Bicuspid aortic valve endocarditis complicated by mitral valve aneurysm.

We describe a case of mitral valve aneurysm associated with concomitant aortic valve endocarditis. Aneurysms appear as a localized saccular bulge of the anterior leaflet into the left atrium and thus are often misdiagnosed as mitral valve prolapse, myxomatous mitral valve, or atrial myxoma. The presentation and management of mitral valve aneurysms are the subject of this case report.

Myopericarditis and myositis in a patient with COVID-19: a case report.

BACKGROUND: Concurrent myopericarditis and myositis can present in patients with pre-existing systemic inflammatory diseases. Here we present a case of myopericarditis and myositis associated with COVID-19, in the absence of respiratory symptoms. CASE SUMMARY: We present a middle-aged female with a history of hypertension and previous myopericarditis. The patient was admitted with symptoms of central chest pain, and ECG and echocardiographic features of myopericarditis. Her symptoms did not improve, and CT thorax suggested possible SARS-CoV-2 infection for which she tested positive, despite no respiratory symptoms. Whilst on the ward, she developed bilateral leg weakness and a raised creatine kinase (CK), and magnetic resonance imaging (MRI) of her thighs confirmed myositis. A cardiac MRI confirmed myopericarditis. She was treated with colchicine 500 µg twice daily, ibuprofen 400 mg three times day, and prednisolone 30 mg per day, and her symptoms and weakness improved. DISCUSSION: We describe the first reported case of concurrent myopericarditis, and myositis associated with COVID-19. Conventional therapy with colchicine, non-steroidal anti-inflammatory drugs, and glucocorticoids improved her symptoms, and reduced biochemical markers of myocardial and skeletal muscle inflammation.

British Society of Echocardiography Departmental Accreditation Standards 2019 with input from the Intensive Care Society.

This article sets out a summary of standards for departmental accreditation set by the British Society of Echocardiography (BSE) Departmental Accreditation Committee. Full accreditation standards are available at www.bsecho.org. The BSE were the first national organisation to establish a quality standards framework for departments that support the practice of individual echocardiographers. This is an updated version which recognises that, not only should all echocardiographers be individually accredited as competent to practice, but that departments also need to be well organised and have the facilities, equipment and processes to ensure the services they deliver are of an appropriate clinical standard. In combination with individual accreditation, departmental accreditation lays down standards to help ensure safe and effective patient care. These standards supersede the 2012 BSE Departmental Accreditation Standards. Standards are set to cover all potential areas of practice, including transthoracic (level 2) echocardiography, transoesophageal echocardiography, stress echocardiography, training, and emergency (level 1) echocardiography. The emergency echocardiography standard is a new addition to departmental accreditation and has been developed with input from the Intensive Care Society.

Effects of oral testosterone treatment on myocardial perfusion and vascular function in men with low plasma testosterone and coronary heart disease.

Intracoronary testosterone infusions induce coronary vasodilatation and increase coronary blood flow. Longer term testosterone supplementation favorably affected signs of myocardial ischemia in men with low plasma testosterone and coronary heart disease. However, the effects on myocardial perfusion are unknown. Effects of longer term testosterone treatment on myocardial perfusion and vascular function were investigated in men with CHD and low plasma testosterone. Twenty-two men (mean age 57 +/- 9 [SD] years) were randomly assigned to oral testosterone undecanoate (TU; 80 mg twice daily) or placebo in a crossover study design. After each 8-week period, subjects underwent at rest and adenosine-stress first-pass myocardial perfusion cardiovascular magnetic resonance, pulse-wave analysis, and endothelial function measurements using radial artery tonometry, blood sampling, anthropomorphic measurements, and quality-of-life assessment. Although no difference was found in global myocardial perfusion after TU compared with placebo, myocardium supplied by unobstructed coronary arteries showed increased perfusion (1.83 +/- 0.9 vs 1.52 +/- 0.65; p = 0.037). TU decreased basal radial and aortic augmentation indexes (p = 0.03 and p = 0.02, respectively), indicating decreased arterial stiffness, but there was no effect on endothelial function. TU significantly decreased high-density lipoprotein cholesterol and increased hip circumference, but had no effect on hemostatic factors, quality of life, and angina symptoms. In conclusion, oral TU had selective and modest enhancing effects on perfusion in myocardium supplied by unobstructed coronary arteries, in line with previous intracoronary findings. The TU-related decrease in basal arterial stiffness may partly explain previously shown effects of exogenous testosterone on signs of exercise-induced myocardial ischemia.

Acute streptococcal myopericarditis mimicking myocardial infarction.

A 25-year-old man who had recurrent sore throats presented with sharp central chest pain 5 hours after starting penicillin for tonsillitis. Electrocardiogram (ECG) revealed ST-segment elevation in leads I and aVL with reciprocal ST depression in lead III (Fig. 1). Troponin I was measured as 33 microg/L (normal range, b0.1 microg/L), and C-reactive protein (CRP) was 127 (normal range b10). Echocardiogram revealed a nondilated well-contracting left ventricle, and cardiac catheterization revealed normal coronary arteries. A diagnosis of acute myopericarditis was made, and he was treated with moxifloxacin. Throat swabs grew Lancefield group A Streptococcus. Over subsequent days, his symptoms and ECG changes resolved, and he was discharged on longterm prophylactic penicillin.

Long-term use of contraceptive depot medroxyprogesterone acetate in young women impairs arterial endothelial function assessed by cardiovascular magnetic resonance.

BACKGROUND: Depot medroxyprogesterone acetate (DMPA) inhibits proliferation of ovarian follicles, resulting in anovulation and a decrease in circulating estrogen; the latter action is potentially disadvantageous to cardiovascular health. We therefore investigated the vascular effects of long-term contraceptive DMPA in young women. METHODS AND RESULTS: Endothelium-dependent (hyperemia-induced flow-mediated dilatation [FMD]) and -independent (glyceryl trinitrate [GTN]) changes in brachial artery area were measured using cardiovascular magnetic resonance in 13 amenorrheic DMPA users (>1 year use; mean age 29+/-4 years) and in 10 controls (mean age 30+/-4 years, P=0.25) with regular menstrual cycles after validation of the technique. FMD and GTN responses were measured just before repeat MPA injection and 48 hours later (n=12) in DMPA users and during menstruation and midcycle (n=9) in controls. Serum-estradiol levels (S-estradiol) were measured at both visits. FMD was reduced in DMPA users compared with controls during menstruation (1.1% versus 8.0%, respectively P<0.01) without differences in GTN responses. S-estradiol levels in DMPA users were significantly lower than in controls during menstruation (58 versus 96 pmol/L, P<0.01). High levels of circulating MPA 48 hours after injection were not linked to an additional impairment in FMD (2.0% versus 3.1%, P=0.23). Estradiol levels were significantly correlated to FMD (r=0.43, P<0.01). CONCLUSIONS: Endothelium-dependent arterial function measured by cardiovascular magnetic resonance is impaired in chronic users of DMPA, and hypoestrogenism may be the mechanism of action. DMPA might adversely affect cardiovascular health, and in particular its use in women with cardiovascular disease should be additionally evaluated.

The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy.

OBJECTIVES: We sought to identify the histologic basis of myocardial late gadolinium enhancement cardiovascular magnetic resonance (CMR) in hypertrophic cardiomyopathy (HCM). BACKGROUND: The histologic basis of late gadolinium CMR in patients with HCM is unknown. METHODS: A 28-year-old male patient with HCM and heart failure underwent late gadolinium enhancement CMR and, 49 days later, heart transplantation. The explanted heart was examined histologically for the extent of collagen and disarray, and the results were compared with a previous in vivo CMR scan. RESULTS: Overall, 19% of the myocardium was collagen, but the amount per segment varied widely (SD +/- 19, range 0% to 71%). Both disarray and collagen were more likely to be found in the mesocardium than in the endo- or epicardium. There was a significant relationship between the extent of late gadolinium enhancement and collagen (r = 0.7, p < 0.0001) but not myocardial disarray (p = 0.58). Segments containing >15% collagen were more likely to have late gadolinium enhancement. Regional wall motion was inversely related to the extent of myocardial collagen and late gadolinium enhancement but not disarray (p = 0.0003, 0.04, and NS, respectively). CONCLUSIONS: In this patient with HCM and heart failure, regions of myocardial late gadolinium enhancement by CMR represented regions of increased myocardial collagen but not disarray.

The pathologic basis of Q-wave and non-Q-wave myocardial infarction: a cardiovascular magnetic resonance study.

OBJECTIVES: The purpose of this study was to determine the pathologic basis of Q-wave (QW) and non-Q-wave (NQW) myocardial infarction (MI). BACKGROUND: The QW/NQW distinction remains in wide clinical use but the meaning of the difference remains controversial. We hypothesized that measurement of total MI size and transmural extent by late gadolinium enhancement cardiovascular magnetic resonance (CMR) would identify the pathologic basis of QWs. METHODS: A total of 100 consecutive patients with documented previous MI had electrocardiogram and CMR on the same day. Patients with acute MI within seven days were excluded. Left ventricular function and the size and transmural extent of MI were quantified in the three major arterial territories and correlated with the presence of QW. RESULTS: Subendocardial MI showed QW in 28%. Transmural MI showed NQW in 29%. Of all MIs, 48% were at some point transmural, and 99% of these were at some point non-transmural. As MI size and number of transmural segments increased, the probability of QW increased (anterior: total size chi-square = 53, p < 0.0001, transmural extent chi-square = 36, p < 0.0001; inferior: total size chi-square = 16, p = 0.001, transmural extent chi-square = 10, p = 0.001). These findings did not hold for lateral MI. In a multivariate model, the transmural extent of MI was not an independent predictor of QW when total size of MI was removed. The QW/NQW classification was a good test for size of MI (area under receiver operating characteristic curve: anterior 0.90, inferior 0.77). CONCLUSIONS: The QW/NQW distinction is useful, but it is determined by the total size rather than transmural extent of underlying MI.

Segmentation of 4D cardiac MR images using a probabilistic atlas and the EM algorithm.

In this paper an automatic atlas-based segmentation algorithm for 4D cardiac MR images is proposed. The algorithm is based on the 4D extension of the expectation maximisation (EM) algorithm. The EM algorithm uses a 4D probabilistic cardiac atlas to estimate the initial model parameters and to integrate a priori information into the classification process. The probabilistic cardiac atlas has been constructed from the manual segmentations of 3D cardiac image sequences of 14 healthy volunteers. It provides space and time-varying probability maps for the left and right ventricles, the myocardium, and background structures such as the liver, stomach, lungs and skin. In addition to using the probabilistic cardiac atlas as a priori information, the segmentation algorithm incorporates spatial and temporal contextual information by using 4D Markov Random Fields. After the classification, the largest connected component of each structure is extracted using a global connectivity filter which improves the results significantly, especially for the myocardium. Validation against manual segmentations and computation of the correlation between manual and automatic segmentation on 249 3D volumes were calculated. We used the 'leave one out' test where the image set to be segmented was not used in the construction of its corresponding atlas. Results show that the procedure can successfully segment the left ventricle (LV) (r = 0.96), myocardium (r = 0.92) and right ventricle (r = 0.92). In addition, 4D images from 10 patients with hypertrophic cardiomyopathy were also manually and automatically segmented yielding a good correlation in the volumes of the LV (r = 0.93) and myocardium (0.94) when the atlas constructed with volunteers is blurred.

Myocardial late gadolinium enhancement in specific cardiomyopathies by cardiovascular magnetic resonance: a preliminary experience.

Late gadolinium enhancement cardiovascular magnetic resonance (CMR) can visualize myocardial interstitial abnormalities. The aim of this study was to assess whether regions of abnormal myocardium can also be visualized by late enhancement gadolinium CMR in the specific cardiomyopathies. A retrospective review of all referrals for gadolinium CMR with specific cardiomyopathy over 20 months. Nine patients with different specific cardiomyopathies were identified. Late enhancement was demonstrated in all patients, with a mean signal intensity of 390 +/- 220% compared with normal regions. The distribution pattern of late enhancement was unlike the subendocardial late enhancement related to coronary territories found in myocardial infarction. The affected areas included papillary muscles (sarcoid), the mid-myocardium (Anderson-Fabry disease, glycogen storage disease, myocarditis, Becker muscular dystrophy) and the global sub-endocardium (systemic sclerosis, Loeffler's endocarditis, amyloid, Churg-Strauss). Focal myocardial late gadolinium enhancement is found in the specific cardiomyopathies, and the pattern is distinct from that seen in infarction. Further systematic studies are warranted to assess whether the pattern and extent of late enhancement may aid diagnosis and prognostic assessment.

Optimization of the arterial input function for myocardial perfusion cardiovascular magnetic resonance.

PURPOSE: To determine how injection rate, cardiac function, and breathhold influence the arterial input function (AIF), in order to optimize the AIF in the clinical setting for quantitative myocardial perfusion cardiovascular magnetic resonance (CMR). MATERIALS AND METHODS: Gd (0.1 mmol/kg) bolus was injected at 3, 5, or 7 mL/second in 35 patients. In each cardiac cycle during the first-pass, a series of saturation recovery (SR) fast low-angle shot (FLASH) low resolution images with exponentially increasing SR delay times were acquired. Signal intensity (SI) time measurements were made from a region of interest (ROI) drawn in the ascending aorta (AA). The calculation of short T1s and thus peak Gd concentration [Gd] was performed by fitting the mean ROI SI against SR delay times. RESULTS: The mean peak [Gd] in the AA increased as injection rate increased from 3 mL/second (5.0 mM), to 5 mL/second (7.1 mM), to 7 mL/second (4 mM) (P < 0.0001). The peak [Gd] increased as the left ventricular stroke volume (LV SV) increased (P = 0.01). Breath holding was not found to influence peak [Gd]. CONCLUSION: In this study, we found that a high injection rate has advantages over lower injection speeds, although the duration of the AIF was apparently not significantly shortened by faster injection. The choice of expiration or inspiration as breathhold did not have a significant influence upon the AIF. Poor cardiac function was associated with a lower peak [Gd], indicating that first pass perfusion measurements in these patients will be suboptimal.

Interstudy reproducibility of quantitative perfusion cardiovascular magnetic resonance.

PURPOSE: To determine the interstudy reproducibility of quantitative first-pass perfusion cardiovascular magnetic resonance with comparison of 2 previously described analysis techniques. There is no published data on the interstudy reproducibility of perfusion cardiovascular magnetic resonance which can be used to determine the significance of longitudinal changes in myocardial perfusion after pharmacologic or therapeutic interventions with defined sample sizes. METHODS: Sixteen subjects (7 normal volunteers, 9 patients with coronary artery disease) had rest and adenosine stress perfusion cardiovascular magnetic resonance studies on two separate visits. A short axis slice was studied on each visit using a fast low-angle shot sequence. The global and regional myocardial perfusion reserve indices were calculated using 2 methods: model based constrained deconvolution with the Fermi function, and normalized upslopes. Reproducibility was defined as the standard deviation of the measurement differences, divided by the mean (coefficient of variation). RESULTS: The reproducibility of global myocardial perfusion reserve indices was 21% in normal volunteers, which was similar to that in patients with coronary artery disease (CAD) (23%, p = .88). The reproducibility of regional myocardial perfusion reserve indices was 28% (p = .45 vs. global analysis). The reproducibility of global MPRi was superior with Fermi deconvolution compared with normalized upslopes (21% vs. 41%, p = .02). CONCLUSION: At this stage of clinical development, the reproducibility of quantitative perfusion cardiovascular magnetic resonance is good, and superior using Fermi deconvolution in preference to upslope analysis.

Comparison of hybrid echo-planar imaging and FLASH myocardial perfusion cardiovascular MR imaging.

The purpose of this study was to compare fast single-shot gradient-echo (FLASH) and hybrid echo-planar imaging (EPI) magnetic resonance (MR) technologies regarding the relative contrast-to-noise ratio (CNR), spatiotemporal resolution, size of inducible perfusion defects, and presence of artifacts in patients with coronary artery disease (CAD). Fifteen patients with CAD underwent rest and adenosine stress gadolinium first-pass perfusion cardiovascular MR examinations with EPI and FLASH. The study was approved by the local ethics committee, and each subject gave written informed consent. The spatial resolution of the two sequences was made similar in nine patients, and the temporal resolution was made similar in six. The images were assessed for CNR, artifact, and size of inducible perfusion defects. The CNR was significantly higher with the EPI sequence, whether matched for spatial (32 vs 22 [46%], P < .001) or temporal (35 vs 23 [51%], P < .001) resolution. There was no significant difference in scoring for artifact or area and transmural extent of inducible perfusion defects with EPI and FLASH, whether matched for temporal or spatial resolution. Further work is warranted to determine the relative diagnostic accuracy of the two techniques.

False aortic aneurysm at site of previous coarctation repair: the role of cardiovascular magnetic resonance.

We describe a 37-year-old who presented with hemoptysis. Twenty-one years previously he had undergone Dacron patch aortoplasty for coarctation. Initial investigations failed to reveal the cause of the hemoptysis. Cardiovascular magnetic resonance (CMR) demonstrated an aneurysm at the site of the repair. He underwent successful repair of the aneurysm with a Gelseal interpositional graft.

Accurate assessment of the arterial input function during high-dose myocardial perfusion cardiovascular magnetic resonance.

PURPOSE: To develop a method for accurate measurement of the arterial input function (AIF) during high-dose, single-injection, quantitative T1-weighted myocardial perfusion cardiovascular magnetic resonance (CMR). MATERIALS AND METHODS: Fast injection of high-dose gadolinium with highly T1 sensitive myocardial perfusion imaging is normally incompatible with quantitative perfusion modeling because of distortion of the peak of the AIF caused by full recovery of the blood magnetization. We describe a new method that for each cardiac cycle uses a low-resolution short-axis (SA) image with a short saturation-recovery time immediately after the R-wave in order to measure the left ventricular (LV) blood pool signal, which is followed by a single SA high-resolution image with a long saturation-recovery time in order to measure the myocardial signal with high sensitivity. Fifteen subjects were studied. Using the new method, we compared the myocardial perfusion reserve (MPR) with that obtained from the dual-bolus technique (a low-dose bolus to measure the blood pool signal and a high-dose bolus to measure the myocardial signal). RESULTS: A small significant difference was found between MPRs calculated using the new method and the MPRs calculated using the dual-bolus method. CONCLUSION: This new method for measuring the AIF introduced no major error, while removing the practical difficulties of the dual-bolus approach. This suggests that quantification of the MPR can be achieved using the simple high-dose single-bolus technique, which could also image multiple myocardial slices.

Combined long- and short-axis myocardial perfusion cardiovascular magnetic resonance.

PURPOSE: To date, myocardial perfusion cardiovascular magnetic resonance (CMR) has been reported in single and multiple short-axis slices. Three short-axis planes can assess 16 segments of the standard 17-segment myocardial model, but this approach fails to assess the ventricular apex that requires at least one long-axis plane. We therefore evaluated the feasibility and benefit of combined long- and short-axis perfusion CMR to enable complete 17 segments coverage for comprehensive myocardial perfusion assessment. METHODS AND MATERIALS: Using a hybrid echo planar imaging (EPI) sequence, we performed rest and adenosine stress first-pass perfusion CMR studies with 3 short-axis (basal, mid, apical) planes, and additional long-axis planes in the same cardiac cycle in a broad range of cardiology patients. RESULTS: Perfusion CMR was performed in 53 consecutive patients using the combined short-long-axis imaging protocol. Twenty-nine of those studied had known or suspected coronary artery disease (CAD), 18 hypertrophic cardiomyopathy, and 6 suspected microvascular perfusion abnormalities. In 39 patients (70%), it was possible to acquire 5 slices at rest and stress including both the horizontal and vertical long axes. In 15 patients (27%), only one long-axis could be acquired, and in 2 patients (5%) only 3 slices (short axis) could be obtained. However, in none of the patients with known or suspected CAD was apical ischemia demonstrated by the long-axis views, despite apical ischemia having been demonstrated with recent SPECT studies in 8 of these patients. CONCLUSION: Rest-stress myocardial perfusion CMR is able to achieve complete segmental coverage of the myocardium using the combined short-long axis approach using an EPI sequence in 97% of a long series of consecutive cardiology patients, while maintaining excellent spatial resolution. However, the long-axis views were not found to be able to demonstrate inducible perfusion defects in the apex.

Gadolinium enhanced cardiovascular magnetic resonance in Anderson-Fabry disease. Evidence for a disease specific abnormality of the myocardial interstitium.

AIMS: Anderson-Fabry Disease (AFD), an X-linked disorder of sphingolipid metabolism, is a cause of idiopathic left ventricular hypertrophy but the mechanism of hypertrophy is poorly understood. Gadolinium enhanced cardiovascular magnetic resonance can detect focal myocardial fibrosis. We hypothesised that hyperenhancement would be present in AFD. METHODS AND RESULTS: Eighteen males (mean 43+/-14 years) and eight female heterozygotes (mean 48+/-12 years) with AFD underwent cine and late gadolinium cardiovascular magnetic resonance. Nine male (50%) had myocardial hyperenhancement ranging from 3.4% to 20.6% (mean 7.7+/-5.7%) of total myocardium; in males, percentage hyperenhancement related to LV mass index (r=0.78, P=0.0002) but not to ejection fraction or left ventricular volumes. Lesser hyperenhancement was also found in four (50%) heterozygous females (mean 4.6%). In 12 (92%) patients with abnormal gadolinium uptake, hyperenhancement occurred in the basal infero-lateral wall where, unlike myocardial infarction, it was not sub-endocardial. In two male patients with severe LVH (left ventricular hypertrophy) and systolic impairment there was additional hyperenhancement in other myocardial segments. CONCLUSIONS: These observations suggests that myocardial fibrosis occurs in AFD and may contribute to the hypertrophy and the natural history of the disease.