Drug Deliv Rev
; 55(1): 83-105, 2003 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12535575
15.
Effects of multiple doses of the DPP-IV inhibitor PF-734200 on the relationship between GLP-1 and glucose in subjects with type 2 diabetes mellitus.
Diabetes Res Clin Pract
; 91(2): e45-9, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21130513
16.
Pharmacokinetics, pharmacodynamics, tolerability, and safety of a novel sorbitol dehydrogenase inhibitor in healthy participants.
J Clin Pharmacol
; 50(5): 521-30, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20220044
17.
Drug transport studies using quantitative microdialysis.
Methods Mol Med
; 89: 249-64, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12958425
18.
Distribution of the novel antifolate pemetrexed to the brain.
J Pharmacol Exp Ther
; 315(1): 222-9, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15987831
19.
Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux.
J Pharmacol Exp Ther
; 304(3): 1085-92, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12604685