Detalhe da pesquisa
1.
Pharmacologic activation of estrogen receptor ß increases mitochondrial function, energy expenditure, and brown adipose tissue.
FASEB J
; 31(1): 266-281, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27733447
2.
The long and winding road for selective androgen receptor modulators.
Br J Clin Pharmacol
; 83(10): 2131-2133, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28621446
3.
Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024(Enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin.
Invest New Drugs
; 34(4): 458-67, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27105861
4.
Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials).
Curr Oncol Rep
; 18(6): 37, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27138015
5.
Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial.
Lancet Oncol
; 14(4): 335-45, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23499390
6.
Role and pharmacologic significance of cytochrome P-450 2D6 in oxidative metabolism of toremifene and tamoxifen.
Int J Cancer
; 132(6): 1475-85, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22915089
7.
Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies.
Annu Rev Med
; 62: 265-79, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-20731602
8.
Role of nuclear receptors in lipid dysfunction and obesity-related diseases.
Drug Metab Dispos
; 41(1): 1-11, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23043185
9.
Absorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide] in rats.
Xenobiotica
; 43(11): 993-1009, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24074268
10.
Alanine aminotransferase regulation by androgens in non-hepatic tissues.
Pharm Res
; 29(4): 1046-56, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22167351
11.
Novel tubulin polymerization inhibitors overcome multidrug resistance and reduce melanoma lung metastasis.
Pharm Res
; 29(11): 3040-52, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22410804
12.
Orally bioavailable tubulin antagonists for paclitaxel-refractory cancer.
Pharm Res
; 29(11): 3053-63, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22760659
13.
Estrogen receptor-{beta}-selective ligands alleviate high-fat diet- and ovariectomy-induced obesity in mice.
J Biol Chem
; 285(41): 31292-303, 2010 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20657011
14.
Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia.
Blood
; 113(12): 2637-45, 2009 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-18981292
15.
Pharmacokinetic optimization of 4-substituted methoxybenzoyl-aryl-thiazole and 2-aryl-4-benzoyl-imidazole for improving oral bioavailability.
Drug Metab Dispos
; 39(10): 1833-9, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21742898
16.
Biotransformation of a novel antimitotic agent, I-387, by mouse, rat, dog, monkey, and human liver microsomes and in vivo pharmacokinetics in mice.
Drug Metab Dispos
; 39(4): 636-43, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21233217
17.
Cancer cachexia therapy: a key weapon in the fight against cancer.
Curr Opin Clin Nutr Metab Care
; 14(3): 268-73, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21415732
18.
Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls.
Rapid Commun Mass Spectrom
; 25(15): 2187-95, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21710598
19.
Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization.
Bioorg Med Chem
; 19(16): 4782-95, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21775150
20.
Drug interaction potential of toremifene and N-desmethyltoremifene with multiple cytochrome P450 isoforms.
Xenobiotica
; 41(10): 851-62, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21726172