Detalhe da pesquisa
1.
The landscape of BRCA1 and BRCA2 large rearrangements in an international cohort of over 20 000 ovarian tumors identified using next-generation sequencing.
Genes Chromosomes Cancer
; 62(10): 589-596, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37222498
2.
A phase Ib study of the highly selective MET-TKI savolitinib plus gefitinib in patients with EGFR-mutated, MET-amplified advanced non-small-cell lung cancer.
Invest New Drugs
; 39(2): 477-487, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33052556
3.
Three-dimensional reconstructions of Arp2/3 complex with bound nucleation promoting factors.
EMBO J
; 31(1): 236-47, 2012 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21934650
4.
Phase II study of the PI3K inhibitor pilaralisib (SAR245408; XL147) in patients with advanced or recurrent endometrial carcinoma.
Gynecol Oncol
; 136(2): 246-53, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25528496
5.
The RickA protein of Rickettsia conorii activates the Arp2/3 complex.
Nature
; 427(6973): 457-61, 2004 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-14749835
6.
Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions.
PLoS Biol
; 3(11): e383, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16262445
7.
Voxtalisib (XL765) in patients with relapsed or refractory non-Hodgkin lymphoma or chronic lymphocytic leukaemia: an open-label, phase 2 trial.
Lancet Haematol
; 5(4): e170-e180, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29550382
8.
Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844).
J Med Chem
; 59(15): 7066-74, 2016 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27355974
9.
Efficacy, safety, pharmacokinetics and pharmacodynamics of SAR245409 (voxtalisib, XL765), an orally administered phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor: a phase 1 expansion cohort in patients with relapsed or refractory lymphoma.
Leuk Lymphoma
; 56(6): 1763-70, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25300944
10.
Phase I Trial of the Pan-PI3K Inhibitor Pilaralisib (SAR245408/XL147) in Patients with Chronic Lymphocytic Leukemia (CLL) or Relapsed/Refractory Lymphoma.
Clin Cancer Res
; 21(14): 3160-9, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25840972
11.
Phase I dose-escalation study of the PI3K/mTOR inhibitor voxtalisib (SAR245409, XL765) plus temozolomide with or without radiotherapy in patients with high-grade glioma.
Neuro Oncol
; 17(9): 1275-83, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26019185
12.
The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer.
Mol Cancer Ther
; 14(2): 384-94, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25504634
13.
Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245409 (XL765), a novel, orally administered PI3K/mTOR inhibitor in patients with advanced solid tumors.
Clin Cancer Res
; 20(9): 2445-56, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24583798
14.
Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors.
Clin Cancer Res
; 20(1): 233-45, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24166903
15.
MET genetic abnormalities unreliable for patient selection for therapeutic intervention in oropharyngeal squamous cell carcinoma.
PLoS One
; 9(1): e84319, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24465403
16.
The structural basis of actin filament branching by the Arp2/3 complex.
J Cell Biol
; 180(5): 887-95, 2008 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18316411
17.
IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway.
J Biol Chem
; 282(1): 426-35, 2007 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17085436
18.
Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection.
Cell Microbiol
; 8(9): 1444-55, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16922863
19.
Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading.
J Biol Chem
; 281(22): 15352-60, 2006 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16574661
20.
Cortactin regulates cell migration through activation of N-WASP.
J Cell Sci
; 118(Pt 1): 79-87, 2005 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15585574