Detalhe da pesquisa
1.
Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature
; 550(7677): 481-486, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29045389
2.
Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor.
J Pharmacol Exp Ther
; 361(2): 229-244, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193636
3.
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.
Bioorg Med Chem Lett
; 27(4): 1062-1069, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28131713
4.
Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors.
Bioorg Med Chem Lett
; 26(7): 1803-8, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26927423
5.
The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization.
Bioorg Med Chem Lett
; 24(6): 1466-71, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24582987
6.
The deubiquitylase USP9X controls ribosomal stalling.
J Cell Biol
; 220(3)2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33507233
7.
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
Elife
; 102021 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34636321
8.
The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: hit to lead.
Bioorg Med Chem Lett
; 20(24): 7421-5, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21044843
9.
Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel.
Bioorg Med Chem Lett
; 20(8): 2493-6, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20304642
10.
Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor.
J Med Chem
; 63(4): 1612-1623, 2020 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31971798
11.
Preparation of a stable trifluoroborate salt for the synthesis of 1-aryl-2,2-difluoro-enolethers and/or 2,2-difluoro-1-aryl-ketones via palladium-mediated cross-coupling.
J Org Chem
; 74(22): 8866-9, 2009 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19845317
12.
Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.
J Med Chem
; 62(14): 6575-6596, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31199148
13.
Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure.
J Pharmacol Exp Ther
; 324(1): 322-30, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17967939
14.
The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.
J Med Chem
; 60(23): 9676-9690, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29156136
15.
Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation.
J Med Chem
; 49(24): 6954-7, 2006 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125248
16.
Correction: The deubiquitylase USP9X controls ribosomal stalling.
J Cell Biol
; 220(3)2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33600552
17.
Inhibitors of farnesyltransferase and geranylgeranyltransferase-I for antitumor therapy: substrate-based design, conformational constraint and biological activity.
Curr Top Med Chem
; 3(10): 1075-93, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12769709
18.
Carboxylation and Mitsunobu reaction of amines to give carbamates: retention vs inversion of configuration is substituent-dependent.
Org Lett
; 6(17): 2885-8, 2004 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15330639
19.
Preparation of substituted piperazinones via tandem reductive amination-(N,N'-acyl transfer)-cyclization.
Org Lett
; 4(7): 1201-4, 2002 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-11922818
20.
Nonconventional Stereochemical Issues in the Design of the Synthesis of the Vancomycin Antibiotics: Challenges Imposed by Axial and Nonplanar Chiral Elements in the Heptapeptide Aglycons.
Angew Chem Int Ed Engl
; 37(19): 2704-2708, 1998 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29711602