Detalhe da pesquisa
1.
Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H3 and dopamine D3 receptors.
Bioorg Med Chem
; 78: 117132, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36542960
2.
Piperazine amides with desirable solubility, physicochemical and drug-like properties: Synthesis and evaluation of the anti-Trypanosoma cruzi activity.
Saudi Pharm J
; 31(7): 1265-1273, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37287509
3.
Histamine research advancements in the second year of the COVID-19 pandemic: report of the European Histamine Research Society (EHRS).
Inflamm Res
; 71(7-8): 995-998, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35648157
4.
Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H3 and H4 receptors.
Bioorg Med Chem
; 30: 115924, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33333448
5.
The Novel H4R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma.
Cell Physiol Biochem
; 54(6): 1163-1176, 2020 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33216475
6.
Coumaric acid derivatives as tyrosinase inhibitors: Efficacy studies through in silico, in vitro and ex vivo approaches.
Bioorg Chem
; 103: 104108, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32750608
7.
Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives.
Bioorg Chem
; 89: 102996, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31132603
8.
Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
Bioorg Med Chem Lett
; 26(4): 1180-3, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26821820
9.
The histamine H4 receptor antagonist 1-[(5-chloro-2,3-dihydro-1-benzofuran-2-yl)methyl]-4-methyl-piperazine(LINS01007) prevents the development of DSS-induced colitis in mice.
Int Immunopharmacol
; 133: 112128, 2024 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38652966
10.
Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in Trypanosoma cruzi.
Life (Basel)
; 13(3)2023 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36983820
11.
Investigation of Structure-Activity Relationships for Benzoyl and Cinnamoyl Piperazine/Piperidine Amides as Tyrosinase Inhibitors.
ACS Omega
; 8(46): 44265-44275, 2023 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38027351
12.
Lethal action of Licarin A derivatives in Leishmania (L.) infantum: Imbalance of calcium and bioenergetic metabolism.
Biochimie
; 208: 141-150, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36586562
13.
Toward anthelmintic drug candidates for toxocariasis: Challenges and recent developments.
Eur J Med Chem
; 251: 115268, 2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36921525
14.
Esterification of p-Coumaric Acid Improves the Control over Melanoma Cell Growth.
Biomedicines
; 11(1)2023 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36672704
15.
Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi.
Eur J Pharm Sci
; 171: 106114, 2022 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34986415
16.
Bioisosteric modification on benzylidene-carbonyl compounds improved the drug-likeness and maintained the antifungal activity against Sporothrix brasiliensis.
Chem Biol Drug Des
; 99(3): 391-397, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34873847
17.
Neurotoxicity Assessment of 1-[(2,3-Dihydro-1-Benzofuran-2-yl)Methyl]Piperazine (LINS01 Series) Derivatives and their Protective Effect on Cocaine-Induced Neurotoxicity Model in SH-SY5Y Cell Culture.
Neurotox Res
; 40(6): 1653-1663, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36342586
18.
Evaluation of the histamine H3 receptor antagonists from LINS01 series as cholinesterases inhibitors: Enzymatic and modeling studies.
Chem Biol Drug Des
; 100(5): 722-729, 2022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-36050829
19.
Histamine H3 receptor and cholinesterases as synergistic targets for cognitive decline: Strategies to the rational design of multitarget ligands.
Chem Biol Drug Des
; 98(2): 212-225, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991182
20.
Metabolite profile of Nectandra oppositifolia Nees & Mart. and assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses.
PLoS One
; 16(2): e0247334, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33630860