Detalhe da pesquisa
1.
Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite-binding site.
J Biol Chem
; 298(5): 101852, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35331736
2.
AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR.
FASEB J
; 33(11): 12374-12391, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31404503
3.
Structural basis for the recruitment of glycogen synthase by glycogenin.
Proc Natl Acad Sci U S A
; 111(28): E2831-40, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24982189
4.
Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle.
Am J Physiol Endocrinol Metab
; 311(4): E706-E719, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27577855
5.
Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts.
J Nat Prod
; 79(11): 2856-2864, 2016 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27792327
6.
Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.
Biochem J
; 469(3): 409-20, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26205494
7.
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.
Hum Mol Genet
; 22(2): 328-44, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23065705
8.
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.
EMBO J
; 30(9): 1730-41, 2011 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21423148
9.
Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1ßMYPT1 phosphatase complex and the SCFßTrCP E3 ubiquitin ligase.
Biochem J
; 461(2): 233-45, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24785407
10.
The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.
Biochem J
; 458(3): 559-73, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24393035
11.
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.
Am J Physiol Endocrinol Metab
; 306(6): E688-96, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24425763
12.
Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.
J Cell Sci
; 124(Pt 5): 789-800, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21321328
13.
SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.
Biochem J
; 441(1): 325-37, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22032326
14.
Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry.
J Cell Sci
; 123(Pt 18): 3084-93, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20736304
15.
The Dac-tag, an affinity tag based on penicillin-binding protein 5.
Anal Biochem
; 428(1): 64-72, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22705378
16.
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.
J Cell Biol
; 176(1): 89-100, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17190791
17.
ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.
PLoS Biol
; 7(6): e1000126, 2009 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19513107
18.
Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells.
J Immunol
; 185(10): 5973-82, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20944007
19.
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.
Biochem J
; 437(1): 157-67, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21548880
20.
A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle.
iScience
; 25(7): 104589, 2022 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35789856