Detalhe da pesquisa
1.
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction.
Cell
; 144(2): 282-95, 2011 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21241895
2.
Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors.
J Neurosci
; 38(47): 10180-10201, 2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30301756
3.
Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease.
Neurobiol Dis
; 74: 254-62, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25484285
4.
RIM genes differentially contribute to organizing presynaptic release sites.
Proc Natl Acad Sci U S A
; 109(29): 11830-5, 2012 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22753485
5.
Histone deacetylase 2 cell autonomously suppresses excitatory and enhances inhibitory synaptic function in CA1 pyramidal neurons.
J Neurosci
; 33(14): 5924-9, 2013 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23554474
6.
Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife
; 122023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36975198
7.
Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids.
Neuron
; 111(17): 2642-2659.e13, 2023 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37352856
8.
RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions.
J Neurosci
; 28(50): 13435-47, 2008 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19074017
9.
Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.
J Med Chem
; 62(8): 4091-4109, 2019 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30943032
10.
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.
J Med Chem
; 62(2): 908-927, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30499663
11.
Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures.
J Neurosci
; 27(40): 10860-9, 2007 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17913919
12.
GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses.
J Neurosci
; 26(49): 12758-68, 2006 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17151279
13.
A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain.
Neuropharmacology
; 121: 204-218, 2017 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28457974
14.
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
Science
; 350(6267): aac5464, 2015 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26680203
15.
GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior.
Neuropsychopharmacology
; 38(7): 1221-33, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23340518
16.
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13.
Neuron
; 69(2): 317-31, 2011 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21262469
17.
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.
Neuron
; 64(2): 227-39, 2009 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-19874790
18.
Cyclothiazide potently inhibits gamma-aminobutyric acid type A receptors in addition to enhancing glutamate responses.
Proc Natl Acad Sci U S A
; 100(22): 13025-9, 2003 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-14534329
19.
Hyperpolarization-activated, cyclic nucleotide-gated cation channels: roles in the differential electrophysiological properties of rat primary afferent neurons.
J Neurosci Res
; 76(5): 713-22, 2004 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15139030
20.
Formation of an endophilin-Ca2+ channel complex is critical for clathrin-mediated synaptic vesicle endocytosis.
Cell
; 115(1): 37-48, 2003 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-14532001