RESUMO
An efficient procedure for preparing enantiopure polycyclic ethers is reported. The protocol is based on the photo-oxidation/conjugate addition sequence over a chiral functionalized furan, which was prepared from commercially available tri-O-acetyl-D-glucal. The Michael addition step afforded two products with the same absolute configuration from a mixture of diastereomers.
Assuntos
Éteres/química , Compostos Policíclicos/química , Compostos Policíclicos/síntese química , Produtos Biológicos/química , Técnicas de Química Sintética , Piranos/química , Estereoisomerismo , Toxinas Biológicas/químicaRESUMO
Hepatitis B is endemic in Senegal. According to many data, the prevalence of this infection in adult population is up 85%. Young children are victims of the intensive circulation of this virus. Indeed, the risk of becoming chronic carrier which can further lead to Hepatocellular Carcinoma, is related to the age at which the infection had been contracted. In this study, we investigated the prevalence of HBV markers in children less than 5 years living in two regions of Senegal: Dakar and Thies. Using specific Elisa methods, HBV markers were determined in 2962 sera of newborns and children: AgHBs, antiHBc, antiHBs for all children; AgHBe and IgM antiHBc for AgHBs carriers. HBV markers were detected in 59.38% of sera; in 39.26% of the samples only one marker was detected: AgHBs (3.18%), antiHBc (36.08%), antiHBs (0.49%). In 20.12% of samples, markers were associated. So, the global prevalence of the infection is 59.38% with the predominance of chronic forms compared to acute one. The rate of chronic carriage is independent of the sex but is influenced by age and geographic area. The post- infection immunization rate is 7.11%. In Senegal Hepatitis B is contracted at the early childhood. The high prevalence of this infection in children under five years emphasize the need for a spread vaccination in this age bracket, since we well know that the risk for them to become chronic carriers is high.
Assuntos
Anticorpos Antivirais/análise , Vírus da Hepatite B/imunologia , Vírus da Hepatite B/patogenicidade , Hepatite B/epidemiologia , Idade de Início , Biomarcadores/análise , Pré-Escolar , Ensaio de Imunoadsorção Enzimática , Feminino , Hepatite B/virologia , Vacinas contra Hepatite B/uso terapêutico , Humanos , Lactente , Recém-Nascido , Masculino , Prevalência , Fatores de Risco , SenegalRESUMO
Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The affinities of these compounds for DA (D2A, D3) and 5HT1A receptors were evaluated for their ability to displace [3H]-raclopride and [3H]-8-OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5-HT1A > D2 > D3.