RESUMO
OBJECTIVE: To explorer the efficacies of continuous high volume hemofiltration (CHVHF) in severe sepsis patients with multiple organ dysfunction syndrome (MODS). METHODS: A total of 80 cases of severe sepsis patients with MODS treated at our center from 2011 January to 2013 October were selected and assigned to receive CHVHF (n = 42) and continuous volume hemofiltration (CVHF, n = 38). The changes of vital signs, acute physiology & chronic health evaluationII (APACHEII) scores, MODS evaluation scores, hemodynamics, liver & kidney function parameters, arterial blood lactate and procalcitonin (PCT) were observed before and after treatment. RESULTS: After treatment, their temperatures and heart rates improved and the scores of APACHEIIand MODS were significantly lower (P < 0.05). Hemodynamics significantly improved at 48 and 72 h post-treatment. The values of mean arterial pressure (MAP), cardiac index (CI), stroke volume index (SVI) and systemic vascular resistance index (SVRI) became stabilized as compared with pre-treatment. There were significant differences (P < 0.05). The parameters of liver and kidney function gradually improved after CHVHF. And arterial blood lactate and PCT returned to normal at 24, 48 and 72 h post-treatment (P < 0.05). CONCLUSION: CHVHF may stabilize vital signs and improve hemodynamics, organ function and tissue perfusion in septic patients with MODS.