Detalhe da pesquisa
1.
Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model.
Neurobiol Dis
; 196: 106523, 2024 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38705491
2.
Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models.
Hum Mol Genet
; 30(9): 771-788, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33693642
3.
Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.
PLoS Genet
; 11(3): e1005062, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25803843
4.
The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.
PLoS Genet
; 8(5): e1002724, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22693452
5.
Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage.
Neurobiol Dis
; 69: 65-75, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24801365
6.
DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.
Mol Genet Metab
; 110(3): 371-7, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23920041
7.
Ts66Yah, a mouse model of Down syndrome with improved construct and face validity.
Dis Model Mech
; 15(12)2022 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36374158
8.
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome.
Hum Mol Genet
; 18(24): 4756-69, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19783846
9.
Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.
Mamm Genome
; 22(11-12): 674-84, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21953411
10.
Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome.
Genes (Basel)
; 12(11)2021 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34828439
11.
Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABAA inverse agonist.
Br J Pharmacol
; 177(5): 1106-1118, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31652355
12.
A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment.
Sci Rep
; 10(1): 1143, 2020 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980673
13.
Author Correction: A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment.
Sci Rep
; 10(1): 10983, 2020 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32620926
14.
Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination.
Genetics
; 180(1): 51-9, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18757940
15.
Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organization.
PLoS Genet
; 2(7): e86, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16839184
16.
Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models.
Sci Rep
; 9(1): 3914, 2019 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30850713
17.
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
Nat Commun
; 10(1): 2129, 2019 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31086189
18.
Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.
Dis Model Mech
; 11(9)2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30115750
19.
DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome.
Front Behav Neurosci
; 10: 104, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27375444
20.
Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndrome.
PLoS One
; 10(2): e0115302, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25706610