RESUMO
Improvements to contrast media formulations may be an effective way to increase the accuracy and effectiveness of thoracic computed tomography (CT) imaging in disease evaluation. To achieve contrast enhancement in the lungs, a relatively large localized concentration of contrast media must be delivered. Inhalation offers a noninvasive alternative to intrapleural injections for local lung delivery, but effective aerosolization may deter successful imaging strategies. Here, NanoCluster technology was applied to N1177, a diatrizoic acid derivative, to formulate low density nanoparticle agglomerates with aerodynamic diameters Assuntos
Meios de Contraste/administração & dosagem
, Meios de Contraste/química
, Iodo/química
, Pulmão/diagnóstico por imagem
, Nanoestruturas/administração & dosagem
, Nanoestruturas/química
, Tomografia Computadorizada por Raios X/métodos
, Administração por Inalação
, Animais
, Masculino
, Nanotecnologia/métodos
, Ratos
, Ratos Endogâmicos F344
, Ratos Sprague-Dawley