1.
Chemistry
; 16(31): 9606-15, 2010 Aug 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20521287
RESUMO
A straightforward two-step synthesis of trans-3,4-disubstituted succinimides through a palladium-catalyzed Sonogashira reaction and an iron-catalyzed double carbonylation is described. In situ oxidative dehydrogenation gave the corresponding 3,4-diarylmaleimides. By starting from readily available aryl and heteroaryl halides, a variety of new analogues and derivatives of bioactive 3,4-bisindolylmaleimides are obtained in good yield and selectivity.
Assuntos
Ferro/química , Maleimidas/química , Maleimidas/síntese química , Succinimidas/química , Succinimidas/síntese química , Catálise , Humanos , Estrutura Molecular
2.
Org Biomol Chem
; 6(22): 4218-23, 2008 Nov 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18972053
RESUMO
N-glycosides of 6H-indolo[2,3-b]quinoxalines were prepared and structurally characterized. The synthesis relies on the cyclocondensation of isatine-N-glycosides with 1,2-diaminobenzenes. Some products exhibit weak cytotoxic activity against human ceratinocytes (HaCaT).
Assuntos
Glicosídeos/síntese química , Glicosídeos/toxicidade , Indóis/química , Queratinócitos/efeitos dos fármacos , Quinoxalinas/química , Glicosídeos/química , Humanos
3.
4.
5.
Chem Asian J
; 5(10): 2173-6, 2010 Oct 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20658508