Detalhe da pesquisa
1.
A mouse model of a human congenital disorder of glycosylation caused by loss of PMM2.
Hum Mol Genet
; 25(11): 2182-2193, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27053713
2.
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.
Proc Natl Acad Sci U S A
; 112(29): 9088-93, 2015 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26150517
3.
IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition.
Blood
; 125(2): 296-303, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25398940
4.
PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene.
Blood
; 124(11): 1777-89, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25006129
5.
A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model.
J Inherit Metab Dis
; 39(6): 807-820, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27469509
6.
Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.
J Biol Chem
; 288(42): 30125-30138, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24003220
7.
An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva.
Sci Transl Med
; 16(749): eabp8334, 2024 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38809966
8.
Validating cancer drug targets.
Nature
; 441(7092): 451-6, 2006 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-16724057
9.
Distinct effects of the soluble versus membrane-bound forms of the notch ligand delta-4 on human CD34+CD38low cell expansion and differentiation.
Stem Cells
; 26(3): 621-9, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18055448
10.
Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma.
Cancer Discov
; 9(12): 1686-1695, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31575540
11.
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
Nat Commun
; 10(1): 96, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30626880
12.
Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2.
Cell Signal
; 18(12): 2223-9, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16824733
13.
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
Cancer Discov
; 7(5): 478-493, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193778
14.
Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases.
Autoimmunity
; 39(6): 469-78, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17060026
15.
PK1/EG-VEGF induces monocyte differentiation and activation.
J Leukoc Biol
; 78(2): 426-34, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15908459
16.
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.
Cell Rep
; 15(3): 574-587, 2016 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27068473
17.
Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH.
Cell Rep
; 17(3): 876-890, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27732861
18.
Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.
PLoS One
; 9(12): e115144, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25502225
19.
Unraveling the therapeutic potential of the Hedgehog pathway in cancer.
Nat Med
; 19(11): 1410-22, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24202394
20.
Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.
Nat Med
; 19(11): 1518-23, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24076665