Detalhe da pesquisa
1.
Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1.
Biochemistry
; 60(43): 3262-3271, 2021 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34662099
2.
Midazolam as a Probe for Drug-Drug Interactions Mediated by CYP3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation.
Biochemistry
; 60(21): 1670-1681, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34015213
3.
Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5.
J Am Chem Soc
; 143(10): 3729-3733, 2021 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33656879
4.
P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency.
Chemistry
; 26(70): 16846-16852, 2020 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32681807
5.
Dark, Ultra-Dark and Ultra-Bright Nanodiscs for membrane protein investigations.
Anal Biochem
; 607: 113860, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32750355
6.
Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213.
Biochemistry
; 58(10): 1411-1422, 2019 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30785734
7.
Nanodiscs in Membrane Biochemistry and Biophysics.
Chem Rev
; 117(6): 4669-4713, 2017 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28177242
8.
Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4.
Biochemistry
; 57(5): 805-816, 2018 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29200287
9.
Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone.
J Am Chem Soc
; 140(23): 7324-7331, 2018 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29758981
10.
Spectroscopic studies of the cytochrome P450 reaction mechanisms.
Biochim Biophys Acta Proteins Proteom
; 1866(1): 178-204, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-28668640
11.
Unveiling the crucial intermediates in androgen production.
Proc Natl Acad Sci U S A
; 112(52): 15856-61, 2015 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26668369
12.
Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis.
Biochem Biophys Res Commun
; 477(2): 202-8, 2016 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27297105
13.
Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomer.
Biochemistry
; 54(13): 2227-39, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25777547
14.
Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 12): 2412-21, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627649
15.
Correction to "Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213".
Biochemistry
; 58(24): 2796, 2019 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31181900
16.
Active site proton delivery and the lyase activity of human CYP17A1.
Biochem Biophys Res Commun
; 443(1): 179-84, 2014 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24299954
17.
Nanodiscs for the study of membrane proteins.
Curr Opin Struct Biol
; 87: 102844, 2024 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38795563
18.
Cryoradiolysis of oxygenated cytochrome P450 17A1 with lyase substrates generates expected products.
J Inorg Biochem
; 257: 112582, 2024 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38723329
19.
Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate.
J Am Chem Soc
; 135(44): 16245-7, 2013 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24160919
20.
Oxidase uncoupling in heme monooxygenases: human cytochrome P450 CYP3A4 in Nanodiscs.
Biochem Biophys Res Commun
; 430(4): 1223-7, 2013 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23266608