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1.
Curr Oncol ; 21(5): e704-14, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25302041

RESUMO

BACKGROUND: The treatment of head-and-neck cancer is complex and requires the involvement of various health care professionals with a wide range of expertise. We describe the process of developing a practice guideline with recommendations about the organization and delivery of health care services for head-and-neck cancer patients in Alberta. METHODS: Outcomes of interest included composition of the health care team, qualification requirements for team members, cancer centre and team member volumes, infrastructure needs, and wait times. A search for existing practice guidelines and a systematic review of the literature addressing the organization and delivery of health care services for head-and-neck cancer patients were conducted. The search included the Standards and Guidelines Evidence (sage) directory of cancer guidelines and PubMed. RESULTS: One practice guideline was identified for adaptation. Three additional practice guidelines provided supplementary evidence to inform guideline recommendations. Members of the Alberta Provincial Head and Neck Tumour Team (consisting of various health professionals from across the province) provided expert feedback on the adapted recommendations through an online and in-person review process. Selected experts in head-and-neck cancer from outside the province participated in an external online review. SUMMARY: The recommendations outlined in this practice guideline are based on existing guidelines that have been modified to fit the Alberta context. Although specific to Alberta, the recommendations lend credence to similar published guidelines and could be considered for use by groups lacking the resources of appointed guideline panels. The recommendations are meant to be a guide rather than a fixed protocol. The implementation of this practice guideline will depend on many factors, including but not limited to availability of trained personnel, adequate funding of infrastructure, and collaboration with other associations of health care professionals in the province.

2.
Br J Cancer ; 109(7): 1859-66, 2013 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-24008660

RESUMO

BACKGROUND: Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell carcinoma (OSCC). In addition to hypoxia, CAIX expression is regulated by proliferation-associated signalling. We hypothesised that incorporating Ki67, a proliferation marker, into our existing CAIX-based stratification of OSCC would identify patients with the least favourable prognosis. METHODS: Surgically resected tumours from 60 OSCC patients were analysed for CAIX, Ki67 and BAX expression using fluorescence immunohistochemistry and automated quantitative analysis (AQUA). RESULTS: In patients expressing high stromal CAIX (sCAIX), stratification by tumour Ki67 expression revealed significantly distinct survival outcomes (P=0.005). In our OSCC cohort, below-median Ki67 and top-quartile sCAIX expression (Ki67(lo)sCAIX(hi)) were associated with significantly worse disease-specific survival in univariate (HR 7.2 (2.5-20.4), P=0.001) and multivariate (HR 4.2 (1.4-12.8), P=0.011) analyses. Hypoxia is associated with decreased BAX expression; the Ki67(lo)sCAIX(hi) group was more strongly associated with low BAX expression than high sCAIX alone. CONCLUSION: These data suggest that combined analysis of tumour Ki67 and sCAIX expression may provide a more clinically relevant assessment of tumour hypoxia in OSCC.


Assuntos
Antígenos de Neoplasias/metabolismo , Anidrases Carbônicas/metabolismo , Carcinoma de Células Escamosas/metabolismo , Antígeno Ki-67/metabolismo , Neoplasias Bucais/metabolismo , Proteína X Associada a bcl-2/metabolismo , Apoptose , Biomarcadores Tumorais/metabolismo , Anidrase Carbônica IX , Carcinoma de Células Escamosas/mortalidade , Hipóxia Celular , Resistencia a Medicamentos Antineoplásicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/mortalidade , Prognóstico , Sobrevida , Resultado do Tratamento
3.
J Clin Virol ; 75: 37-41, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26780110

RESUMO

BACKGROUND: Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is a growing problem that presents a significant challenge to Otolaryngologist-Head and Neck Surgeons. Knowledge of HPV status yields critical prognostic information, with potential for treatment selection based on tumour HPV status. The current gold standard of diagnosis, PCR, is expensive, demanding and time consuming. Alternatives such as p16 immunohistochemistry are subjective and potentially inaccurate. Loop-mediated isothermal amplification (LAMP) is a rapid, robust and inexpensive molecular diagnostic technique. OBJECTIVES: Our aim was to verify LAMP as a potential bedside diagnostic assay for subtyping of HPV in OPSCC. STUDY DESIGN: DNA from 72 formalin-fixed paraffin embedded (FFPE) OPSCC patient samples was tested. PCR and LAMP were then performed to specifically identify HPV 16, 18, 31, 33 and 35. RESULTS AND CONCLUSIONS: For these high-risk subtypes, LAMP had an overall sensitivity of 99.4% and specificity of 93.2% relative to PCR. LAMP is a promising technology that can accurately diagnose high-risk HPV infection.


Assuntos
Carcinoma de Células Escamosas , Testes de DNA para Papilomavírus Humano/métodos , Técnicas de Amplificação de Ácido Nucleico , Neoplasias Orofaríngeas , Papillomaviridae/isolamento & purificação , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/virologia , Papillomavirus Humano 16/isolamento & purificação , Papillomavirus Humano 18/isolamento & purificação , Papillomavirus Humano 31/isolamento & purificação , Humanos , Neoplasias Orofaríngeas/diagnóstico , Neoplasias Orofaríngeas/virologia , Papillomaviridae/classificação , Sensibilidade e Especificidade
4.
AJNR Am J Neuroradiol ; 36(1): 166-70, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25258367

RESUMO

BACKGROUND AND PURPOSE: Head and neck cancer is common, and understanding the prognosis is an important part of patient management. In addition to the Tumor, Node, Metastasis staging system, tumor biomarkers are becoming more useful in understanding prognosis and directing treatment. We assessed whether MR imaging texture analysis would correctly classify oropharyngeal squamous cell carcinoma according to p53 status. MATERIALS AND METHODS: A cohort of 16 patients with oropharyngeal squamous cell carcinoma was prospectively evaluated by using standard clinical, histopathologic, and imaging techniques. Tumors were stained for p53 and scored by an anatomic pathologist. Regions of interest on MR imaging were selected by a neuroradiologist and then analyzed by using our 2D fast time-frequency transform tool. The quantified textures were assessed by using the subset-size forward-selection algorithm in the Waikato Environment for Knowledge Analysis. Features found to be significant were used to create a statistical model to predict p53 status. The model was tested by using a Bayesian network classifier with 10-fold stratified cross-validation. RESULTS: Feature selection identified 7 significant texture variables that were used in a predictive model. The resulting model predicted p53 status with 81.3% accuracy (P < .05). Cross-validation showed a moderate level of agreement (κ = 0.625). CONCLUSIONS: This study shows that MR imaging texture analysis correctly predicts p53 status in oropharyngeal squamous cell carcinoma with ∼80% accuracy. As our knowledge of and dependence on tumor biomarkers expand, MR imaging texture analysis warrants further study in oropharyngeal squamous cell carcinoma and other head and neck tumors.


Assuntos
Carcinoma de Células Escamosas/patologia , Neoplasias de Cabeça e Pescoço/patologia , Interpretação de Imagem Assistida por Computador/métodos , Neoplasias Orofaríngeas/patologia , Proteína Supressora de Tumor p53/biossíntese , Adulto , Teorema de Bayes , Biomarcadores Tumorais/análise , Carcinoma de Células Escamosas/classificação , Feminino , Neoplasias de Cabeça e Pescoço/classificação , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias Orofaríngeas/classificação , Carcinoma de Células Escamosas de Cabeça e Pescoço
5.
J Appl Physiol (1985) ; 87(1): 444-51, 1999 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10409606

RESUMO

Development of drug treatments for obstructive sleep-disordered breathing has been impeded by the lack of animal models. The obese pig may be a suitable animal model, as it has been reported to experience sleep-disordered breathing resembling human obstructive sleep apnea. The purpose of this paper is to describe in detail techniques for chronic instrumentation of the obese Vietnamese pot-bellied pig and to study respiratory function during sleep. Under general anesthesia, four obese pigs were instrumented for long-term recording of intrapleural and tracheal pressures, genioglossal EMG, and bioelectric signals related to sleep. A custom-fitted face mask was used to record respiratory variables including airflow, snoring, and expired CO(2). Most chronic instrumentation provided robust signals for up to 6 wk after installation. All pigs displayed sleep-disordered breathing characterized by increased resistance to airflow, snoring, inspiratory flow limitation, and possible sleep disruption. Apneas and hypopneas were not a feature of breathing during sleep in these animals. Nonetheless, this animal preparation may be useful for exploring possible drug treatments for obstructive sleep-disordered breathing.


Assuntos
Monitorização Fisiológica/veterinária , Testes de Função Respiratória/veterinária , Síndromes da Apneia do Sono/veterinária , Sono/fisiologia , Doenças dos Suínos/fisiopatologia , Animais , Modelos Animais de Doenças , Eletromiografia/instrumentação , Eletromiografia/veterinária , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Monitorização Fisiológica/instrumentação , Troca Gasosa Pulmonar/fisiologia , Testes de Função Respiratória/instrumentação , Mecânica Respiratória/fisiologia , Músculos Respiratórios/fisiopatologia , Síndromes da Apneia do Sono/fisiopatologia , Fases do Sono/fisiologia , Suínos
6.
Laryngoscope ; 100(10 Pt 1): 1100-5, 1990 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-2215043

RESUMO

The purpose of this study is to define the indications for using the CO2 laser for the treatment of early glottic cancer. For this purpose, 52 consecutive laser resections of Tis to T2 vocal cord carcinomas were studied prospectively. In addition, laser resection was performed in eight human cadaver larynges, which were then examined histologically using whole organ sections. Both tumor size and tumor location had important influences on tumor resectability by laser. All of the Tis, 78% of T1, and one of four T2 carcinomas were successfully treated by laser surgery alone. Of the 10 carcinomas involving the anterior commissure, only four could completely be resected with the laser; of these four, two recurred in the anterior commissure. This finding is corroborated by the histologic study, which clearly shows that anterior commissure resection poses problems. The only laser resection complication of early glottic cancer was persistent hoarseness in one third of the patients. It is concluded that CO2 laser resection is a safe and effective alternative treatment for patients with Tis and T1 glottic carcinoma, provided the anterior commissure is free of tumor.


Assuntos
Carcinoma de Células Escamosas/cirurgia , Neoplasias Laríngeas/cirurgia , Laringoscopia/métodos , Terapia a Laser/métodos , Prega Vocal/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma in Situ/cirurgia , Carcinoma de Células Escamosas/patologia , Terapia Combinada , Feminino , Humanos , Neoplasias Laríngeas/patologia , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/cirurgia , Estadiamento de Neoplasias , Estudos Prospectivos
7.
Laryngoscope ; 111(9): 1570-5, 2001 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11568606

RESUMO

OBJECTIVES/HYPOTHESIS: Skull base surgery has evolved over the past several decades. Major improvements in the imaging of skull base pathology led to better target localization and better surgical planning. The objectives of this study were to assess the use of intraoperative magnetic resonance (MR) imaging in the management of a series of patients with skull base pathology. We hypothesized that high-quality intraoperative MR imaging would have an impact on surgery in this patient group. STUDY DESIGN: Prospective, non-randomized, cohort study. METHODS: Thirty-one patients with skull base lesions underwent surgery in a 1.5-Tesla intraoperative MR suite. The concepts of a moving magnet, high magnetic field strength, and radiofrequency coil design are presented. RESULTS: Eleven of 31 patients had the course of surgery significantly altered by the information acquired from the images obtained during surgery. CONCLUSIONS: Intraoperative MR imaging is a valuable adjunct to skull base surgery. One third of patients had altered surgery as a result of this adjunct. Intraoperative MR imaging is of particular value in the treatment of pituitary adenomas and benign skull base tumors.


Assuntos
Adenoma/patologia , Adenoma/cirurgia , Cuidados Intraoperatórios/métodos , Imageamento por Ressonância Magnética/métodos , Meningioma/patologia , Meningioma/cirurgia , Neurilemoma/patologia , Neurilemoma/cirurgia , Neoplasias Hipofisárias/patologia , Neoplasias Hipofisárias/cirurgia , Neoplasias da Base do Crânio/patologia , Neoplasias da Base do Crânio/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Dissecação , Feminino , Humanos , Cuidados Intraoperatórios/instrumentação , Cuidados Intraoperatórios/normas , Imageamento por Ressonância Magnética/instrumentação , Imageamento por Ressonância Magnética/normas , Masculino , Pessoa de Meia-Idade , Seleção de Pacientes , Estudos Prospectivos , Garantia da Qualidade dos Cuidados de Saúde
8.
Can J Neurol Sci ; 28(1): 47-50, 2001 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-11252294

RESUMO

BACKGROUND: Unilateral audiovestibular symptoms are commonly seen in clinical practice and are rarely caused by retrocochlear pathology. However, clinicians are often required to rule out potentially serious causes of these unilateral symptoms. Gadolinium enhanced magnetic resonance imaging (GdMRI) is the most accurate test for detecting small cerebellopontine angle lesions and also screens the adjacent CNS structures. Its main disadvantage is the cost of the procedure. METHODS: We studied 100 consecutive patients with both GdMRI and a newer MRI screening study utilizing unenhanced T2-weighted fast spin echo (fse) MRI. Acquired images were randomly assessed by a panel of three neuro-radiologists. RESULTS: We found that the screening (fse) MRI was as sensitive and specific when detecting cerebellopontine angle tumors. CONCLUSIONS: We conclude that T2-weighted fse MRI is a safe and cost-effective alternative to GdMRI and offers better diagnostic utility when compared to auditory brain stem response (ABR) and CT scans.


Assuntos
Neoplasias Cerebelares/diagnóstico , Neoplasias Cerebelares/patologia , Ângulo Cerebelopontino/patologia , Imageamento por Ressonância Magnética/métodos , Tronco Encefálico/patologia , Neoplasias Cerebelares/economia , Gadolínio , Humanos , Imageamento por Ressonância Magnética/economia , Estudos Prospectivos
9.
Otolaryngol Head Neck Surg ; 114(2): 308-9, 1996 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-8637758

RESUMO

A patient with posttraumatic macroglossia has been presented. A literature review reveals that this is a rare sequela of tongue injury and is usually of acute onset. The delayed symptom of swelling in this patient and the exacerbation of swelling in association with hyaluronidase suggest a causal relationship between the two events. Macroglossia has not been reported in association with hyaluronidase injection, and it is recommended that the drug not be used to treat swelling after tongue injury.


Assuntos
Hialuronoglucosaminidase/efeitos adversos , Macroglossia/etiologia , Língua/lesões , Adulto , Mordeduras Humanas , Edema/tratamento farmacológico , Humanos , Hialuronoglucosaminidase/administração & dosagem , Injeções , Macroglossia/induzido quimicamente , Masculino , Esqui/lesões , Doenças da Língua/tratamento farmacológico
10.
Otolaryngol Head Neck Surg ; 125(6): 617-22, 2001 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11743463

RESUMO

OBJECTIVE: To determine changes in skeletal muscle metabolism after nerve transection and repair and to correlate metabolic changes with functional recovery. STUDY DESIGN AND SETTING: Male Wistar rats were divided into 6 experimental groups plus a control group. The posterior tibial nerve was transected and reapproximated. At varying times after surgery (1, 2, 4, 6, or 8 weeks) animals were sacrificed, the gastrocnemius muscle was harvested, and proton nuclear magnetic resonance (NMR) spectroscopy was performed. Functional recovery was measured using the sciatic function index. RESULTS: Animals undergoing nerve repair all showed functional recovery whereas the nonrepaired nerve group did not. Concentration of glucose and lactate increased after denervation and then returned toward normal. Choline concentration decreased and then returned toward normal. In animals not undergoing nerve repair, the metabolic abnormalities persisted and showed no sign of recovery over the 8-week observation period. CONCLUSIONS: 1H NMR spectroscopy is a potentially useful tool to study changes in skeletal muscle metabolism after motor nerve injury. SIGNIFICANCE: NMR spectroscopy is rapidly developing into a clinically useful tool. High-field magnets have improved resolution and data acquisition. Basic experiments, such as those described here, will help guide the use of NMR spectroscopy in clinical medicine and will also lead to a better understanding of basic mechanisms of nerve injury and repair.


Assuntos
Modelos Animais de Doenças , Espectroscopia de Ressonância Magnética/métodos , Denervação Muscular , Músculo Esquelético/inervação , Músculo Esquelético/metabolismo , Reimplante , Nervo Tibial/cirurgia , Potenciais de Ação , Análise de Variância , Animais , Colina/análise , Eletromiografia , Glucose/análise , Ácido Láctico/análise , Espectroscopia de Ressonância Magnética/instrumentação , Espectroscopia de Ressonância Magnética/normas , Masculino , Denervação Muscular/efeitos adversos , Denervação Muscular/métodos , Músculo Esquelético/química , Músculo Esquelético/fisiologia , Ratos , Ratos Wistar , Tempo de Reação , Recuperação de Função Fisiológica , Reimplante/instrumentação , Reimplante/métodos , Nervo Isquiático/fisiologia , Fatores de Tempo
11.
Acta Cytol ; 41(4): 1023-30, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-9250294

RESUMO

OBJECTIVE: To study the fine needle aspiration cytology of lymphoepithelial carcinoma of salivary gland (LECSG). STUDY DESIGN: Needle aspirates from five primary and two metastatic LECSGs were reviewed. RESULTS: Three aspirates showed very scant cellularity with rare tumor cells originally misinterpreted as lymphohistiocytic cells. Six fine needle aspiration biopsies (FNABs) contained medium to large polygonal and spindled cells with one or more prominent nucleoli. Five aspirates also displayed a heterogeneous population of lymphoid cells, while a sixth had much necrotic debris and only a few lymphocytes admixed with tumor cells. CONCLUSION: In the clinical setting of an Inuit or Chinese patient with a salivary gland mass, an FNAB with these features should suggest the possibility of LECSG.


Assuntos
Carcinoma de Células Escamosas/patologia , Neoplasias das Glândulas Salivares/patologia , Adulto , Biópsia por Agulha , Feminino , Seguimentos , Humanos , Metástase Linfática/patologia , Masculino , Pessoa de Meia-Idade
12.
J Laryngol Otol ; 105(8): 687-92, 1991 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-1919333

RESUMO

Primary extramedullary plasmacytomas (PEMP) are uncommon plasma cell neoplasms that generally occur in the submucosal tissue of the upper airway. Salivary gland PEMP is an extremely rare condition. This report describes a unique case of PEMP in the parotid gland associated with pulmonary amyloidosis. A review of all salivary gland PEMP's suggests that they behave similarly to PEMP's in other locations. The treatment of choice for localized disease is radiotherapy which should include regional lymphatics. Local control can be achieved in the majority of cases. The minority of patients develop systemic metastases and die from their disease. Chemotherapy can control disseminated disease and may induce remission.


Assuntos
Plasmocitoma/patologia , Neoplasias das Glândulas Salivares/patologia , Idoso , Amiloidose/complicações , Feminino , Humanos , Imunoglobulina G/análise , Neoplasias Parotídeas/química , Neoplasias Parotídeas/complicações , Neoplasias Parotídeas/patologia , Plasmocitoma/química , Plasmocitoma/complicações
13.
J Laryngol Otol ; 108(6): 466-9, 1994 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-8027642

RESUMO

The facial nerve is often injured by trauma, infection or during the course of tumour resection. Many techniques of nerve anastomosis have been described with the current standard nerve repair using the microscope and monofilament suture. The purpose of this study was to evaluate the CO2 surgical laser as a tool for facial nerve anastomosis. Following preliminary electrical measurements 36 nerves were anastomosed using either laser or conventional monofilament suture. Laser anastomosis had neither beneficial nor detrimental effects on nerve regeneration. This method of anastomosis may be advantageous when surgical access is limited. In addition this study found that the use of CO2 laser as a dissecting or vapourizing tool in proximity to intact facial nerves results in degenerative changes.


Assuntos
Nervo Facial/cirurgia , Terapia a Laser/métodos , Anastomose Cirúrgica , Animais , Dióxido de Carbono , Eletrofisiologia , Nervo Facial/patologia , Nervo Facial/fisiopatologia , Traumatismos do Nervo Facial , Masculino , Ratos , Ratos Endogâmicos
14.
J Laryngol Otol ; 104(4): 301-4, 1990 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-2370450

RESUMO

The manifestations of Lyme disease as they may present to the ENT surgeon are discussed. The most important ENT symptom is facial palsy. Particularly when combined with other cranial palsies, systemic illness or signs of meningeal irritation, the diagnosis must be considered. Three case reports are used to illustrate the presentation and diagnosis and treatment of Lyme disease. The characteristics of the disease are reviewed and the limitations of serological testing outlined. The literature has concentrated on bilateral or relapsing facial palsy. A review of palsies in Zurich that presented to the ENT clinic found only unilateral and partial palsies. The diagnosis should be considered in every case of facial palsy of unknown aetiology especially in children.


Assuntos
Eritema Migrans Crônico/etiologia , Dermatoses Faciais/etiologia , Paralisia Facial/etiologia , Doença de Lyme/complicações , Adulto , Pré-Escolar , Feminino , Cefaleia/etiologia , Perda Auditiva Neurossensorial/etiologia , Humanos , Doença de Lyme/diagnóstico , Meningismo/etiologia , Pessoa de Meia-Idade , Zumbido/etiologia
15.
J Laryngol Otol ; 107(3): 252-6, 1993 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-8509708

RESUMO

Solitary fibrous tumours are uncommon spindle cell neoplasms generally associated with serosal surfaces, especially the pleura ('localized fibrous mesothelioma'). Recently, these tumours have been documented in extraserosal sites. We report two solitary fibrous tumours, including one occurring in the paediatric age group, arising in two previously unreported locations, parapharyngeal space and epiglottis. These cases expand the range of sites where this tumour may originate and confirm the tendency of extrapleural cases to involve the upper respiratory tract and adjacent structures.


Assuntos
Neoplasias Laríngeas/patologia , Mesotelioma/patologia , Neoplasias Faríngeas/patologia , Adolescente , Humanos , Neoplasias Laríngeas/diagnóstico por imagem , Masculino , Mesotelioma/diagnóstico por imagem , Pessoa de Meia-Idade , Neoplasias Faríngeas/diagnóstico por imagem , Tomografia Computadorizada por Raios X
19.
J Otolaryngol ; 24(1): 69-72, 1995 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-7769650

RESUMO

Cases of physical trauma have become more common in emergency departments, since life in modern society has become increasingly dangerous. Foreign bodies in the head and neck region are more common, therefore, and management principles are well-defined. Typically, these foreign bodies are metal, plastic, or glass and often easily diagnosed; however, wooden foreign bodies pose special problems for the physician and, therefore, warrant separate consideration. We present the case of a 21-year-old male who was stabbed in the submental region with a large wooden stake and discuss the surgical and follow-up treatment of this interesting case, including the roles and limitations of angiography, computerized tomography, and magnetic resonance imaging.


Assuntos
Corpos Estranhos/fisiopatologia , Crânio/fisiopatologia , Adulto , Otorreia de Líquido Cefalorraquidiano/etiologia , Corpos Estranhos/complicações , Corpos Estranhos/diagnóstico , Transtornos da Audição/etiologia , Humanos , Masculino , Tomografia Computadorizada por Raios X , Trismo/etiologia
20.
J Otolaryngol ; 23(2): 121-4, 1994 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-8028069

RESUMO

Chronic otitis media is frequently seen in otolaryngologic practice. Cholesteatoma is less common and can present a diagnostic challenge. Temporal bone imaging studies are often used both to support the clinical diagnosis of cholesteatoma and to ascertain the extent of the disease. The exact role of CT in patients with cholesteatoma is unclear. This retrospective study compares CT with the operative findings in 44 patients operated on for cholesteatoma. Results show that while CT can detect abnormalities in the temporal bone, its ability to diagnose cholesteatoma is poor. We conclude that CT should be used selectively in those patients presenting diagnostic dilemmas or when other concomitant pathology (i.e., complications, recurrent disease, etc.) is suspected.


Assuntos
Colesteatoma/diagnóstico por imagem , Orelha Média/diagnóstico por imagem , Osso Temporal/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Adolescente , Adulto , Doenças Ósseas/diagnóstico por imagem , Doenças Ósseas/patologia , Doenças Ósseas/cirurgia , Colesteatoma/patologia , Colesteatoma/cirurgia , Colesterol , Técnicas de Diagnóstico por Cirurgia , Otopatias/diagnóstico por imagem , Otopatias/patologia , Otopatias/cirurgia , Orelha Média/patologia , Orelha Média/cirurgia , Exsudatos e Transudatos , Feminino , Tecido de Granulação/patologia , Granuloma de Corpo Estranho/patologia , Humanos , Hipertrofia , Masculino , Processo Mastoide/cirurgia , Pessoa de Meia-Idade , Osteotomia , Otite Média/cirurgia , Estudos Retrospectivos , Sensibilidade e Especificidade , Osso Temporal/patologia , Osso Temporal/cirurgia , Timpanoplastia
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