RESUMO
OBJECTIVE: To assess whether adding metoclopramide to a protocol of maropitant and pantoprazole would reduce incidence of ptyalism, vomiting and regurgitation in brachycephalic dogs undergoing thoracolumbar spinal surgery. STUDY DESIGN: Randomized blinded controlled trial. ANIMALS: A total of 43 brachycephalic dogs undergoing thoracolumbar spinal surgery. METHODS: In addition to a standardized anaesthetic regimen, dogs were randomized to be administered either a 2 mg kg-1 day-1 metoclopramide constant rate infusion (CRI) or a saline solution at an equivalent infusion rate, started after anaesthetic induction and discontinued 5 hours after tracheal extubation. The presence of vomiting, regurgitation and pytalism, and short form of the Glasgow Composite Pain Scale pain scores were assessed by a blinded observer hourly for 4 hours, starting 1 hour postextubation. RESULTS: Regurgitation occurred in six dogs postoperatively; three dogs were in the placebo group and three in the metoclopramide group. The odds ratio (OR) of regurgitation after surgery did not differ between groups [OR: 0.76, 95% confidence interval (CI): 0.13-4.3, p = 0.76]. The odds of observing ptyalism at 3 and 4 hours was approximately 15 times less than 1 hour postoperatively (both OR: 15.4, 95% CI: 1.8-130.7, p = 0.012) and did not differ based on the addition of metoclopramide (OR: 0.73, 95% CI: 0.07-8.0, p = 0.79). The odds of observing pain did not change over time and did not differ based on the addition of metoclopramide (OR: 0.71, 95% CI: 0.12-4.2, p = 0.71). Vomiting did not occur during the study (0.0%, 95% CI: 0.0-8.2%). No adverse effects were observed during the study period in either group. CONCLUSIONS AND CLINICAL RELEVANCE: The addition of a metoclopramide CRI to maropitant and pantoprazole did not result in a significant reduction in ptyalism or regurgitation in brachycephalic dogs undergoing thoracolumbar spinal surgery.
Assuntos
Antieméticos , Doenças do Cão , Metoclopramida , Animais , Cães , Metoclopramida/administração & dosagem , Metoclopramida/uso terapêutico , Antieméticos/administração & dosagem , Antieméticos/uso terapêutico , Masculino , Feminino , Doenças do Cão/cirurgia , Doenças do Cão/prevenção & controle , Craniossinostoses/cirurgia , Craniossinostoses/veterinária , Náusea e Vômito Pós-Operatórios/veterinária , Náusea e Vômito Pós-Operatórios/prevenção & controle , Refluxo Laringofaríngeo/veterinária , Refluxo Laringofaríngeo/prevenção & controle , Quinuclidinas/administração & dosagem , Quinuclidinas/uso terapêutico , Pantoprazol/administração & dosagem , Pantoprazol/uso terapêutico , Pantoprazol/farmacologiaRESUMO
Small intestinal obstruction in rabbits, although demonstrated to be common, is still poorly characterized. The objective of this study was to report features of small intestinal obstruction caused by trichobezoars in rabbits upon CT and their clinical outcomes. Rabbits with a diagnosis of intestinal obstruction that underwent CT scanning were included in this study. From each CT scan, obstruction location, appearance, Hounsfield units, size (mm), volume (mm3), distance from the stomach, and diameter of the small intestine proximal and distal to it, were extracted. Nine rabbits were included in the study. All rabbits presented for anorexia and had a distended or enlarged stomach (7) or abdomen (2). CT scan showed a non-contrast-enhancing, ovoid, smoothly marginated structure with a hyperattenuating rim, heterogeneous center, and variable amount of centrally located gas, in the duodenum (5), the jejunum (2), or the ileum (2). The density of the trichobezoars ranged from -156 to 58 HU (median, -44 HU) and volume ranged from 86.1 to 633.8 mm3 (median, 320.6 mm3). Three rabbits underwent medical management. Two of them survived, and one of them died. Six rabbits underwent surgery, of which three were successfully discharged from the hospital. CT proved to be a valuable imaging modality in rabbits with a suspected intestinal obstruction to provide the exact location of the obstruction and the characteristics of the obstructive material. The location and size of the trichobezoar may have relevant clinical implications.
Assuntos
Bezoares , Obstrução Intestinal , Intestino Delgado , Tomografia Computadorizada por Raios X , Animais , Coelhos , Obstrução Intestinal/veterinária , Obstrução Intestinal/diagnóstico por imagem , Obstrução Intestinal/etiologia , Obstrução Intestinal/cirurgia , Bezoares/veterinária , Bezoares/diagnóstico por imagem , Bezoares/complicações , Tomografia Computadorizada por Raios X/veterinária , Feminino , Intestino Delgado/diagnóstico por imagem , MasculinoRESUMO
OBJECTIVE: To compare 5% lidocaine ointment applied for 10 minutes before intravenous (IV) catheterization to a eutectic mixture of local anesthetics (2.5% lidocaine and 2.5% prilocaine; EMLA) cream applied for 10 or 60 minutes prior and a water-based placebo for 60 minutes for successful marginal ear IV catheterization in rabbits. STUDY DESIGN: Randomized, blinded, complete crossover, controlled trial. ANIMALS: A total of 10 intact male, New Zealand White rabbits aged 4 months. METHODS: After application of one of the treatments on the marginal ear vein, an operator unaware of the treatment attempted IV catheter placement. Successful IV catheterization was considered as a catheter inserted at the first attempt, safely secured, with appropriate patency. Generalized linear mixed models were developed to identify relevant predictors of successful catheter placement. RESULTS: Ears that had EMLA cream applied 60 minutes before the catheterization attempt had more than 10 times the odds of successful catheter placement [odds ratio (OR)=10.75; 95% confidence interval (CI), 1.92-60.16; p < 0.008] compared with placebo. Both the application of EMLA cream or lidocaine ointment 10 minutes before the catheterization attempt resulted in approximately three times the odds of successful catheter placement compared with placebo, but were not statistically significant. CONCLUSIONS AND CLINICAL RELEVANCE: Application of EMLA cream on the marginal ear vein 60 minutes before catheterization increases the chance of successful IV catheter placement in conscious rabbits.
Assuntos
Cateterismo Periférico , Prilocaína , Anestésicos Locais , Animais , Cateterismo Periférico/veterinária , Método Duplo-Cego , Lidocaína , Combinação Lidocaína e Prilocaína , Masculino , Pomadas , Coelhos , ÁguaRESUMO
OBJECTIVE: To report the long-term (>1 year) outcome of MicroPulse transscleral diode cyclophotocoagulation (MP-TSCP) in dogs. ANIMALS STUDIED: Client owned dogs that underwent MP-TSCP at a veterinary referral center. PROCEDURE: Retrospective study of 19 dogs treated with MP-TSCP. Dogs were evaluated at a median follow-up time of 30.5 months postoperatively. Reported outcomes were intraocular pressure (IOP), retention or loss of vision, number of medications, and additional procedures performed. Variables associated with time to treatment failure were evaluated. RESULTS: Data from 19 dogs (24 eyes) was available. Median laser settings employed were 140 s and 2200 mW at 31.3% duty cycle. Long-term postoperative IOP was lower than preoperative IOP values (14 mmHg (IQR = 22 mmHg, range: 4-52 mmHg) versus 30 mmHg (IQR = 31 mmHg, range: 8-62 mmHg), respectively). Laser settings >2000 mW were associated with a significantly longer time to reported failure. MP-TSCP was the sole therapy performed in 16/24 eyes resulting in long-term IOP control in 13/24 eyes and retention of vision in 6 of the 14 sighted eyes. Repeat MP-TSCP was performed in 10/24 eyes. Eight of 24 eyes required additional procedures with long-term IOP control in 4/8 eyes. CONCLUSIONS: MicroPulse transscleral diode cyclophotocoagulation can be an effective treatment for refractory glaucoma in select cases. Higher laser settings increased time to reported failure, whereas age, glaucoma type, and preoperative IOP did not affect survival. MP-TSCP as sole therapy or coupled with additional glaucoma procedures controlled the IOP in 70% of cases.
Assuntos
Doenças do Cão , Glaucoma , Animais , Corpo Ciliar , Doenças do Cão/cirurgia , Cães , Glaucoma/cirurgia , Glaucoma/veterinária , Pressão Intraocular , Fotocoagulação a Laser/veterinária , Lasers Semicondutores/uso terapêutico , Estudos Retrospectivos , Esclera/cirurgia , Resultado do TratamentoRESUMO
OBJECTIVE: To evaluate if intramuscular (IM) lidocaine potentiates the sedative effects of alfaxalone and results in cardiopulmonary changes in sedated bearded dragons. STUDY DESIGN: Prospective experimental crossover study. ANIMALS: A group of eight adult bearded dragons (Pogona vitticeps) weighing 334 ± 46 g. METHODS: Animals were administered alfaxalone (10 mg kg-1 subcutaneously) and 15 minutes later either lidocaine 2% (4 mg kg-1) or 0.9% sodium chloride (0.2 mL kg-1) was administered IM in the thoracic limb. The treatments were randomized and separated by 7 days. Sedation was scored based on body position, eye closure, jaw tone, swallowing, pick up response, righting reflex and pelvic limb withdrawal reflex. Heart rate (HR) and respiratory rate (fR) were recorded every 5 minutes until recovery from sedation. RESULTS: Lidocaine had no significant effect on duration or depth of alfaxalone sedation. HR increased significantly for <10 minutes following lidocaine administration by a median (interquartile range) of 33% (28-37%; p = 0.024). No clinically significant effects on fR occurred following lidocaine injection. CONCLUSIONS AND CLINICAL RELEVANCE: Administration of lidocaine 2% (4 mg kg-1) IM did not potentiate alfaxalone sedation but resulted in a transient clinically relevant increase in HR.
Assuntos
Anestésicos Locais/farmacologia , Anestésicos/farmacologia , Lidocaína/farmacologia , Lagartos , Pregnanodionas/farmacologia , Anestésicos/administração & dosagem , Anestésicos Locais/administração & dosagem , Animais , Estudos Cross-Over , Feminino , Injeções Intramusculares , Lidocaína/administração & dosagem , Masculino , Pregnanodionas/administração & dosagem , Distribuição AleatóriaRESUMO
OBJECTIVE: To describe the prevalence and the types of eye disorders that are known or presumed to be inherited (KP-HED) in three small Italian dog breeds. ANIMALS: Three small Italian dog breeds: Maltese, Bolognese, and Italian Greyhound. PROCEDURES: All dogs of the breeds selected for this prospective observational study that underwent a complete ophthalmic examination between 1994 and 2015 were included. General and proportional KP-HED prevalence with 95% confidence intervals were reported. RESULTS: Three hundred and six of 462 dogs were affected by at least one KP-HED (66.2%; 95% CI: 61.8%-70.4%). In the entire population, the five most common KP-HED were cataract (n = 122; rate on the total number of KP-HED: 31.4%), entropion (n = 56; 14.4%), keratoconjunctivitis sicca (n = 33; 8.5%), retinal dysplasia (n = 24; 6.2%), and persistent pupillary membrane (iris to iris) (n = 21; 5.4%). The most common KP-HED in each breed were cataracts in the Maltese (35.1%) and in the Bolognese (24.2%), and presentation of vitreous in the anterior chamber in the Italian Greyhound (46.7%). CONCLUSIONS: Clinicians should be aware of KP-HED that commonly affect three small Italian dog breeds. Breed standards should be reconsidered, and breeding programs should be directed at limiting such disorders.
Assuntos
Doenças do Cão/epidemiologia , Oftalmopatias/veterinária , Predisposição Genética para Doença , Animais , Cruzamento , Catarata/epidemiologia , Catarata/veterinária , Doenças do Cão/genética , Cães , Oftalmopatias/epidemiologia , Feminino , Glaucoma/epidemiologia , Glaucoma/veterinária , Itália/epidemiologia , Masculino , Estudos ProspectivosRESUMO
Indian flying foxes ( Pteropus giganteus) are adapted to visual foraging in dim light. Nine Indian flying foxes were taken from a captive colony of 25 animals and placed in quarantine, off exhibit, in preparation for shipment to another institution. The exhibit had indirect, natural sunlight and was large enough to allow for flight. The quarantine enclosure was subject to >12 hr/day artificial lighting and did not allow for flight or gliding. Diet was identical between groups. After 13 mo, ophthalmic examination was performed on each animal including evaluation of the anterior chamber, rebound tonometry in upright and hanging positions, measurement of palpebral fissure length, and vertical and horizontal corneal diameters. Bilateral cataracts were observed in 55% (5/9) of the quarantined animals but in none of the animals that remained on exhibit (0/16). Bats housed in the quarantine enclosure had a risk of having cataracts 18 times greater than did bats in the exhibit enclosure (relative risk [RR]: 18.70; 95% confidence interval [CI]: 1.15-303.77). There was no association between cataract presence and age (odds ratio [OR]: 0.99; 95% CI: 0.97-1.02; P = 0.7) or sex (OR: 1.24; 95% CI: 0.17-9.25), but lower body weight was associated with presence of cataracts (OR: 0.98; 95% CI: 0.96-0.99). Other ophthalmic parameters observed were similar to those previously reported for other captive Megachiroptera. This study suggests that chronic exposure to artificial lighting predisposes fruit bats to developing light-induced cataracts.
Assuntos
Catarata/veterinária , Quirópteros , Iluminação/efeitos adversos , Animais , Animais de Zoológico , Catarata/etiologia , Feminino , Abrigo para Animais , Masculino , Fatores de Risco , Tonometria OcularRESUMO
OBJECTIVE: To evaluate effectiveness and safety of debulking and diode laser photocoagulation (DPC) for the treatment of limbal melanoma (LM). PROCEDURE: Retrospective multi-institutional case series. Medical records of animals diagnosed with LM at the Centro Veterinario Specialistico (CVS) and at the Long Island Veterinary Specialists from 1994 to 2014 were retrieved. Signalment, location, extent of tumors, recurrence rate, and early and late complications were reported. Patient follow-up information was obtained from veterinary ophthalmologists, primary care veterinarians, and where appropriate, owners. RESULTS: Twenty-one eyes of 21 dogs (13 females and 8 males) were included in this study. The dogs' average age was 6 years (range: 7 months-11 years). The follow-up period ranged from 1-108 months (median 48 months) after the last DPC procedure. Long-term follow-up was obtained by telephone interviews in 6 of 20 cases and by clinical re-evaluations in 14 of 20 cases. The most common early complications were a moderate anterior uveitis and peripheral corneal edema (21/21 eyes). Late complications included corneal fibrosis and/or pigmentation (20/21). In one case, a severe bullous keratopathy associated with extensive corneal fibrosis was observed (1/21). One case was blind due to concurrent Sudden Acquired Retinal Degeneration (SARD). However, after surgery 2 of 20 eyes lost vision and one of these was enucleated. CONCLUSIONS: Debulking, in addition to diode laser photocoagulation, was technically straightforward to perform, minimally invasive, well tolerated, and highly successful in this case series.
Assuntos
Cirurgia da Córnea a Laser/veterinária , Procedimentos Cirúrgicos de Citorredução/veterinária , Doenças do Cão/cirurgia , Neoplasias Oculares/veterinária , Fotocoagulação a Laser/veterinária , Limbo da Córnea/cirurgia , Melanoma/veterinária , Animais , Coagulação com Plasma de Argônio , Terapia Combinada , Cães , Neoplasias Oculares/cirurgia , Feminino , Lasers Semicondutores , Masculino , Melanoma/cirurgia , Estudos RetrospectivosRESUMO
OBJECTIVE: To describe the epidemiology and the types of eye disorders that are presumed to be inherited (PIED) in three large Italian dog breeds. ANIMALS: Three large Italian dog breeds: Neapolitan Mastiff (FCI code: 197), Maremma Sheepdog (FCI code: 201), and Italian Corso dog (FCI code: 343). PROCEDURES: All dogs that underwent a complete ophthalmic examination between 1992 and 2012 were included in this prospective observational study. The prevalence of eye disorders with 95% confidence intervals was reported for presumed healthy dogs and for dogs referred to a veterinary center for an ophthalmic consultation. Univariate and multivariate logistic regression techniques were used to generate odds ratios. RESULTS: Of 605 dogs examined during the study period, 351 dogs were affected by at least one PIED (58%; 95% CI: 54-62%). The prevalence of PIED was significantly lower in dogs presented for ophthalmic examination (53.8%) as compared to presumed healthy dogs (62.2%)(OR: 1.4; 95% CI: 1.02-1.9; P = 0.037). Also after multivariate adjustment for the period of observation, the odds of Neapolitan Mastiff (92.1%; OR: 21.4; 95% CI: 11.1-41.4) and of Cane Corso (57.7%; OR: 2.5; 95% CI: 1.7-3.6) suffering a PIED were greater than the Maremma Sheepdog (35.4%). The most common PIED in each breed were entropion (24.3% of all the PIED) in the Neapolitan Mastiff, ectropion (36.6%) in the Corso dog, and cataract (27.9%) in the Maremma Sheepdog. CONCLUSIONS: Clinicians should be aware that three large Italian dog breeds frequently suffer PIED. Breed standards should be reconsidered, and breeding programs should be directed at limiting such disorders.
Assuntos
Doenças do Cão/epidemiologia , Oftalmopatias/veterinária , Animais , Catarata/epidemiologia , Catarata/genética , Catarata/veterinária , Doenças do Cão/genética , Cães , Oftalmopatias/epidemiologia , Oftalmopatias/genética , Itália/epidemiologia , Estudos Prospectivos , Especificidade da EspécieRESUMO
The objective of this prospective, blinded study was to compare plasma biochemical values and gross and histologic evaluation of kidney and liver from American alligators ( Alligator mississippiensis ) fed extruded diets with protein derived from animal or plant sources. Alligators in two treatment groups were fed an extruded diet with protein derived primarily from plant products for 7 (n = 20) or 10 (n = 20) mo prior to harvest. A control group (n = 20) was fed a commercial diet with protein derived from animal products for the duration of the study. Plasma biochemistry panels were obtained and gross and histologic examination of kidney and liver tissues was conducted for each animal. No differences were found between alligators fed diets with animal or plant protein in terms of either biochemistry profiles or gross or histologic examination of kidney and liver. Plant-based diets, fed for up to 10 mo, do not appear to have any ill effects on the kidney or liver of American alligators.
Assuntos
Jacarés e Crocodilos , Ração Animal/análise , Proteínas Alimentares/farmacologia , Proteínas de Plantas/farmacologia , Criação de Animais Domésticos , Fenômenos Fisiológicos da Nutrição Animal , Animais , Dieta/veterináriaRESUMO
BACKGROUND: Contrast-enhanced diagnostic imaging techniques are considered useful in veterinary and human medicine to evaluate liver perfusion and focal hepatic lesions. Although hepatic diseases are a common occurrence in reptile medicine, there is no reference to the use of contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) to evaluate the liver in lizards. Therefore, the aim of this study was to evaluate the pattern of change in echogenicity and attenuation of the liver in green iguanas (Iguana iguana) after administration of specific contrast media. RESULTS: An increase in liver echogenicity and density was evident during CEUS and CECT, respectively. In CEUS, the mean ± SD (median; range) peak enhancement was 19.9% ± 7.5 (18.3; 11.7-34.6). Time to peak enhancement was 134.0 ± 125.1 (68.4; 59.6-364.5) seconds. During CECT, first visualization of the contrast medium was at 3.6 ± 0.5 (4; 3-4) seconds in the aorta, 10.7 ± 2.2 (10.5; 7-14) seconds in the hepatic arteries, and 15 ± 4.5 (14.5; 10-24) seconds in the liver parenchyma. Time to peak was 14.1 ± 3.4 (13; 11-21) and 31 ± 9.6 (29; 23-45) seconds in the aorta and the liver parenchyma, respectively. CONCLUSION: CEUS and dynamic CECT are practical means to determine liver hemodynamics in green iguanas. Distribution of contrast medium in iguana differed from mammals. Specific reference ranges of hepatic perfusion for diagnostic evaluation of the liver in iguanas are necessary since the use of mammalian references may lead the clinician to formulate incorrect diagnostic suspicions.
Assuntos
Meios de Contraste/farmacologia , Iguanas/anatomia & histologia , Fígado/irrigação sanguínea , Fígado/fisiologia , Tomografia Computadorizada por Raios X/veterinária , Ultrassonografia/veterinária , Anestesia Geral/veterinária , Animais , Feminino , Masculino , Tomografia Computadorizada por Raios X/métodos , Ultrassonografia/métodosRESUMO
BACKGROUND: A novel bivalent vaccine to protect against myxomatosis and rabbit haemorrhagic disease is commercially available for pet rabbits. HYPOTHESIS/OBJECTIVES: To describe the appearance of cutaneous lesions arising in pet rabbits positive for myxoma virus (MV) by RT-PCR evaluation shortly after vaccination. ANIMALS: Four pet rabbits presenting with papular, crusting skin lesions ~10 days after vaccination. METHODS: Histological evaluation of formalin-fixed skin biopsies obtained from lesional skin (case 1). Real-time polymerase chain reaction (RT-PCR) evaluation of paraffin-embedded tissue from skin biopsies (case 1) and crusts obtained from the lesion surface (cases 2-4) for myxoma virus are reported as cycle threshold (Ct ) values. RESULTS: Lesions affecting the ear pinna, dorsal aspect of the nose, vulva and/or conjunctiva are reported. Histopathological findings included severe ulcerative, necrotizing dermatitis and intralesional cytoplasmic inclusion bodies in myxoma cells. DNA was amplified from all the paraffin-embedded skin biopsies (Ct = 34-35) and crusts (Ct = 20-24). CONCLUSIONS AND CLINICAL IMPORTANCE: Although a wild virus challenge cannot be definitively excluded, veterinarians and pet-owners should be aware that cutaneous lesions have been observed after vaccination with this novel vaccine in low numbers of rabbits.
Assuntos
Infecções por Caliciviridae/veterinária , Vírus da Doença Hemorrágica de Coelhos/imunologia , Myxoma virus/imunologia , Mixomatose Infecciosa/prevenção & controle , Coelhos , Dermatopatias/veterinária , Vacinas Virais/efeitos adversos , Animais , Infecções por Caliciviridae/prevenção & controle , Feminino , Coelhos/virologia , Dermatopatias/etiologiaRESUMO
A great white pelican (Pelecanus onocrotalus) was referred for assessment of a subacute-onset, nonpainful swelling located in the pectoral region. Physical examination revealed a firm, round, well-circumscribed subcutaneous mass approximately 10 cm in diameter. Cytological evaluation of a fine needle aspirate of the mass was consistent with a mesenchymal tumor. The mass was excised, and a diagnosis of xanthomatosis was made based on histopathologic results. Avian xanthomatosis is a nonneoplastic condition of unknown etiology. Possible causes of this condition include trauma, metabolic or nutritional disorders. Similar lesions were not observed in the nine conspecifics that were fed the same diet and housed in the same enclosure. To our knowledge, this is the first report of xanthomatosis in the family Pelecanidae.
Assuntos
Doenças das Aves/cirurgia , Aves , Xantomatose/veterinária , Animais , Doenças das Aves/patologia , Masculino , Xantomatose/patologia , Xantomatose/cirurgiaRESUMO
A loggerhead sea turtle (Caretta caretta) was found stranded alive along the Adriatic coast close to Ancona, Italy, displaying obtundation, tachypnea, and increased respiratory effort. It died a few hours after admission, and a postmortem examination was immediately performed. Miliary yellowish nodules were evident in the liver, and a lower number in the heart, stomach, and gut wall. Hundreds of whitish nodules were scattered in the lungs, with the majority of the pulmonary parenchyma being replaced by the lesions. Histologically, all nodular lesions consisted of a small central area of necrosis with acid-fast bacilli surrounded by epithelioid cells, macrophages, and lymphocytes. Giant cells were found in the spleen and the liver. Kidneys, lungs, liver, spleen, brain, and skin lesions were inoculated aseptically onto general isolation media and selective isolation media for mycobacteria. The isolate showed a restriction pattern identical to Mycobacterium chelonae by polymerase chain reaction-restriction fragment length polymorphism. To the best of the authors' knowledge, this is the first description of a disseminated infection caused by a potentially pathogenic mycobacteria in a stranded, free-ranging loggerhead sea turtle. Veterinary staff and biologists who handle sea turtles with suspected mycobacterial disease should protect themselves appropriately.
Assuntos
Infecções por Mycobacterium/veterinária , Mycobacterium chelonae/isolamento & purificação , Tartarugas , Animais , Evolução Fatal , Infecções por Mycobacterium/microbiologia , Infecções por Mycobacterium/patologiaRESUMO
Two boa constrictors (Boa constrictor imperator) presented with paresis of the trunk originating cranial to the cloaca. Radiographs were consistent with proliferative bone lesions involving several vertebrae. Computed tomography (CT) demonstrated the presence of lytic/expansile lesions. Computed tomography-guided biopsies of the lesions were performed without complications. Histology was consistent with bacterial osteomyelitis and osteoarthritis. Gram-negative bacteria (Salmonella sp. and Pseudomonas sp.) were isolated from cultures of the biopsies. Medical treatment with specific antibiotics was attempted for several weeks in both cases without clinical or radiographic improvements. The animals were euthanized, and necropsy confirmed the findings observed upon CT. To the authors' knowledge, this is the first report of the use of CT-guided biopsies to evaluate proliferative vertebral lesions in snakes. In the present report, CT-guided biopsies were easily performed, and both histologic and microbiologic results were consistent with the final diagnosis.
Assuntos
Boidae , Osteomielite/veterinária , Coluna Vertebral/patologia , Tomografia Computadorizada por Raios X/veterinária , Animais , Antibacterianos/uso terapêutico , Biópsia/métodos , Biópsia/veterinária , Feminino , Masculino , Osteomielite/diagnóstico , Osteomielite/tratamento farmacológico , Osteomielite/microbiologia , Osteomielite/patologia , Infecções por Pseudomonas/tratamento farmacológico , Infecções por Pseudomonas/microbiologia , Infecções por Pseudomonas/patologia , Infecções por Pseudomonas/veterinária , Pseudomonas aeruginosa/isolamento & purificação , Salmonelose Animal/tratamento farmacológico , Salmonelose Animal/microbiologia , Salmonelose Animal/patologia , Coluna Vertebral/microbiologiaRESUMO
BACKGROUND: Currently, a standardised technique to obtain pulse rate in reptiles is lacking. We evaluated the feasibility of obtaining a temporoorbital pulse rate in ball pythons of various ages and sizes and whether it agreed with the heart rate. METHODS: Heart rate and pulse rate were recorded in 40 ball pythons (Python regius) weighing between 0.05 and 2.2 kg using a standard veterinary ultrasonic Doppler flow detector. The temporoorbital pulse rate was obtained on the dorsal aspect of the head at the level of the temporoorbital artery. Each measurement was performed in a randomised fashion by two operators, who were blinded to each other's results. RESULTS: Pulse rate and heart rate were successfully obtained for all snakes. The median heart rate was 60 beats per minute (bpm) (range 48â88 bpm), and the median pulse rate was 60 bpm (range 48â88 bpm). The mean difference between the pulse rate and heart rate was 1.2 beats (95% limits of agreement: â10.6 to 13.0). When pulse rate and heart rate were measured at the same time, they were synchronous. LIMITATIONS: Only healthy snakes were included. CONCLUSIONS: Temporoorbital pulse rates can be easily obtained in ball pythons of any size. This novel method to assess peripheral pulse allows for a more complete cardiovascular evaluation in this species.
RESUMO
OBJECTIVE: To evaluate the topical antiseptic activity of saline, chlorhexidine (CHX), and povidone-iodine (PI) scrubs on the skin of chickens with or without the addition of DuraPrep (DP). ANIMALS: 7 healthy adult Orpington hens (Gallus gallus domesticus). METHODS: The right apterium corporale laterale was swabbed for standard aerobic bacterial culture and colony-forming unit (CFU) determination. The apterium was divided into 3 areas and treated with sterile saline, CHX, or PI. Samples were collected by swabbing each area before and after additional treatment with DP. CFU's were counted after 48 hours of incubation. Statistical analysis was performed using a linear mixed model with a continuous outcome. RESULTS: Compared to saline, CHX and PI treatment without DP decreased CFU count by 119 (95% CI, 55 to 183; P < .001) and 123 (95% CI, 58 to 187; P < .001), respectively. The application of DP after CHX and PI further decreased CFU counts by 6 (P = .01) and 9 (P = .01), respectively. DP after saline treatment decreased counts by 128 CFU (95% CI, 63 to 192; P < .001). No significant difference was detected between saline, PI, or CHX after DP application (-1.0 CFU; 95% CI, 63.4 to -65.4; P = .98 for both PI and CHX). CLINICAL RELEVANCE: CHX or PI provided greater reductions in bacterial CFU than saline, and all combinations with DP provided similar results. No notable cutaneous reactions were detected at any point. This data suggests that a scrub protocol including CHX or PI with DP is acceptable in surgical site preparation of chickens.
Assuntos
Anti-Infecciosos Locais , Galinhas , Clorexidina , Povidona-Iodo , Animais , Clorexidina/farmacologia , Clorexidina/administração & dosagem , Galinhas/microbiologia , Povidona-Iodo/farmacologia , Povidona-Iodo/administração & dosagem , Anti-Infecciosos Locais/farmacologia , Anti-Infecciosos Locais/administração & dosagem , Feminino , Solução Salina/farmacologia , Solução Salina/administração & dosagem , Pele/microbiologia , Pele/efeitos dos fármacos , Iodo/farmacologia , Iodo/administração & dosagemRESUMO
A systematic review and meta-analysis of survey research was conducted to estimate honorary authorship prevalence in health sciences. We searched PubMed, Lens.org, and Dimensions.ai. until January 5 2023. Methodological quality was assessed and quantitative syntheses were conducted. Nineteen surveys were included and rated as having low methodological quality. We found a pooled prevalence of 26% [95% CI 21-31] (6 surveys, 2758 respondents) of researchers that perceived co-author(s) as honorary on the publication at issue (when they were not referred to any authorship criteria). That prevalence was 18% [95% CI 15-21] (11 surveys, 4272 respondents) when researchers were referred to Committee of Medical Journal Editors (ICMJE) authorship criteria, and 51% [95% CI 47-56] (15 surveys, 5111 respondents) when researchers were asked to declare their co-author(s) contributions on the publication at issue (and these were then compared to ICMJE criteria). 10% of researchers [95% CI 9-12] (11 surveys, 3,663 respondents) reported being approached by others to include honorary author(s) on the publication at issue and 16% [95% CI 13-18] (2 surveys, 823 respondents) admitted adding (an) honorary author(s). Survey research consistently indicates that honorary authorship in the health sciences is highly prevalent, however the quality of the surveys' methods and reporting needs improvement.
Assuntos
Autoria , Humanos , Inquéritos e Questionários , Pesquisadores , Editoração/estatística & dados numéricosRESUMO
A systematic review with meta-analysis was conducted to assess the prevalence of automatically listing (a) senior member(s) of a department as co-author(s) on all submitted articles in health sciences and the prevalence of degrees of support on a 5-point justification scale. Survey research was searched in PubMed, Lens.org, and Dimensions.ai. until January 5 2023. We assessed the methodological quality of studies and conducted quantitative syntheses. We identified 15 eligible surveys, that provided 67 results, all of which were rated as having low quality. A pooled estimate of 20% [95% CI 16-25] (10 surveys, 3619 respondents) of researchers in various health sciences reported that a senior member of their department was automatically listed as an author on all submitted articles. Furthermore, 28% [95% CI 22-34] of researchers (10 surveys, 2180 respondents) felt that this practice was 'never', 24% [95% CI 22-27] 'rarely', 25% [95% CI 23-28] 'sometimes', 13% [95% CI 9-17] 'most of the time', and 8% [95% CI 6-9] 'always justified'. The practice of automatically assigning senior members of departments as co-authors on all submitted manuscripts may be common in the health sciences; with those admitting to this practice finding it unjustified in most cases.Registration of the protocol The protocol was registered in Open Science Framework. Link: https://osf.io/4eywp/ .