The effect of different flow levels and concentrations of sevoflurane during the wash-in phase on volatile agent consumption: a randomized controlled trial.

PURPOSE: The standard procedure for low-flow anesthesia usually incorporates a high fresh gas flow (FGF) of 4-6 L/minute during the wash-in phase. However, the administration of a high FGF (4-6 L/min) increases the inhaled anesthetic agent consumption. This study was designed to compare the sevoflurane consumption at 2 rates of flow and vaporizer concentration during the wash-in period. METHODS: Patients were randomly enrolled into high FGF (HFGF) (n = 30) and low FGF (LFGF) (n = 30) groups. During the wash-in, the HFGF group received 4 L/minute FGF with a sevoflurane vaporizer setting of 2.5%, and the LFGF group received 1 L/minute FGF with a vaporizer setting of 8%. Once the wash-in was complete, anesthesia maintenance was performed with 0.5 L/min FGF with a vaporizer setting of 2.5-4.5% in both groups. The patient demographic data, bispectral index values, hemodynamic variables, wash-in time, sevoflurane consumption during the wash-in phase, and total sevoflurane consumption were analyzed. RESULTS: The median sevoflurane consumption in the wash-in phase was 8.2 mL (7.1-9.3) in the HFGF group and 2.7 mL (2.2-3.1) in the LFGF group (p = 0.001). The mean total sevoflurane consumption was 17.41 ± 3.58 mL in the patients who received HFGF and 14.93 ± 3.57 mL in the LFGF group (p = 0.001). The mean wash-in completion time was 12.49 ± 2.79 min in the HFGF group and 3.35 ± 0.67 min in the LFGF group (p = 0.001). CONCLUSIONS: The anesthetic agent consumption during the wash-in phase was approximately 3 times lower with the administration of sevoflurane at 1 L/minute FGF than the use of 4 L/minute FGF.

Global trends and future prospects of COVID-19 and physical activity: Bibliometric analysis.

BACKGROUND: Containment measures implemented during the COVID-19 pandemic have led to drastic changes in daily life and effects on health behaviors such as decrease in physical activity (PA) levels. This study aims to present a general framework to researchers on COVID-19 and PA research in relation with changes in studies within years, current trend topics, gaps in the research field and possible future trends. METHODS: A total of 1819 articles indexed in the WoS core collection database were analyzed according to publication year, citation, country and institution collaborations, coword, co-citation networks, concept-topic trends and topic clusters using bibliometric analysis. RESULTS: The most productive country was the USA(n = 335), and the most productive institution was University of London in UK (n = 38). The most cited publication was the study by Ammar et al, (2020) (n = 188). In 2020, the most popular topics were PA and health meanwhile in 2021 behavior, lifestyle, social media and in 2022 habits, long COVID, sleep quality topics were in the foreground. Studies in 2023 focus on how COVID-19 affects PA habits and the associations between COVID-19-based anxiety and sleep patterns. These studies focused especially on effects of sport participation on life quality, diet, depression, mental health on young athletes, children, adolescent persons, older adult groups. CONCLUSIONS: An important gap in the study area is research on effect of changing lifestyle due to pandemic on individuals and the society during the Post COVID-19 period. If benefits of PA will not be limited to only physical benefits and psychological emotional, cognitive and social benefits are also taken into consideration, it is important that researchers conduct long-term and widescale observations.