Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders.

Frost, Bess; Dubnau, Josh.

Annu Rev Neurosci ; 2024 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-38663088

2.

TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.

Krupp, Sarah; Hubbard, Isabel; Tam, Oliver; Hammell, Gale M; Dubnau, Josh.

PLoS Genet ; 19(9): e1010973, 2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37747929

3.

A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia.

Azpurua, Jorge; El-Karim, Enas Gad; Tranquille, Marvel; Dubnau, Josh.

PLoS Genet ; 17(11): e1009882, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34723963

4.

Intercellular viral spread and intracellular transposition of Drosophila gypsy.

Keegan, Richard M; Talbot, Lillian R; Chang, Yung-Heng; Metzger, Michael J; Dubnau, Josh.

PLoS Genet ; 17(4): e1009535, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33886543

5.

Cellular labeling of endogenous retrovirus replication (CLEVR) reveals de novo insertions of the gypsy retrotransposable element in cell culture and in both neurons and glial cells of aging fruit flies.

Chang, Yung-Heng; Keegan, Richard M; Prazak, Lisa; Dubnau, Josh.

PLoS Biol ; 17(5): e3000278, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-31095565

6.

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS.

Krug, Lisa; Chatterjee, Nabanita; Borges-Monroy, Rebeca; Hearn, Stephen; Liao, Wen-Wei; Morrill, Kathleen; Prazak, Lisa; Rozhkov, Nikolay; Theodorou, Delphine; Hammell, Molly; Dubnau, Josh.

PLoS Genet ; 13(3): e1006635, 2017 03.

Artigo em Inglês | MEDLINE | ID: mdl-28301478

7.

MicroRNA-276a functions in ellipsoid body and mushroom body neurons for naive and conditioned olfactory avoidance in Drosophila.

Li, Wanhe; Cressy, Michael; Qin, Hongtao; Fulga, Tudor; Van Vactor, David; Dubnau, Josh.

J Neurosci ; 33(13): 5821-33, 2013 Mar 27.

Artigo em Inglês | MEDLINE | ID: mdl-23536094

8.

Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila.

Lee, Pei-Tseng; Lin, Hsuan-Wen; Chang, Yu-Hsuan; Fu, Tsai-Feng; Dubnau, Josh; Hirsh, Jay; Lee, Tzumin; Chiang, Ann-Shyn.

Proc Natl Acad Sci U S A ; 108(33): 13794-9, 2011 Aug 16.

Artigo em Inglês | MEDLINE | ID: mdl-21808003

9.

Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration.

Chang, Yung-Heng; Dubnau, Josh.

Nat Commun ; 14(1): 966, 2023 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-36810738

10.

Josh Dubnau.

Dubnau, Josh.

Curr Biol ; 31(2): R55-R57, 2021 01 25.

Artigo em Inglês | MEDLINE | ID: mdl-33497627

11.

Identification of synaptic targets of Drosophila pumilio.

Chen, Gengxin; Li, Wanhe; Zhang, Qing-Shuo; Regulski, Michael; Sinha, Nishi; Barditch, Jody; Tully, Tim; Krainer, Adrian R; Zhang, Michael Q; Dubnau, Josh.

PLoS Comput Biol ; 4(2): e1000026, 2008 Feb 29.

Artigo em Inglês | MEDLINE | ID: mdl-18463699

12.

The Gypsy Endogenous Retrovirus Drives Non-Cell-Autonomous Propagation in a Drosophila TDP-43 Model of Neurodegeneration.

Chang, Yung-Heng; Dubnau, Josh.

Curr Biol ; 29(19): 3135-3152.e4, 2019 10 07.

Artigo em Inglês | MEDLINE | ID: mdl-31495585

13.

Nuclear Transcriptomes of the Seven Neuronal Cell Types That Constitute the Drosophila Mushroom Bodies.

Shih, Meng-Fu Maxwell; Davis, Fred Pejman; Henry, Gilbert Lee; Dubnau, Josh.

G3 (Bethesda) ; 9(1): 81-94, 2019 01 09.

Artigo em Inglês | MEDLINE | ID: mdl-30397017

14.

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia.

Tam, Oliver H; Rozhkov, Nikolay V; Shaw, Regina; Kim, Duyang; Hubbard, Isabel; Fennessey, Samantha; Propp, Nadia; Fagegaltier, Delphine; Harris, Brent T; Ostrow, Lyle W; Phatnani, Hemali; Ravits, John; Dubnau, Josh; Gale Hammell, Molly.

Cell Rep ; 29(5): 1164-1177.e5, 2019 10 29.

Artigo em Inglês | MEDLINE | ID: mdl-31665631

15.

Deconstructing memory in Drosophila.

Margulies, Carla; Tully, Tim; Dubnau, Josh.

Curr Biol ; 15(17): R700-13, 2005 Sep 06.

Artigo em Inglês | MEDLINE | ID: mdl-16139203

16.

Ethanol sensitivity and tolerance in long-term memory mutants of Drosophila melanogaster.

Berger, Karen H; Kong, Eric C; Dubnau, Josh; Tully, Tim; Moore, Monica S; Heberlein, Ulrike.

Alcohol Clin Exp Res ; 32(5): 895-908, 2008 May.

Artigo em Inglês | MEDLINE | ID: mdl-18435628

17.

The Retrotransposon storm and the dangers of a Collyer's genome.

Dubnau, Josh.

Curr Opin Genet Dev ; 49: 95-105, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29705598

18.

The staufen/pumilio pathway is involved in Drosophila long-term memory.

Dubnau, Josh; Chiang, Ann-Shyn; Grady, Lori; Barditch, Jody; Gossweiler, Scott; McNeil, John; Smith, Patrick; Buldoc, Francois; Scott, Rod; Certa, Uli; Broger, Clemens; Tully, Tim.

Curr Biol ; 13(4): 286-96, 2003 Feb 18.

Artigo em Inglês | MEDLINE | ID: mdl-12593794

19.

radish encodes a phospholipase-A2 and defines a neural circuit involved in anesthesia-resistant memory.

Chiang, Ann-Shyn; Blum, Allison; Barditch, Jody; Chen, Ying-Hsiu; Chiu, Shu-Ling; Regulski, Michael; Armstrong, J Douglas; Tully, Tim; Dubnau, Josh.

Curr Biol ; 14(4): 263-72, 2004 Feb 17.

Artigo em Inglês | MEDLINE | ID: mdl-14972677

20.

A Leptin Analog Locally Produced in the Brain Acts via a Conserved Neural Circuit to Modulate Obesity-Linked Behaviors in Drosophila.

Beshel, Jennifer; Dubnau, Josh; Zhong, Yi.

Cell Metab ; 25(1): 208-217, 2017 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-28076762

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