Toward an electrophysiological "sweet spot" for deep brain stimulation in the subthalamic nucleus.

Enhanced beta-band activity recorded in patients suffering from Parkinson's Disease (PD) has been described as a potential physiomarker for disease severity. Beta power is suppressed by Levodopa intake and STN deep brain stimulation (DBS) and correlates with disease severity across patients. The aim of the present study was to explore the promising signature of the physiomarker in the spatial domain. Based on local field potential data acquired from 54 patients undergoing STN-DBS, power values within alpha, beta, low beta, and high beta bands were calculated. Values were projected into common stereotactic space after DBS lead localization. Recorded beta power values were significantly higher at posterior and dorsal lead positions, as well as in active compared with inactive pairs. The peak of activity in the beta band was situated within the sensorimotor functional zone of the nucleus. In contrast, higher alpha activity was found in a more ventromedial region, potentially corresponding to associative or premotor functional zones of the STN. Beta- and alpha-power peaks were then used as seeds in a fiber tracking experiment. Here, the beta-site received more input from primary motor cortex whereas the alpha-site was more strongly connected to premotor and prefrontal areas. The results summarize predominant spatial locations of frequency signatures recorded in STN-DBS patients in a probabilistic fashion. The site of predominant beta-activity may serve as an electrophysiologically determined target for optimal outcome in STN-DBS for PD in the future. Hum Brain Mapp 38:3377-3390, 2017. © 2017 Wiley Periodicals, Inc.

Assessment of cortical bone thickness using ultrasound.

PURPOSE: The aim of the study was to analyze the accuracy of measuring the cortical bone thickness using a combination of low- and high-frequency ultrasound (US) compared with cone-beam computed tomography (CBCT) and using stereomicroscopy as reference method. MATERIAL AND METHODS: Ten jawbone models were prepared using bovine ribs and porcine gingiva. A dental implant was placed in each model. All models were investigated by US, CBCT, and stereomicroscopy. The cortical bone thickness was measured directly above and 4 mm beside the implant with each method in different slices. RESULTS: The median deviation of US measurements compared to the reference method was 0.23 mm. The CBCT method was slightly more accurate (median percent deviation of 9.2%) than the US method (10.3%). However, US measurements directly above the implant were more accurate than CBCT measurements with a median percent deviation of 10.5% for US vs. 11.8% for CBCT. CONCLUSION: Ultrasound showed a high potential to supplement CBCT for measurements of the cortical bone thickness.

Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson's disease.

OBJECTIVE: Beta band oscillations in the subthalamic nucleus (STN) have been proposed as a pathophysiological signature in patients with Parkinson's disease (PD). The aim of this study was to investigate the potential association between oscillatory activity in the STN and symptom severity in PD. METHODS: Subthalamic local field potentials were recorded from 63 PD patients in a dopaminergic OFF state. Power-spectra were analyzed for the frequency range from 5 to 95 Hz and correlated with individual UPDRS-III motor scores in the OFF state. RESULTS: A correlation between total UPDRS-III scores and 8 to 35 Hz activity was revealed across all patients (ρ = 0.44, P < .0001). When correlating each frequency bin, a narrow range from 10 to 15 Hz remained significant for the correlation (false discovery rate corrected P < .05). CONCLUSION: Our results show a correlation between local STN 8 to 35 Hz power and impairment in PD, further supporting the role of subthalamic oscillatory activity as a potential biomarker for PD.