Detalhe da pesquisa
1.
Physical 'strength' of the multi-protein chain connecting immune cells: Does the weakest link limit antibody affinity maturation?: The weakest link in the multi-protein chain facilitating antigen acquisition by B cells in germinal centres limits antibody affinity maturation.
Bioessays
; 43(4): e2000159, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33448042
2.
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection.
PLoS Comput Biol
; 16(12): e1008461, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33290397
3.
Early exposure to broadly neutralizing antibodies may trigger a dynamical switch from progressive disease to lasting control of SHIV infection.
PLoS Comput Biol
; 16(8): e1008064, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32817614
4.
Assessing the extent of the structural and dynamic modulation of membrane lipids due to pore forming toxins: insights from molecular dynamics simulations.
Soft Matter
; 16(20): 4840-4857, 2020 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32421131
5.
Opening of smaller toxin pores by lipid micelle formation.
Proc Natl Acad Sci U S A
; 117(10): 5107-5108, 2020 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32098842
6.
Assessing the Structure and Stability of Transmembrane Oligomeric Intermediates of an α-Helical Toxin.
Langmuir
; 33(42): 11496-11510, 2017 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28930630
7.
The Solvent-Exposed C-Terminus of the Cytolysin A Pore-Forming Toxin Directs Pore Formation and Channel Function in Membranes.
Biochemistry
; 55(42): 5952-5961, 2016 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27682503
8.
A Quantitative Clinical Pharmacology-Based Framework For Model-Informed Vaccine Development.
J Pharm Sci
; 113(1): 22-32, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37924975
9.
Modeling how antibody responses may determine the efficacy of COVID-19 vaccines.
Nat Comput Sci
; 2(2): 123-131, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38177523
10.
Modeling suggests that multiple immunizations or infections will reveal the benefits of updating SARS-CoV-2 vaccines.
bioRxiv
; 2022 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35665010
11.
Vaccine models predict rules for updating vaccines against evolving pathogens such as SARS-CoV-2 and influenza in the context of pre-existing immunity.
Front Immunol
; 13: 985478, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36263031
12.
Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics.
Int J Antimicrob Agents
; 60(1): 106606, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35588969
13.
Evaluating Coarse-Grained MARTINI Force-Fields for Capturing the Ripple Phase of Lipid Membranes.
J Phys Chem B
; 125(24): 6587-6599, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34081861
14.
Predicting interfacial hot-spot residues that stabilize protein-protein interfaces in oligomeric membrane-toxin pores through hydrogen bonds and salt bridges.
J Biomol Struct Dyn
; 39(1): 20-34, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31903844
15.
Using multiscale molecular dynamics simulations to obtain insights into pore forming toxin mechanisms.
Methods Enzymol
; 649: 461-502, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33712196
16.
Increased B Cell Selection Stringency In Germinal Centers Can Explain Improved COVID-19 Vaccine Efficacies With Low Dose Prime or Delayed Boost.
Front Immunol
; 12: 776933, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34917089
17.
Application of quantitative systems pharmacology to guide the optimal dosing of COVID-19 vaccines.
CPT Pharmacometrics Syst Pharmacol
; 10(10): 1130-1133, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34331834
18.
Preferential Presentation of High-Affinity Immune Complexes in Germinal Centers Can Explain How Passive Immunization Improves the Humoral Response.
Cell Rep
; 29(12): 3946-3957.e5, 2019 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31851925
19.
CYTOCON DB: A versatile database of human cell and molecule concentrations for accelerating model development.
CPT Pharmacometrics Syst Pharmacol
; 12(1): 5-7, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36633255
20.
Role of pharmacometrics and systems pharmacology in facilitating efficient dose optimization in oncology.
CPT Pharmacometrics Syst Pharmacol
; 12(11): 1569-1572, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37849052