1.
Clin Lung Cancer
; 25(5): 479-482, 2024 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38777674
Assuntos
Adenocarcinoma de Pulmão , Receptores ErbB , Mutação em Linhagem Germinativa , Neoplasias Pulmonares , Humanos , Receptores ErbB/genética , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patologia , Adenocarcinoma de Pulmão/genética , Adenocarcinoma de Pulmão/patologia , Masculino , Feminino , Pessoa de Meia-Idade
2.
Semin Oncol
; 39(2): 163-72, 2012 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22484188
RESUMO
Merkel cell carcinoma (MCC) is a highly aggressive skin malignancy. The growing incidence and recognition of this cancer in elderly or immunosuppressed individuals suggests that it is becoming an increasing clinical challenge. MCC recently has been demonstrated to have a probable viral pathogenesis related to a novel member of the polyomavirus (termed Merkel cell polyomavirus [MCV]). The molecular pathogenesis of viral carcinogenesis is currently being worked out in MCC. Current diagnostic and therapeutic strategies are discussed, with an eye toward the future development of molecularly targeted treatments.