Detalhe da pesquisa
1.
A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation.
Br J Clin Pharmacol
; 90(4): 1027-1035, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37990600
2.
Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction.
Europace
; 23(11): 1847-1859, 2021 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34080619
3.
Antiarrhythmic effect of the Ca2+-activated K+ (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation.
Pflugers Arch
; 468(11-12): 1853-1863, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27722784
4.
Cardiac ion channels and mechanisms for protection against atrial fibrillation.
Rev Physiol Biochem Pharmacol
; 162: 1-58, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-21987061
5.
Attenuated ventricular ß-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure.
J Cardiovasc Pharmacol
; 59(2): 142-50, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21992969
6.
The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca(2+)-activated K(+) channels.
J Cardiovasc Pharmacol
; 57(6): 672-81, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21394037
7.
Small conductance calcium activated K+ channel inhibitor decreases stretch induced vulnerability to atrial fibrillation.
Int J Cardiol Heart Vasc
; 37: 100898, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34746364
8.
Inhibition of Small-Conductance Calcium-Activated Potassium Current (I K,Ca) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation.
Front Physiol
; 12: 614483, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33633584
9.
Inhibition of KCa2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia.
Front Pharmacol
; 11: 749, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32508659
10.
Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction.
Front Pharmacol
; 11: 556, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32435191
11.
The KCa2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs.
Front Pharmacol
; 11: 159, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32180722
12.
Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing.
Front Vet Sci
; 7: 179, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32328502
13.
Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man.
Front Pharmacol
; 11: 610, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32477117
14.
Pharmacologically induced long QT type 2 can be rescued by activation of IKs with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes.
J Cardiovasc Pharmacol
; 54(2): 169-77, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19568177
15.
The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts.
Front Pharmacol
; 10: 668, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31275147
16.
Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs.
Circ Arrhythm Electrophysiol
; 10(10)2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29018164
17.
Synergistic antiarrhythmic effect of combining inhibition of Ca²âº-activated K⺠(SK) channels and voltage-gated Na⺠channels in an isolated heart model of atrial fibrillation.
Heart Rhythm
; 12(2): 409-18, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25496982
18.
Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses.
Heart Rhythm
; 12(4): 825-35, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25542425
19.
Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria.
Cardiovasc Res
; 103(1): 156-67, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24817686
20.
Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation.
Circ Arrhythm Electrophysiol
; 3(4): 380-90, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20562443